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• W4387601732 abstract "Parkinson's disease (PD) is a neurodegenerative disorder with motor deficits due to nigrostriatal dopamine depletion and with the non-motor/premotor symptoms (NMS) such as anxiety, cognitive dysfunction, depression, hyposmia, and sleep disorders. NMS is presented in at least one-fifth of the patients with PD. With the histological information being investigated, stem cells are shown to provide neurotrophic supports and cellular replacement in the damaging brain areas under PD conditions. Pathological change of progressive PD includes degeneration and loss of dopaminergic neurons in the substantia nigra of the midbrain. The current stem cell beneficial effect addresses dopamine boost for the striatal neurons and gliovascular mechanisms as competing for validated PD drug targets. In addition, there are clinical interventions for improving the patient's NMS and targeting their autonomic dysfunction, dementia, mood disorders, or sleep problems. In our and many others' research using brain injury models, multipotent mesenchymal stromal cells demonstrate an additional and unique ability to alleviate depressive-like behaviors, independent of an accelerated motor recovery. Intranasal delivery of the stem cells is discussed for it is extensively tested in rodent animal models of neurological and psychiatric disorders. In this review, we attempt to discuss the repairing potentials of transplanted cells into parkinsonism pathological regions of motor deficits and focus on preventive and treatment effects. From new approaches in the PD biological therapy, it is believed that it can as well benefit patients against PD-NMS." @default.
• W4387601732 created "2023-10-14" @default.
• W4387601732 creator A5004866432 @default.
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• W4387601732 creator A5070538018 @default.
• W4387601732 creator A5076699095 @default.
• W4387601732 date "2023-10-13" @default.
• W4387601732 modified "2023-10-16" @default.
• W4387601732 title "Mesenchymal stromal cell biotherapy for Parkinson’s disease premotor symptoms" @default.
• W4387601732 cites W1889981011 @default.
• W4387601732 cites W1974457187 @default.
• W4387601732 cites W1992607788 @default.
• W4387601732 cites W1993061207 @default.
• W4387601732 cites W2002930046 @default.
• W4387601732 cites W2017777484 @default.
• W4387601732 cites W2019010892 @default.
• W4387601732 cites W2028998458 @default.
• W4387601732 cites W2033298169 @default.
• W4387601732 cites W2033898517 @default.
• W4387601732 cites W2052029809 @default.
• W4387601732 cites W2093487214 @default.
• W4387601732 cites W2102182811 @default.
• W4387601732 cites W2168301899 @default.
• W4387601732 cites W2175697429 @default.
• W4387601732 cites W2213522310 @default.
• W4387601732 cites W2228895198 @default.
• W4387601732 cites W2314210898 @default.
• W4387601732 cites W2342546855 @default.
• W4387601732 cites W2347094772 @default.
• W4387601732 cites W2461435105 @default.
• W4387601732 cites W2511270757 @default.
• W4387601732 cites W2595085614 @default.
• W4387601732 cites W2601571152 @default.
• W4387601732 cites W2613217394 @default.
• W4387601732 cites W2623557053 @default.
• W4387601732 cites W2765546718 @default.
• W4387601732 cites W2767440265 @default.
• W4387601732 cites W2774604212 @default.
• W4387601732 cites W2793229726 @default.
• W4387601732 cites W2795340793 @default.
• W4387601732 cites W2808573277 @default.
• W4387601732 cites W2810319707 @default.
• W4387601732 cites W2811495931 @default.
• W4387601732 cites W2896097526 @default.
• W4387601732 cites W2908548900 @default.
• W4387601732 cites W2912776000 @default.
• W4387601732 cites W2947276475 @default.
• W4387601732 cites W2966474256 @default.
• W4387601732 cites W2978193416 @default.
• W4387601732 cites W2985384415 @default.
• W4387601732 cites W3005720713 @default.
• W4387601732 cites W3009059975 @default.
• W4387601732 cites W3010275327 @default.
• W4387601732 cites W3011380217 @default.
• W4387601732 cites W3012664261 @default.
• W4387601732 cites W3018690753 @default.
• W4387601732 cites W3020929916 @default.
• W4387601732 cites W3021740815 @default.
• W4387601732 cites W3029385222 @default.
• W4387601732 cites W3042050487 @default.
• W4387601732 cites W3042419041 @default.
• W4387601732 cites W3044491460 @default.
• W4387601732 cites W3082814429 @default.
• W4387601732 cites W3083590457 @default.
• W4387601732 cites W3103208279 @default.
• W4387601732 cites W3109606534 @default.
• W4387601732 cites W3109982843 @default.
• W4387601732 cites W3116043304 @default.
• W4387601732 cites W3126225762 @default.
• W4387601732 cites W3149671145 @default.
• W4387601732 cites W3150817550 @default.
• W4387601732 cites W3174664487 @default.
• W4387601732 cites W3175274971 @default.
• W4387601732 cites W3182012821 @default.
• W4387601732 cites W3184168768 @default.
• W4387601732 cites W3187910293 @default.
• W4387601732 cites W3203028993 @default.
• W4387601732 cites W4205675655 @default.
• W4387601732 cites W4221127764 @default.
• W4387601732 cites W4224254778 @default.
• W4387601732 cites W4229443157 @default.
• W4387601732 cites W4244819648 @default.
• W4387601732 cites W4251358880 @default.
• W4387601732 cites W4281950790 @default.
• W4387601732 cites W4283592561 @default.
• W4387601732 cites W4285181211 @default.
• W4387601732 cites W4286470608 @default.
• W4387601732 cites W4287881873 @default.
• W4387601732 cites W4289667141 @default.
• W4387601732 cites W4289979044 @default.
• W4387601732 cites W4291278346 @default.
• W4387601732 cites W4292370827 @default.
• W4387601732 cites W4294879017 @default.
• W4387601732 cites W4297256905 @default.

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