Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387600647> ?p ?o ?g. }
- W4387600647 endingPage "112309" @default.
- W4387600647 startingPage "112309" @default.
- W4387600647 abstract "Neuronal hyperactivity is a key abnormality in early stage Alzheimer's disease (AD). Medial entorhinal cortex (mEC) plays a vital role in memory function and is affected early in AD. Growing evidence indicates benefits of regular exercise on memory and cognitive function in humans with AD, although, the underlying mechanisms are not clear. Therefore, this study was designed to test the effects of 16 weeks treadmill exercise on spatial learning memory and the underlying cellular mechanisms in 6-month-old 3xTg-AD mice. Whole-cell patch clamp was used to examine neuronal intrinsic excitability, spontaneous excitatory postsynaptic currents (sEPSCs) and spontaneous inhibitory postsynaptic currents (sIPSCs) of mEC layer II/III pyramidal neurons in the following groups: wild type (WT + sham), 3xTg-AD (AD+sham), WT receiving exercise (WT + Ex), and AD receiving exercise (AD+Ex). We found that at a behavioral level, treadmill exercise decreased working memory errors in radial arm maze (RAM) test in 6-month-old AD mice. At a cellular level, we found that treadmill exercise prevented the abnormal increase in mEC pyramidal neuron input resistance and action potential firing in 6-month-old 3xTg-AD mice compared with WT + sham and AD+Ex mice; further, sEPSC amplitude and frequency were normal in AD+Ex but overactive in AD+sham; additionally, GABAergic inhibition was normal in AD+Ex mice but reduced in AD+sham. In conclusion, our results indicate that treadmill exercise improves spatial learning memory and prevents network hyperexcitability in mEC by reducing pyramidal neuronal intrinsic excitability and normalizing excitatory and inhibitory synaptic transmission in 3xTg-AD mice." @default.
- W4387600647 created "2023-10-14" @default.
- W4387600647 creator A5023393797 @default.
- W4387600647 creator A5031067860 @default.
- W4387600647 creator A5038499684 @default.
- W4387600647 creator A5067649805 @default.
- W4387600647 creator A5078573475 @default.
- W4387600647 creator A5083885486 @default.
- W4387600647 date "2023-10-01" @default.
- W4387600647 modified "2023-10-15" @default.
- W4387600647 title "Treadmill exercise prevents the hyperexcitability of pyramidal neurons in medial entorhinal cortex in the 3xTg-AD mouse model of Alzheimer's disease" @default.
- W4387600647 cites W1663655962 @default.
- W4387600647 cites W1742979798 @default.
- W4387600647 cites W1927567505 @default.
- W4387600647 cites W1950985564 @default.
- W4387600647 cites W1966100017 @default.
- W4387600647 cites W1967464880 @default.
- W4387600647 cites W1973276273 @default.
- W4387600647 cites W1985747467 @default.
- W4387600647 cites W1990709814 @default.
- W4387600647 cites W2003806841 @default.
- W4387600647 cites W2023487517 @default.
- W4387600647 cites W2024266852 @default.
- W4387600647 cites W2032444015 @default.
- W4387600647 cites W2038145816 @default.
- W4387600647 cites W2048685634 @default.
- W4387600647 cites W2052742260 @default.
- W4387600647 cites W2092674727 @default.
- W4387600647 cites W2093103671 @default.
- W4387600647 cites W2104282230 @default.
- W4387600647 cites W2124538980 @default.
- W4387600647 cites W2129030266 @default.
- W4387600647 cites W2136466563 @default.
- W4387600647 cites W2155210372 @default.
- W4387600647 cites W2166931244 @default.
- W4387600647 cites W2318463235 @default.
- W4387600647 cites W2625264145 @default.
- W4387600647 cites W2743131678 @default.
- W4387600647 cites W2789586078 @default.
- W4387600647 cites W2891373107 @default.
- W4387600647 cites W2902887888 @default.
- W4387600647 cites W2913978847 @default.
- W4387600647 cites W2924269600 @default.
- W4387600647 cites W2968840243 @default.
- W4387600647 cites W3003781481 @default.
- W4387600647 cites W3024317714 @default.
- W4387600647 cites W3037412948 @default.
- W4387600647 cites W3047731321 @default.
- W4387600647 cites W3162499653 @default.
- W4387600647 cites W3172795338 @default.
- W4387600647 cites W4206535643 @default.
- W4387600647 cites W4282927309 @default.
- W4387600647 cites W4285744937 @default.
- W4387600647 cites W4285802348 @default.
- W4387600647 cites W4307160336 @default.
- W4387600647 cites W4311261902 @default.
- W4387600647 cites W4376274112 @default.
- W4387600647 cites W4379053219 @default.
- W4387600647 cites W4385406189 @default.
- W4387600647 doi "https://doi.org/10.1016/j.exger.2023.112309" @default.
- W4387600647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37832802" @default.
- W4387600647 hasPublicationYear "2023" @default.
- W4387600647 type Work @default.
- W4387600647 citedByCount "0" @default.
- W4387600647 crossrefType "journal-article" @default.
- W4387600647 hasAuthorship W4387600647A5023393797 @default.
- W4387600647 hasAuthorship W4387600647A5031067860 @default.
- W4387600647 hasAuthorship W4387600647A5038499684 @default.
- W4387600647 hasAuthorship W4387600647A5067649805 @default.
- W4387600647 hasAuthorship W4387600647A5078573475 @default.
- W4387600647 hasAuthorship W4387600647A5083885486 @default.
- W4387600647 hasBestOaLocation W43876006471 @default.
- W4387600647 hasConcept C112592302 @default.
- W4387600647 hasConcept C126322002 @default.
- W4387600647 hasConcept C148762608 @default.
- W4387600647 hasConcept C15744967 @default.
- W4387600647 hasConcept C169760540 @default.
- W4387600647 hasConcept C170493617 @default.
- W4387600647 hasConcept C17077164 @default.
- W4387600647 hasConcept C197341189 @default.
- W4387600647 hasConcept C2778437258 @default.
- W4387600647 hasConcept C2779177108 @default.
- W4387600647 hasConcept C2780715579 @default.
- W4387600647 hasConcept C2781464450 @default.
- W4387600647 hasConcept C71924100 @default.
- W4387600647 hasConceptScore W4387600647C112592302 @default.
- W4387600647 hasConceptScore W4387600647C126322002 @default.
- W4387600647 hasConceptScore W4387600647C148762608 @default.
- W4387600647 hasConceptScore W4387600647C15744967 @default.
- W4387600647 hasConceptScore W4387600647C169760540 @default.
- W4387600647 hasConceptScore W4387600647C170493617 @default.
- W4387600647 hasConceptScore W4387600647C17077164 @default.
- W4387600647 hasConceptScore W4387600647C197341189 @default.
- W4387600647 hasConceptScore W4387600647C2778437258 @default.
- W4387600647 hasConceptScore W4387600647C2779177108 @default.
- W4387600647 hasConceptScore W4387600647C2780715579 @default.
- W4387600647 hasConceptScore W4387600647C2781464450 @default.
- W4387600647 hasConceptScore W4387600647C71924100 @default.