Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387607773> ?p ?o ?g. }
- W4387607773 endingPage "2549" @default.
- W4387607773 startingPage "2549" @default.
- W4387607773 abstract "Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) syndrome is one of the most controversial diseases in pediatric rheumatology. Despite first being described more than 25 years ago as the sudden and rapid onset of obsessive–compulsive disorder (OCD) and/or tic disorder symptoms as complications of a Group A beta-hemolytic Streptococcus (GAS) infection, precise epidemiological data are still lacking, and there are no strong recommendations for its treatment. Recent advances in the comprehension of PANDAS pathophysiology are largely attributable to animal model studies and the understanding of the roles of Ca++/calmodulin-dependent protein kinase (CaM kinase) II, disrupted dopamine release in the basal ganglia, and striatal cholinergic interneurons. The diagnosis of PANDAS should be made after an exclusion process and should include prepubescent children with a sudden onset of OCD and/or a tic disorder, with a relapsing/remitting disease course, a clear temporal association between GAS infection and onset or exacerbation of symptoms, and the association with other neurological abnormalities such as motoric hyperactivity and choreiform movements. Antibiotic medications are the primary therapeutic modality. Nonetheless, there is a paucity of randomized studies and validated data, resulting in a scarcity of solid recommendations." @default.
- W4387607773 created "2023-10-14" @default.
- W4387607773 creator A5001148659 @default.
- W4387607773 creator A5012201056 @default.
- W4387607773 creator A5039110091 @default.
- W4387607773 creator A5060518463 @default.
- W4387607773 creator A5077451775 @default.
- W4387607773 creator A5079549126 @default.
- W4387607773 creator A5081526736 @default.
- W4387607773 creator A5082347131 @default.
- W4387607773 creator A5087684524 @default.
- W4387607773 date "2023-10-13" @default.
- W4387607773 modified "2023-10-14" @default.
- W4387607773 title "Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS): Myth or Reality? The State of the Art on a Controversial Disease" @default.
- W4387607773 cites W1566249398 @default.
- W4387607773 cites W1972859381 @default.
- W4387607773 cites W1983177951 @default.
- W4387607773 cites W1990682046 @default.
- W4387607773 cites W1991304179 @default.
- W4387607773 cites W1991448189 @default.
- W4387607773 cites W2002182743 @default.
- W4387607773 cites W2009104560 @default.
- W4387607773 cites W2009716244 @default.
- W4387607773 cites W2012943713 @default.
- W4387607773 cites W2018329843 @default.
- W4387607773 cites W2021062396 @default.
- W4387607773 cites W2025586896 @default.
- W4387607773 cites W2029832309 @default.
- W4387607773 cites W2050000178 @default.
- W4387607773 cites W2050647926 @default.
- W4387607773 cites W2059668493 @default.
- W4387607773 cites W2059724043 @default.
- W4387607773 cites W2067549157 @default.
- W4387607773 cites W2069559093 @default.
- W4387607773 cites W2076027411 @default.
- W4387607773 cites W2083156156 @default.
- W4387607773 cites W2083546450 @default.
- W4387607773 cites W2083870582 @default.
- W4387607773 cites W2084977697 @default.
- W4387607773 cites W2085338730 @default.
- W4387607773 cites W2085430427 @default.
- W4387607773 cites W2089889142 @default.
- W4387607773 cites W2090731719 @default.
- W4387607773 cites W2094776093 @default.
- W4387607773 cites W2098965252 @default.
- W4387607773 cites W2111453841 @default.
- W4387607773 cites W2121940372 @default.
- W4387607773 cites W2125264386 @default.
- W4387607773 cites W2130081862 @default.
- W4387607773 cites W2133887970 @default.
- W4387607773 cites W2134804020 @default.
- W4387607773 cites W2141283639 @default.
- W4387607773 cites W2147320841 @default.
- W4387607773 cites W2152208438 @default.
- W4387607773 cites W2153582278 @default.
- W4387607773 cites W2153620991 @default.
- W4387607773 cites W2156107325 @default.
- W4387607773 cites W2159628080 @default.
- W4387607773 cites W2161140251 @default.
- W4387607773 cites W2164643225 @default.
- W4387607773 cites W2167801980 @default.
- W4387607773 cites W2276803347 @default.
- W4387607773 cites W2497571000 @default.
- W4387607773 cites W2502540799 @default.
- W4387607773 cites W2582874622 @default.
- W4387607773 cites W2584951684 @default.
- W4387607773 cites W2587887764 @default.
- W4387607773 cites W2619905524 @default.
- W4387607773 cites W2738337914 @default.
- W4387607773 cites W2739432511 @default.
- W4387607773 cites W2739465988 @default.
- W4387607773 cites W2767479224 @default.
- W4387607773 cites W2780252970 @default.
- W4387607773 cites W2782036299 @default.
- W4387607773 cites W2799784712 @default.
- W4387607773 cites W2896693962 @default.
- W4387607773 cites W2903577630 @default.
- W4387607773 cites W2911523096 @default.
- W4387607773 cites W2914310830 @default.
- W4387607773 cites W2940729693 @default.
- W4387607773 cites W3006986395 @default.
- W4387607773 cites W3034700508 @default.
- W4387607773 cites W3110391839 @default.
- W4387607773 cites W3210438722 @default.
- W4387607773 cites W4210479452 @default.
- W4387607773 cites W4309126472 @default.
- W4387607773 cites W4378083047 @default.
- W4387607773 cites W4386272428 @default.
- W4387607773 cites W93215865 @default.
- W4387607773 cites W2146053279 @default.
- W4387607773 doi "https://doi.org/10.3390/microorganisms11102549" @default.
- W4387607773 hasPublicationYear "2023" @default.
- W4387607773 type Work @default.
- W4387607773 citedByCount "0" @default.
- W4387607773 crossrefType "journal-article" @default.
- W4387607773 hasAuthorship W4387607773A5001148659 @default.
- W4387607773 hasAuthorship W4387607773A5012201056 @default.
- W4387607773 hasAuthorship W4387607773A5039110091 @default.