FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387576304> ?p ?o ?g. }

• W4387576304 endingPage "7037" @default.
• W4387576304 startingPage "7037" @default.
• W4387576304 abstract "Coffee became a beverage that was in demand in the world and consequently produced millions of tons of coffee byproducts namely coffee silverskin (CS). Unutilized CS will be waste and cause environmental pollution such as greenhouse gas emissions, landfill waste, and groundwater contamination. This is a research concern at this time, although many studies have been conducted to find newer applications of CS, exploration of its benefits in the health sector is still limited. Therefore, exploring the benefits of CS to prevent or delay aging will be very interesting to develop in functional food industry technology. Therefore, this study aims to report profiling metabolites or phytochemicals, biological activities in terms of antioxidant activity, and potential anti-aging of CS via molecular docking simulation and in vitro modulation of the mTOR/AMPK/SIRT1 pathway. Something new has been obtained from this work, the profile of phytocompounds, and biological activities both in molecular docking simulation and in vitro studies. Some of the compounds observed in Robusta CS extract (rCSE) such as Epicatechin, Kaempferol, and Quercitrin, and Arabica CS extract (aCSE) such as (+)-Catechin dan Naringin have promising potential as inhibitors of iNOS, mTOR, and HIF-1α via molecular docking simulation. Interestingly, the in vitro biological activity assay of antioxidant and anti-aging activity, rCSE showed the same promising potential as the results of a molecular docking simulation. More interestingly, AMPK/SIRT1/mTOR expressions are well modulated by rCSE compared to aCSE significantly (p < 0.05). This makes the rCSE have promising biological activity as a candidate for functional food development and/or treatment agent in combating free radicals that cause the aging process. In vivo studies and human trials are certainly needed to see the further efficacy of the rCSE in the future." @default.
• W4387576304 created "2023-10-13" @default.
• W4387576304 creator A5000552265 @default.
• W4387576304 creator A5008360631 @default.
• W4387576304 creator A5008884512 @default.
• W4387576304 creator A5014225429 @default.
• W4387576304 creator A5018977246 @default.
• W4387576304 creator A5021238440 @default.
• W4387576304 creator A5034601041 @default.
• W4387576304 creator A5048358667 @default.
• W4387576304 creator A5052962972 @default.
• W4387576304 creator A5055802547 @default.
• W4387576304 creator A5068542027 @default.
• W4387576304 creator A5071428520 @default.
• W4387576304 creator A5092228227 @default.
• W4387576304 date "2023-10-11" @default.
• W4387576304 modified "2023-10-14" @default.
• W4387576304 title "Coffee Silverskin Phytocompounds as a Novel Anti-Aging Functional Food: A Pharmacoinformatic Approach Combined with In Vitro Study" @default.
• W4387576304 cites W1971155457 @default.
• W4387576304 cites W1986161429 @default.
• W4387576304 cites W1989395374 @default.
• W4387576304 cites W2000821991 @default.
• W4387576304 cites W2039977572 @default.
• W4387576304 cites W2090329312 @default.
• W4387576304 cites W2419338819 @default.
• W4387576304 cites W2425174850 @default.
• W4387576304 cites W2528674304 @default.
• W4387576304 cites W2776443768 @default.
• W4387576304 cites W2883044784 @default.
• W4387576304 cites W2895344835 @default.
• W4387576304 cites W2900923558 @default.
• W4387576304 cites W2921646079 @default.
• W4387576304 cites W2947958232 @default.
• W4387576304 cites W2955656412 @default.
• W4387576304 cites W2986920744 @default.
• W4387576304 cites W3000224932 @default.
• W4387576304 cites W3006710361 @default.
• W4387576304 cites W3006891752 @default.
• W4387576304 cites W3047265775 @default.
• W4387576304 cites W3080403357 @default.
• W4387576304 cites W3119900190 @default.
• W4387576304 cites W3129711372 @default.
• W4387576304 cites W3163021674 @default.
• W4387576304 cites W3184094042 @default.
• W4387576304 cites W3189312452 @default.
• W4387576304 cites W3197503074 @default.
• W4387576304 cites W3213583402 @default.
• W4387576304 cites W3215749201 @default.
• W4387576304 cites W3216168417 @default.
• W4387576304 cites W4210584944 @default.
• W4387576304 cites W4232778325 @default.
• W4387576304 cites W4285389247 @default.
• W4387576304 cites W4286447743 @default.
• W4387576304 cites W4292411308 @default.
• W4387576304 cites W4297876389 @default.
• W4387576304 cites W4307715807 @default.
• W4387576304 cites W4321380556 @default.
• W4387576304 cites W4324131435 @default.
• W4387576304 cites W4360604417 @default.
• W4387576304 cites W4362666262 @default.
• W4387576304 cites W4366813978 @default.
• W4387576304 cites W4366818785 @default.
• W4387576304 doi "https://doi.org/10.3390/molecules28207037" @default.
• W4387576304 hasPublicationYear "2023" @default.
• W4387576304 type Work @default.
• W4387576304 citedByCount "0" @default.
• W4387576304 crossrefType "journal-article" @default.
• W4387576304 hasAuthorship W4387576304A5000552265 @default.
• W4387576304 hasAuthorship W4387576304A5008360631 @default.
• W4387576304 hasAuthorship W4387576304A5008884512 @default.
• W4387576304 hasAuthorship W4387576304A5014225429 @default.
• W4387576304 hasAuthorship W4387576304A5018977246 @default.
• W4387576304 hasAuthorship W4387576304A5021238440 @default.
• W4387576304 hasAuthorship W4387576304A5034601041 @default.
• W4387576304 hasAuthorship W4387576304A5048358667 @default.
• W4387576304 hasAuthorship W4387576304A5052962972 @default.
• W4387576304 hasAuthorship W4387576304A5055802547 @default.
• W4387576304 hasAuthorship W4387576304A5068542027 @default.
• W4387576304 hasAuthorship W4387576304A5071428520 @default.
• W4387576304 hasAuthorship W4387576304A5092228227 @default.
• W4387576304 hasBestOaLocation W43875763041 @default.
• W4387576304 hasConcept C150903083 @default.
• W4387576304 hasConcept C185592680 @default.
• W4387576304 hasConcept C2778004101 @default.
• W4387576304 hasConcept C2779431889 @default.
• W4387576304 hasConcept C55493867 @default.
• W4387576304 hasConcept C70899900 @default.
• W4387576304 hasConcept C86803240 @default.
• W4387576304 hasConcept C98274493 @default.
• W4387576304 hasConceptScore W4387576304C150903083 @default.
• W4387576304 hasConceptScore W4387576304C185592680 @default.
• W4387576304 hasConceptScore W4387576304C2778004101 @default.
• W4387576304 hasConceptScore W4387576304C2779431889 @default.
• W4387576304 hasConceptScore W4387576304C55493867 @default.
• W4387576304 hasConceptScore W4387576304C70899900 @default.
• W4387576304 hasConceptScore W4387576304C86803240 @default.
• W4387576304 hasConceptScore W4387576304C98274493 @default.
• W4387576304 hasIssue "20" @default.

• next