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• W4387581382 abstract "Aberrantly glycosylated mucin 1 is a critical prognostic biomarker in breast epithelial cancers. Hypoglycosylated mucin 1 coats the surface of the cancer cells, where O-glycans are predominantly linked via an N-acetylgalactosamine moiety (GalNAc). Cancer cell-derived extracellular vesicles (EVs) carry biomarkers from parent cancer cells to the recipient cells and, therefore, could potentially be leveraged for diagnostics and noninvasive disease monitoring. We devised a label-free approach for identifying glycoprotein mucin 1 overexpression on breast cancer EVs. While exploring a plethora of biochemical (enzyme-linked immunosorbent assay, flow cytometry, and SDS-PAGE) and label-free biophysical techniques (circular dichroism and infrared spectroscopy (IR)) along with multivariate analysis, we discovered that mucin 1 is significantly overexpressed in breast cancer EVs and aberrant glycosylation in mucin 1 could be critically addressed using IR and multivariate analysis targeting the GalNAc sugar. This approach emerges as a convenient and comprehensive method of distinguishing cancer EVs from normal samples and holds potential for nonintrusive breast cancer liquid biopsy screening." @default.
• W4387581382 created "2023-10-13" @default.
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• W4387581382 date "2023-10-12" @default.
• W4387581382 modified "2023-10-14" @default.
• W4387581382 title "Probing Aberrantly Glycosylated Mucin 1 in Breast Cancer Extracellular Vesicles" @default.
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• W4387581382 doi "https://doi.org/10.1021/acsabm.3c00651" @default.
• W4387581382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37824707" @default.
• W4387581382 hasPublicationYear "2023" @default.
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