FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387605314> ?p ?o ?g. }

• W4387605314 abstract "Abstract In clinical practice, renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI), often leading to acute renal failure or end-stage renal disease (ESRD). The current understanding of renal IRI mechanisms remains unclear, and effective therapeutic strategies and clear targets are lacking. Therefore, the need to find explicit and effective ways to reduce renal IRI remains a scientific challenge. The current study explored pyroptosis, a type of inflammation-regulated programmed cell death, and the role of Gasdermins E (GSDME)-mediated pyroptosis, mitochondrial damage, and inflammation in renal IRI. The analysis of human samples showed that the expression levels of GSDME in normal human renal tissues were higher than those of GSDMD. Moreover, our study demonstrated that GSDME played an important role in mediating pyroptosis, inflammation, and mitochondrial damage in renal IRI. Subsequently, GSDME-N accumulated in the mitochondrial membrane, leading to mitochondrial damage and activation of caspase3, which generated a feed-forward loop of self-amplification injury. However, GSDME knockout resulted in the amelioration of renal IRI. Moreover, at the low expression levels of GSDME, activated caspase3 mediated apoptosis, while at the high expression levels of GSDME, apoptosis was switched to pyroptosis. The current study found that the transcription factor CHOP was activated much earlier in renal IRI. On one hand, CHOP inhibited BCL-2, leading to mitochondrial damage and apoptosis, while on the other hand, it was positively regulated GSDME expression, enabling the conversion of apoptosis to pyroptosis.Therefore, this study explored the transcriptional mechanisms of GSDME during IRI development and the important role of CHOP/Caspase3/GSDME mechanistic axis in regulating apoptosis and pyroptosis in renal IRI. This axis might serve as a potential therapeutic target." @default.
• W4387605314 created "2023-10-14" @default.
• W4387605314 creator A5000990003 @default.
• W4387605314 creator A5003421579 @default.
• W4387605314 creator A5009017248 @default.
• W4387605314 creator A5011482358 @default.
• W4387605314 creator A5035701638 @default.
• W4387605314 creator A5038701581 @default.
• W4387605314 creator A5045335230 @default.
• W4387605314 creator A5050277723 @default.
• W4387605314 creator A5057055806 @default.
• W4387605314 date "2023-10-14" @default.
• W4387605314 modified "2023-10-17" @default.
• W4387605314 title "CHOP-mediated Gasdermin E expression promotes pyroptosis, inflammation, and mitochondrial damage in renal ischemia-reperfusion injury" @default.
• W4387605314 cites W1550684847 @default.
• W4387605314 cites W1864325817 @default.
• W4387605314 cites W1882905539 @default.
• W4387605314 cites W1970837608 @default.
• W4387605314 cites W1985970823 @default.
• W4387605314 cites W2016988352 @default.
• W4387605314 cites W2025511820 @default.
• W4387605314 cites W2068619092 @default.
• W4387605314 cites W2109265522 @default.
• W4387605314 cites W2131419242 @default.
• W4387605314 cites W2162274782 @default.
• W4387605314 cites W2165401602 @default.
• W4387605314 cites W2560541542 @default.
• W4387605314 cites W2564122215 @default.
• W4387605314 cites W2580286267 @default.
• W4387605314 cites W2608687752 @default.
• W4387605314 cites W2900460035 @default.
• W4387605314 cites W2907544909 @default.
• W4387605314 cites W2918568966 @default.
• W4387605314 cites W2936083981 @default.
• W4387605314 cites W2936615092 @default.
• W4387605314 cites W2983652778 @default.
• W4387605314 cites W2999767968 @default.
• W4387605314 cites W3095202855 @default.
• W4387605314 cites W3112774972 @default.
• W4387605314 cites W3134653743 @default.
• W4387605314 cites W3142080073 @default.
• W4387605314 cites W3161208341 @default.
• W4387605314 cites W3204842129 @default.
• W4387605314 cites W3205681349 @default.
• W4387605314 cites W4212921153 @default.
• W4387605314 cites W4214538340 @default.
• W4387605314 cites W4285094966 @default.
• W4387605314 cites W4296027835 @default.
• W4387605314 cites W4312094691 @default.
• W4387605314 cites W4321331233 @default.
• W4387605314 doi "https://doi.org/10.21203/rs.3.rs-3380049/v1" @default.
• W4387605314 hasPublicationYear "2023" @default.
• W4387605314 type Work @default.
• W4387605314 citedByCount "0" @default.
• W4387605314 crossrefType "posted-content" @default.
• W4387605314 hasAuthorship W4387605314A5000990003 @default.
• W4387605314 hasAuthorship W4387605314A5003421579 @default.
• W4387605314 hasAuthorship W4387605314A5009017248 @default.
• W4387605314 hasAuthorship W4387605314A5011482358 @default.
• W4387605314 hasAuthorship W4387605314A5035701638 @default.
• W4387605314 hasAuthorship W4387605314A5038701581 @default.
• W4387605314 hasAuthorship W4387605314A5045335230 @default.
• W4387605314 hasAuthorship W4387605314A5050277723 @default.
• W4387605314 hasAuthorship W4387605314A5057055806 @default.
• W4387605314 hasBestOaLocation W43876053141 @default.
• W4387605314 hasConcept C126322002 @default.
• W4387605314 hasConcept C17172800 @default.
• W4387605314 hasConcept C190283241 @default.
• W4387605314 hasConcept C2776914184 @default.
• W4387605314 hasConcept C2777209026 @default.
• W4387605314 hasConcept C2779725641 @default.
• W4387605314 hasConcept C2780091579 @default.
• W4387605314 hasConcept C2780114680 @default.
• W4387605314 hasConcept C2780721119 @default.
• W4387605314 hasConcept C31573885 @default.
• W4387605314 hasConcept C502942594 @default.
• W4387605314 hasConcept C541997718 @default.
• W4387605314 hasConcept C55493867 @default.
• W4387605314 hasConcept C71924100 @default.
• W4387605314 hasConcept C86803240 @default.
• W4387605314 hasConceptScore W4387605314C126322002 @default.
• W4387605314 hasConceptScore W4387605314C17172800 @default.
• W4387605314 hasConceptScore W4387605314C190283241 @default.
• W4387605314 hasConceptScore W4387605314C2776914184 @default.
• W4387605314 hasConceptScore W4387605314C2777209026 @default.
• W4387605314 hasConceptScore W4387605314C2779725641 @default.
• W4387605314 hasConceptScore W4387605314C2780091579 @default.
• W4387605314 hasConceptScore W4387605314C2780114680 @default.
• W4387605314 hasConceptScore W4387605314C2780721119 @default.
• W4387605314 hasConceptScore W4387605314C31573885 @default.
• W4387605314 hasConceptScore W4387605314C502942594 @default.
• W4387605314 hasConceptScore W4387605314C541997718 @default.
• W4387605314 hasConceptScore W4387605314C55493867 @default.
• W4387605314 hasConceptScore W4387605314C71924100 @default.
• W4387605314 hasConceptScore W4387605314C86803240 @default.
• W4387605314 hasLocation W43876053141 @default.
• W4387605314 hasOpenAccess W4387605314 @default.
• W4387605314 hasPrimaryLocation W43876053141 @default.
• W4387605314 hasRelatedWork W2343760032 @default.
• W4387605314 hasRelatedWork W2600940366 @default.

• next