Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387603459> ?p ?o ?g. }
- W4387603459 abstract "Background: Lawsone (2-hydroxy-1,4-naphthoquinone) is naturally present in Lawsonia Inermis and flowers of Eicchornia crassipes . This study assessed the anti-arthritic potential of Lawsone, using FCA-induced Sprague-Dawley rats. Methods: Arthritic progress was analyzed through a macroscopic scoring scale, measurement of paw edema, and histopathological changes. Effects of Lawsone on mRNA expression levels of inflammatory markers were examined using the reverse transcription PCR technique. ELISA technique was used to evaluate the PGE2 levels. Moreover, levels of biochemical and hematological parameters were also analyzed. Results: The research elucidated that Lawsone showed an inhibitory potential towards arthritic progress and ameliorated the paw edema. The histopathological analysis also validated the inhibition in arthritic development. Treatment with Lawosne reduced the expression levels of inflammatory markers in rats i.e., VEGF, TNF-α, MMP-2, MMP-3, NF-κB, IL-1β, and IL-6. PGE2 levels (all p < 0.001) were also found reduced in treatment groups. Lab investigations showed improved results of hematological and hepatic parameters in the treated groups as compared to the positive control. This study found no hepatotoxic or nephrotoxic effects of Lawsone in the test doses. Conclusion: Lawsone possesses an anti-arthritic property which could be ascribed to its immunomodulatory and anti-inflammatory effects." @default.
- W4387603459 created "2023-10-14" @default.
- W4387603459 creator A5021198709 @default.
- W4387603459 creator A5021674873 @default.
- W4387603459 creator A5024682956 @default.
- W4387603459 creator A5031834080 @default.
- W4387603459 creator A5033065764 @default.
- W4387603459 creator A5057273932 @default.
- W4387603459 creator A5062575751 @default.
- W4387603459 creator A5065158631 @default.
- W4387603459 creator A5068005974 @default.
- W4387603459 creator A5093056261 @default.
- W4387603459 date "2023-10-13" @default.
- W4387603459 modified "2023-10-17" @default.
- W4387603459 title "Evaluation of anti-inflammatory and immunomodulatory potential of Lawsone (2-hydroxy-1,4-naphthoquinone) using pre-clinical rodent model of rheumatoid arthritis" @default.
- W4387603459 cites W1974276156 @default.
- W4387603459 cites W1978205743 @default.
- W4387603459 cites W1980464290 @default.
- W4387603459 cites W1980906720 @default.
- W4387603459 cites W1997465846 @default.
- W4387603459 cites W2010802338 @default.
- W4387603459 cites W2021252940 @default.
- W4387603459 cites W2040781140 @default.
- W4387603459 cites W2044468372 @default.
- W4387603459 cites W2046341828 @default.
- W4387603459 cites W2051297979 @default.
- W4387603459 cites W2052860737 @default.
- W4387603459 cites W2068677696 @default.
- W4387603459 cites W2071506642 @default.
- W4387603459 cites W2082562728 @default.
- W4387603459 cites W2087631918 @default.
- W4387603459 cites W2091055562 @default.
- W4387603459 cites W2092810179 @default.
- W4387603459 cites W2093440953 @default.
- W4387603459 cites W2103567384 @default.
- W4387603459 cites W2103927530 @default.
- W4387603459 cites W2121932492 @default.
- W4387603459 cites W2128952666 @default.
- W4387603459 cites W2135188547 @default.
- W4387603459 cites W2151566241 @default.
- W4387603459 cites W2160778065 @default.
- W4387603459 cites W2163447382 @default.
- W4387603459 cites W2513881796 @default.
- W4387603459 cites W2519293830 @default.
- W4387603459 cites W2607998356 @default.
- W4387603459 cites W2621445574 @default.
- W4387603459 cites W2738687551 @default.
- W4387603459 cites W2772571713 @default.
- W4387603459 cites W2803973097 @default.
- W4387603459 cites W2803975545 @default.
- W4387603459 cites W2809142686 @default.
- W4387603459 cites W2896285785 @default.
- W4387603459 cites W2903371431 @default.
- W4387603459 cites W2921167467 @default.
- W4387603459 cites W2928337649 @default.
- W4387603459 cites W2950259625 @default.
- W4387603459 cites W2962176031 @default.
- W4387603459 cites W2973152132 @default.
- W4387603459 cites W3002498794 @default.
- W4387603459 cites W3098382608 @default.
- W4387603459 cites W3113298942 @default.
- W4387603459 cites W3171954900 @default.
- W4387603459 cites W3202122821 @default.
- W4387603459 cites W3209722108 @default.
- W4387603459 cites W4221137754 @default.
- W4387603459 cites W4225985492 @default.
- W4387603459 cites W4290659572 @default.
- W4387603459 cites W4294755189 @default.
- W4387603459 cites W4321166025 @default.
- W4387603459 cites W4386423634 @default.
- W4387603459 doi "https://doi.org/10.3389/fphar.2023.1279215" @default.
- W4387603459 hasPublicationYear "2023" @default.
- W4387603459 type Work @default.
- W4387603459 citedByCount "0" @default.
- W4387603459 crossrefType "journal-article" @default.
- W4387603459 hasAuthorship W4387603459A5021198709 @default.
- W4387603459 hasAuthorship W4387603459A5021674873 @default.
- W4387603459 hasAuthorship W4387603459A5024682956 @default.
- W4387603459 hasAuthorship W4387603459A5031834080 @default.
- W4387603459 hasAuthorship W4387603459A5033065764 @default.
- W4387603459 hasAuthorship W4387603459A5057273932 @default.
- W4387603459 hasAuthorship W4387603459A5062575751 @default.
- W4387603459 hasAuthorship W4387603459A5065158631 @default.
- W4387603459 hasAuthorship W4387603459A5068005974 @default.
- W4387603459 hasAuthorship W4387603459A5093056261 @default.
- W4387603459 hasBestOaLocation W43876034591 @default.
- W4387603459 hasConcept C142724271 @default.
- W4387603459 hasConcept C178790620 @default.
- W4387603459 hasConcept C185592680 @default.
- W4387603459 hasConcept C203014093 @default.
- W4387603459 hasConcept C2776183150 @default.
- W4387603459 hasConcept C2776914184 @default.
- W4387603459 hasConcept C2777118608 @default.
- W4387603459 hasConcept C2779703632 @default.
- W4387603459 hasConcept C2780200714 @default.
- W4387603459 hasConcept C55493867 @default.
- W4387603459 hasConcept C71924100 @default.
- W4387603459 hasConcept C98274493 @default.
- W4387603459 hasConceptScore W4387603459C142724271 @default.
- W4387603459 hasConceptScore W4387603459C178790620 @default.