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- W4387599978 abstract "Helicobacter pylori, invades the gastric mucosa and is one of the causative agents of stomach cancer and peptic ulcers. Origanum vulgare, is a flavouring herb used worldwide. But little is known about the effects of extracts prepared by maceration in cold PBS. This study was aimed at determining the superoxide dismutase (SOD)- and peroxidase (Px)-like antioxidant activities as well as the immunomodulatory activity (anti-inflammatory/pro-inflammatory) of an aqueous extract of O. vulgare by evaluating the production of nitric oxide (NO) in macrophages stimulated with H. pylori derivatives. The cold extract presented SOD-like and Px-like activities with effective concentration 50 (EC50) values of Px = 489.7 ± 48 µg/ml and SOD= 384.7 ± 30 µg/ml. The extract was also capable of modulating the production of NO in macrophages stimulated by H. pylori derivatives by exerting a pro-inflammatory activity at high concentrations and an anti-inflammatory activity at low concentrations." @default.
- W4387599978 created "2023-10-14" @default.
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- W4387599978 date "2023-10-13" @default.
- W4387599978 modified "2023-10-18" @default.
- W4387599978 title "<i>Origanum vulgare</i> : peroxidase-, superoxide dismutase- and immunomodulatory activities on macrophages activated with <i>Helicobacter pylori</i> derivatives" @default.
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- W4387599978 doi "https://doi.org/10.1080/14786419.2023.2269593" @default.
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