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- W4387603944 abstract "This article emphasizes the importance of prodrugs and their diverse spectrum of effects in the field of developing novel drugs for a variety of biological applications. For the purpose of illustrating the usefulness of the prodrug approach, this review covers examples of prodrugs that have been made available or are now undergoing human trials. Additionally, it included lists of the most common functional groups, carrier linkage, and reactive chemicals that can be used to create prodrugs. The primary chemical carriers employed in the creation of prodrugs, such as esters, amides, imides, NH-acidic carriers, amines, alcohols, carbonyl, carboxylic, and azo linkage, are also discussed. This review also discusses glycosidic and triglyceride mutually activated prodrugs, which aim to deliver the drugs after bioconversion at the intended site of action. The article also discusses the extensive chemistry and wide variety of applications of recently approved prodrugs, such as antibacterial, anti-inflammatory, cardiovascular, antiplatelet, antihypertensive, atherosclerotic, and antiviral, etc. In order to illustrate the prodrug and mutual drugs concept's various applications and highlight its many triumphs in overcoming the formulation and delivery of problematic pharmaceuticals, this work represents a thorough guide that includes the synthetic moiety to the reader." @default.
- W4387603944 created "2023-10-14" @default.
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- W4387603944 date "2023-10-13" @default.
- W4387603944 modified "2023-10-16" @default.
- W4387603944 title "Prodrug Rewards in Medicinal Chemistry: An Advance and Challenges Approach for Drug Designing" @default.
- W4387603944 doi "https://doi.org/10.1002/cbdv.202301169" @default.
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