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- W4387607550 abstract "INTRODUCTION: The extent to which the Big Five personality traits and subjective well-being (SWB) are discriminatory predictors of clinical manifestation of dementia versus dementia-related neuropathology is unclear. METHODS: Using data from eight independent studies (Ntotal=44,531; Ndementia=1703; baseline Mage=49-81 years, 26-61% female; Mfollow-up range=3.53-21.00 years), Bayesian multilevel models tested whether personality traits and SWB differentially predicted neuropsychological and neuropathological characteristics of dementia.RESULTS: Synthesized and individual study results indicate that high neuroticism and negative affect and low conscientiousness, extraversion, and positive affect were associated with increased risk of long-term dementia diagnosis. There were no consistent associations with neuropathology.DISCUSSION: This multi-study project provides robust, conceptually replicated and extended evidence that psychosocial factors are strong predictors of dementia diagnosis but not consistently associated with neuropathology at autopsy." @default.
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- W4387607550 date "2023-10-12" @default.
- W4387607550 modified "2023-10-14" @default.
- W4387607550 title "Personality Predictors of Dementia Diagnosis and Neuropathological Burden: An Individual Participant Data Meta-Analysis" @default.
- W4387607550 doi "https://doi.org/10.31234/osf.io/gbc6s" @default.
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