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- W4387590007 abstract "This month's Oncology Scan focuses on 3 recent studies that examined internal mammary node (IMN) irradiation (IMNI) and offers our perspective on their applicability to clinical practice. The IMNI debate continues due to a couple of key issues. First, until recently, there was only 1 negative randomized clinical trial of IMNI versus no IMNI demonstrating no improvement in 10-year overall survival (OS). 1 Hennequin C Bossard N Servagi-Vernat S et al. Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy. Int J Radiat Oncol Biol Phys. 2013; 86: 860-866 Abstract Full Text Full Text PDF PubMed Scopus (199) Google Scholar This study began over 30 years ago, and the final report was issued a decade ago, but this negative trial has allowed the IMNI debate to persist. Second, isolated IMN recurrences as a first recurrence are rare events, which may lead some to believe that irradiation of this regional lymph node group may not be necessary in most cases. Last, there is concern that IMNI results in increased lung and cardiac dose, particularly for left-sided tumors, which may therefore lead to an increase in late toxicity that offsets any potential benefit of IMNI." @default.
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- W4387590007 date "2023-11-01" @default.
- W4387590007 modified "2023-10-16" @default.
- W4387590007 title "The Internal Mammary Node Irradiation Debate in Node-Positive Breast Cancer: Case Closed" @default.
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- W4387590007 doi "https://doi.org/10.1016/j.ijrobp.2023.07.021" @default.
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