Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387580351> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W4387580351 abstract "Abstract Background: This study was to evaluate the effectiveness and safety of the preoperative regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer (LACC). Methods: Trans-arterial programmed cell death receptor 1 (PD-1) monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin chemotherapy was adopted as neoadjuvant therapy in six patients with primary LACC (stage IIB-IVA) who were willing to undergo surgical resection, and treatment effectiveness was evaluated according to the RECIST 1.1 criteria. If the local tumor was regressive and assessed as operable, surgery was performed, and postoperative adjuvant therapy was selected based on the histopathological findings. Results: One patient was discontinued the neoadjuvant therapy from the study due to an allergic reaction during the 2 nd course and underwent surgical resection directly. Five patients achieved partial response after neoadjuvant therapy with an objective response rate of 100% and a surgical conversion rate of 100%. All patients had R0 resection. Serious adverse events did not occur during neoadjuvant therapy. The six patients were followed up for 15-30 months (median, 23.5 months) and none of them relapsed. Conclusions: Trans-arterial PD-1 monoclonal antibody infusion combined with intravenous paclitaxel-cisplatin as neoadjuvant therapy in patients with LACC showed a higher objective response rate, surgical conversion rate, and safety with satisfactory near-term outcomes. Further investigation is required to substantiate the outcome of regional trans-arterial infusion immunotherapy combined with intravenous chemotherapy as an alternative treatment modality for LACC." @default.
- W4387580351 created "2023-10-13" @default.
- W4387580351 creator A5003807314 @default.
- W4387580351 creator A5006685364 @default.
- W4387580351 creator A5014307249 @default.
- W4387580351 creator A5026930111 @default.
- W4387580351 creator A5035640195 @default.
- W4387580351 creator A5040472854 @default.
- W4387580351 creator A5046694245 @default.
- W4387580351 creator A5051735034 @default.
- W4387580351 creator A5088208045 @default.
- W4387580351 creator A5089823903 @default.
- W4387580351 date "2023-10-12" @default.
- W4387580351 modified "2023-10-14" @default.
- W4387580351 title "Regional trans-arterial immunotherapy combined with intravenous chemotherapy in patients with locally advanced cervical cancer as preoperative neoadjuvant therapy: A case series study " @default.
- W4387580351 cites W1977923809 @default.
- W4387580351 cites W2021292249 @default.
- W4387580351 cites W2066671159 @default.
- W4387580351 cites W2126768246 @default.
- W4387580351 cites W2324392028 @default.
- W4387580351 cites W2786727643 @default.
- W4387580351 cites W2899050317 @default.
- W4387580351 cites W2901272595 @default.
- W4387580351 cites W2925815206 @default.
- W4387580351 cites W2952695966 @default.
- W4387580351 cites W2971323891 @default.
- W4387580351 cites W2982617740 @default.
- W4387580351 cites W3031687549 @default.
- W4387580351 cites W3200231835 @default.
- W4387580351 cites W4255356077 @default.
- W4387580351 cites W2105507245 @default.
- W4387580351 doi "https://doi.org/10.21203/rs.3.rs-3306192/v1" @default.
- W4387580351 hasPublicationYear "2023" @default.
- W4387580351 type Work @default.
- W4387580351 citedByCount "0" @default.
- W4387580351 crossrefType "posted-content" @default.
- W4387580351 hasAuthorship W4387580351A5003807314 @default.
- W4387580351 hasAuthorship W4387580351A5006685364 @default.
- W4387580351 hasAuthorship W4387580351A5014307249 @default.
- W4387580351 hasAuthorship W4387580351A5026930111 @default.
- W4387580351 hasAuthorship W4387580351A5035640195 @default.
- W4387580351 hasAuthorship W4387580351A5040472854 @default.
- W4387580351 hasAuthorship W4387580351A5046694245 @default.
- W4387580351 hasAuthorship W4387580351A5051735034 @default.
- W4387580351 hasAuthorship W4387580351A5088208045 @default.
- W4387580351 hasAuthorship W4387580351A5089823903 @default.
- W4387580351 hasBestOaLocation W43875803511 @default.
- W4387580351 hasConcept C121608353 @default.
- W4387580351 hasConcept C126322002 @default.
- W4387580351 hasConcept C141071460 @default.
- W4387580351 hasConcept C143998085 @default.
- W4387580351 hasConcept C146357865 @default.
- W4387580351 hasConcept C151730666 @default.
- W4387580351 hasConcept C197934379 @default.
- W4387580351 hasConcept C2776694085 @default.
- W4387580351 hasConcept C2777701055 @default.
- W4387580351 hasConcept C2778220009 @default.
- W4387580351 hasConcept C2778239845 @default.
- W4387580351 hasConcept C2778292576 @default.
- W4387580351 hasConcept C530470458 @default.
- W4387580351 hasConcept C71924100 @default.
- W4387580351 hasConcept C86803240 @default.
- W4387580351 hasConceptScore W4387580351C121608353 @default.
- W4387580351 hasConceptScore W4387580351C126322002 @default.
- W4387580351 hasConceptScore W4387580351C141071460 @default.
- W4387580351 hasConceptScore W4387580351C143998085 @default.
- W4387580351 hasConceptScore W4387580351C146357865 @default.
- W4387580351 hasConceptScore W4387580351C151730666 @default.
- W4387580351 hasConceptScore W4387580351C197934379 @default.
- W4387580351 hasConceptScore W4387580351C2776694085 @default.
- W4387580351 hasConceptScore W4387580351C2777701055 @default.
- W4387580351 hasConceptScore W4387580351C2778220009 @default.
- W4387580351 hasConceptScore W4387580351C2778239845 @default.
- W4387580351 hasConceptScore W4387580351C2778292576 @default.
- W4387580351 hasConceptScore W4387580351C530470458 @default.
- W4387580351 hasConceptScore W4387580351C71924100 @default.
- W4387580351 hasConceptScore W4387580351C86803240 @default.
- W4387580351 hasLocation W43875803511 @default.
- W4387580351 hasOpenAccess W4387580351 @default.
- W4387580351 hasPrimaryLocation W43875803511 @default.
- W4387580351 hasRelatedWork W1971929983 @default.
- W4387580351 hasRelatedWork W2021865845 @default.
- W4387580351 hasRelatedWork W2066496973 @default.
- W4387580351 hasRelatedWork W2091461259 @default.
- W4387580351 hasRelatedWork W2100875939 @default.
- W4387580351 hasRelatedWork W2149068418 @default.
- W4387580351 hasRelatedWork W2406596433 @default.
- W4387580351 hasRelatedWork W2406608798 @default.
- W4387580351 hasRelatedWork W2460036924 @default.
- W4387580351 hasRelatedWork W3120025342 @default.
- W4387580351 isParatext "false" @default.
- W4387580351 isRetracted "false" @default.
- W4387580351 workType "article" @default.