Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387599320> ?p ?o ?g. }
- W4387599320 abstract "Perineural invasion (PNI) has emerged as a key pathological feature and be considered as a poor prognostic factor in cervical cancer. However, the underlying molecular mechanisms are largely unknown. Here, PNI status of 269 cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) samples were quantified by using whole-slide diagnostic images obtained from The Cancer Genome Atlas. Integrated analyses revealed that PNI was an indicative marker of poorer disease-free survival for CESC patients. Among the differentially expressed genes, ADCYAP1 were identified. Clinical specimens supported that high expression of PACAP (encoded by ADCYAP1) contributed to PNI in CESC. Mechanistically, PACAP, secreted from cervical cancer cells, reversed myelin differentiation of Schwann cells (SCs). Then, dedifferentiated SCs promoted PNI by producing chemokine FGF17 and by degrading extracellular matrix through secretion of Cathepsin S and MMP-12. In conclusion, this study identified PACAP was associated with PNI in cervical cancer and suggested that tumour-derived PACAP reversed myelin differentiation of SCs to aid PNI." @default.
- W4387599320 created "2023-10-14" @default.
- W4387599320 creator A5000875888 @default.
- W4387599320 creator A5012288369 @default.
- W4387599320 creator A5023690905 @default.
- W4387599320 creator A5050913370 @default.
- W4387599320 creator A5053367728 @default.
- W4387599320 creator A5058913315 @default.
- W4387599320 creator A5087648864 @default.
- W4387599320 creator A5087880097 @default.
- W4387599320 date "2023-10-13" @default.
- W4387599320 modified "2023-10-14" @default.
- W4387599320 title "Dedifferentiated Schwann cells promote perineural invasion mediated by the <scp>PACAP</scp> paracrine signalling in cervical cancer" @default.
- W4387599320 cites W1519634071 @default.
- W4387599320 cites W1532654778 @default.
- W4387599320 cites W1936545810 @default.
- W4387599320 cites W1975483277 @default.
- W4387599320 cites W1981423842 @default.
- W4387599320 cites W1988476050 @default.
- W4387599320 cites W1990095749 @default.
- W4387599320 cites W1999286614 @default.
- W4387599320 cites W2014087908 @default.
- W4387599320 cites W2014110211 @default.
- W4387599320 cites W2049711605 @default.
- W4387599320 cites W2049848084 @default.
- W4387599320 cites W2080357358 @default.
- W4387599320 cites W2085424855 @default.
- W4387599320 cites W2091611675 @default.
- W4387599320 cites W2102232105 @default.
- W4387599320 cites W2113774043 @default.
- W4387599320 cites W2120421863 @default.
- W4387599320 cites W2127338217 @default.
- W4387599320 cites W2128902280 @default.
- W4387599320 cites W2165973972 @default.
- W4387599320 cites W2176714462 @default.
- W4387599320 cites W2218151226 @default.
- W4387599320 cites W2306715392 @default.
- W4387599320 cites W2414050843 @default.
- W4387599320 cites W2717517667 @default.
- W4387599320 cites W2743621029 @default.
- W4387599320 cites W2757127337 @default.
- W4387599320 cites W2889212234 @default.
- W4387599320 cites W2896045928 @default.
- W4387599320 cites W2906657810 @default.
- W4387599320 cites W2935728070 @default.
- W4387599320 cites W2944079325 @default.
- W4387599320 cites W2945293993 @default.
- W4387599320 cites W2949273159 @default.
- W4387599320 cites W2991637326 @default.
- W4387599320 cites W3003716634 @default.
- W4387599320 cites W3015406562 @default.
- W4387599320 cites W3030793585 @default.
- W4387599320 cites W3049395816 @default.
- W4387599320 cites W3096121411 @default.
- W4387599320 cites W3120036594 @default.
- W4387599320 cites W3214876529 @default.
- W4387599320 cites W4211115458 @default.
- W4387599320 cites W4224251078 @default.
- W4387599320 cites W4281254956 @default.
- W4387599320 doi "https://doi.org/10.1111/jcmm.17897" @default.
- W4387599320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37830980" @default.
- W4387599320 hasPublicationYear "2023" @default.
- W4387599320 type Work @default.
- W4387599320 citedByCount "0" @default.
- W4387599320 crossrefType "journal-article" @default.
- W4387599320 hasAuthorship W4387599320A5000875888 @default.
- W4387599320 hasAuthorship W4387599320A5012288369 @default.
- W4387599320 hasAuthorship W4387599320A5023690905 @default.
- W4387599320 hasAuthorship W4387599320A5050913370 @default.
- W4387599320 hasAuthorship W4387599320A5053367728 @default.
- W4387599320 hasAuthorship W4387599320A5058913315 @default.
- W4387599320 hasAuthorship W4387599320A5087648864 @default.
- W4387599320 hasAuthorship W4387599320A5087880097 @default.
- W4387599320 hasBestOaLocation W43875993201 @default.
- W4387599320 hasConcept C121608353 @default.
- W4387599320 hasConcept C126322002 @default.
- W4387599320 hasConcept C13373296 @default.
- W4387599320 hasConcept C142724271 @default.
- W4387599320 hasConcept C170493617 @default.
- W4387599320 hasConcept C2776914184 @default.
- W4387599320 hasConcept C2777154038 @default.
- W4387599320 hasConcept C2778220009 @default.
- W4387599320 hasConcept C2781182431 @default.
- W4387599320 hasConcept C502942594 @default.
- W4387599320 hasConcept C71924100 @default.
- W4387599320 hasConcept C7876069 @default.
- W4387599320 hasConcept C86803240 @default.
- W4387599320 hasConceptScore W4387599320C121608353 @default.
- W4387599320 hasConceptScore W4387599320C126322002 @default.
- W4387599320 hasConceptScore W4387599320C13373296 @default.
- W4387599320 hasConceptScore W4387599320C142724271 @default.
- W4387599320 hasConceptScore W4387599320C170493617 @default.
- W4387599320 hasConceptScore W4387599320C2776914184 @default.
- W4387599320 hasConceptScore W4387599320C2777154038 @default.
- W4387599320 hasConceptScore W4387599320C2778220009 @default.
- W4387599320 hasConceptScore W4387599320C2781182431 @default.
- W4387599320 hasConceptScore W4387599320C502942594 @default.
- W4387599320 hasConceptScore W4387599320C71924100 @default.
- W4387599320 hasConceptScore W4387599320C7876069 @default.
- W4387599320 hasConceptScore W4387599320C86803240 @default.