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- W4387606953 abstract "The development of x-ray free electron laser (XFEL) light sources and serial crystallography methodologies has led to a revolution in protein crystallography, enabling the determination of previously unobtainable protein structures and near-atomic resolution of otherwise poorly diffracting protein crystals. However, to utilize XFEL sources efficiently demands the continuous, rapid delivery of a large number of difficult-to-handle microcrystals to the x-ray beam. A recently developed fixed-target system, in which crystals of interest are enclosed within a sample holder, which is rastered through the x-ray beam, is discussed in detail in this Perspective. The fixed target is easy to use, maintains sample hydration, and can be readily modified to allow a broad range of sample types and different beamline requirements. Recent innovations demonstrate the potential of such microfluidic-based fixed targets to be an all-around workhorse for serial crystallography measurements. This Perspective will summarize recent advancements in microfluidic fixed targets for serial crystallography, examine needs for future development, and guide users in designing, choosing, and utilizing a fixed-target sample delivery device for their system." @default.
- W4387606953 created "2023-10-14" @default.
- W4387606953 creator A5019080085 @default.
- W4387606953 creator A5026787127 @default.
- W4387606953 creator A5082234024 @default.
- W4387606953 creator A5083019022 @default.
- W4387606953 creator A5086179935 @default.
- W4387606953 creator A5086803075 @default.
- W4387606953 creator A5087571156 @default.
- W4387606953 creator A5088825231 @default.
- W4387606953 date "2023-09-01" @default.
- W4387606953 modified "2023-10-18" @default.
- W4387606953 title "All polymer microfluidic chips—A fixed target sample delivery workhorse for serial crystallography" @default.
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