Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387602468> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W4387602468 abstract "<div>Abstract<p>Understanding the rewired metabolism underlying organ-specific metastasis in breast cancer could help identify strategies to improve the treatment and prevention of metastatic disease. Here, we used a systems biology approach to compare metabolic fluxes used by parental breast cancer cells and their brain- and lung-homing derivatives. Divergent lineages had distinct, heritable metabolic fluxes. Lung-homing cells maintained high glycolytic flux despite low levels of glycolytic intermediates, constitutively activating a pathway sink into lactate. This strong Warburg effect was associated with a high ratio of lactate dehydrogenase (LDH) to pyruvate dehydrogenase (PDH) expression, which correlated with lung metastasis in patients with breast cancer. Although feature classification models trained on clinical characteristics alone were unable to predict tropism, the LDH/PDH ratio was a significant predictor of metastasis to the lung but not to other organs, independent of other transcriptomic signatures. High lactate efflux was also a trait in lung-homing metastatic pancreatic cancer cells, suggesting that lactate production may be a convergent phenotype in lung metastasis. Together, these analyses highlight the essential role that metabolism plays in organ-specific cancer metastasis and identify a putative biomarker for predicting lung metastasis in patients with breast cancer.</p>Significance:<p>Lung-homing metastatic breast cancer cells express an elevated ratio of lactate dehydrogenase to pyruvate dehydrogenase, indicating that ratios of specific metabolic gene transcripts have potential as metabolic biomarkers for predicting organ-specific metastasis.</p></div>" @default.
- W4387602468 created "2023-10-14" @default.
- W4387602468 creator A5000272110 @default.
- W4387602468 creator A5023263135 @default.
- W4387602468 creator A5028819015 @default.
- W4387602468 creator A5040011658 @default.
- W4387602468 creator A5051379791 @default.
- W4387602468 creator A5053780327 @default.
- W4387602468 creator A5056591256 @default.
- W4387602468 creator A5073735612 @default.
- W4387602468 creator A5088995429 @default.
- W4387602468 creator A5089087198 @default.
- W4387602468 date "2023-10-13" @default.
- W4387602468 modified "2023-10-15" @default.
- W4387602468 title "Data from The Ratio of Key Metabolic Transcripts Is a Predictive Biomarker of Breast Cancer Metastasis to the Lung" @default.
- W4387602468 doi "https://doi.org/10.1158/0008-5472.c.6879369" @default.
- W4387602468 hasPublicationYear "2023" @default.
- W4387602468 type Work @default.
- W4387602468 citedByCount "0" @default.
- W4387602468 crossrefType "posted-content" @default.
- W4387602468 hasAuthorship W4387602468A5000272110 @default.
- W4387602468 hasAuthorship W4387602468A5023263135 @default.
- W4387602468 hasAuthorship W4387602468A5028819015 @default.
- W4387602468 hasAuthorship W4387602468A5040011658 @default.
- W4387602468 hasAuthorship W4387602468A5051379791 @default.
- W4387602468 hasAuthorship W4387602468A5053780327 @default.
- W4387602468 hasAuthorship W4387602468A5056591256 @default.
- W4387602468 hasAuthorship W4387602468A5073735612 @default.
- W4387602468 hasAuthorship W4387602468A5088995429 @default.
- W4387602468 hasAuthorship W4387602468A5089087198 @default.
- W4387602468 hasConcept C109156525 @default.
- W4387602468 hasConcept C121608353 @default.
- W4387602468 hasConcept C126322002 @default.
- W4387602468 hasConcept C134018914 @default.
- W4387602468 hasConcept C181199279 @default.
- W4387602468 hasConcept C20251656 @default.
- W4387602468 hasConcept C2775930923 @default.
- W4387602468 hasConcept C2776256026 @default.
- W4387602468 hasConcept C2777318727 @default.
- W4387602468 hasConcept C2779013556 @default.
- W4387602468 hasConcept C2781197716 @default.
- W4387602468 hasConcept C502942594 @default.
- W4387602468 hasConcept C530470458 @default.
- W4387602468 hasConcept C54355233 @default.
- W4387602468 hasConcept C55493867 @default.
- W4387602468 hasConcept C62231903 @default.
- W4387602468 hasConcept C71924100 @default.
- W4387602468 hasConcept C86803240 @default.
- W4387602468 hasConceptScore W4387602468C109156525 @default.
- W4387602468 hasConceptScore W4387602468C121608353 @default.
- W4387602468 hasConceptScore W4387602468C126322002 @default.
- W4387602468 hasConceptScore W4387602468C134018914 @default.
- W4387602468 hasConceptScore W4387602468C181199279 @default.
- W4387602468 hasConceptScore W4387602468C20251656 @default.
- W4387602468 hasConceptScore W4387602468C2775930923 @default.
- W4387602468 hasConceptScore W4387602468C2776256026 @default.
- W4387602468 hasConceptScore W4387602468C2777318727 @default.
- W4387602468 hasConceptScore W4387602468C2779013556 @default.
- W4387602468 hasConceptScore W4387602468C2781197716 @default.
- W4387602468 hasConceptScore W4387602468C502942594 @default.
- W4387602468 hasConceptScore W4387602468C530470458 @default.
- W4387602468 hasConceptScore W4387602468C54355233 @default.
- W4387602468 hasConceptScore W4387602468C55493867 @default.
- W4387602468 hasConceptScore W4387602468C62231903 @default.
- W4387602468 hasConceptScore W4387602468C71924100 @default.
- W4387602468 hasConceptScore W4387602468C86803240 @default.
- W4387602468 hasLocation W43876024681 @default.
- W4387602468 hasOpenAccess W4387602468 @default.
- W4387602468 hasPrimaryLocation W43876024681 @default.
- W4387602468 hasRelatedWork W1762294967 @default.
- W4387602468 hasRelatedWork W2035196020 @default.
- W4387602468 hasRelatedWork W2038440288 @default.
- W4387602468 hasRelatedWork W2044864652 @default.
- W4387602468 hasRelatedWork W2056444349 @default.
- W4387602468 hasRelatedWork W2383032683 @default.
- W4387602468 hasRelatedWork W2405190761 @default.
- W4387602468 hasRelatedWork W2517394834 @default.
- W4387602468 hasRelatedWork W2759858864 @default.
- W4387602468 hasRelatedWork W3145560974 @default.
- W4387602468 isParatext "false" @default.
- W4387602468 isRetracted "false" @default.
- W4387602468 workType "article" @default.