Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387608214> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4387608214 abstract "<div>AbstractPurpose:<p>CA19–9 synthesis is influenced by common variants in the fucosyltransferase (FUT) enzymes FUT3 and FUT2. We developed a clinical test to detect FUT variants, and evaluated its diagnostic performance for pancreatic ductal adenocarcinoma (PDAC).</p>Experimental Design:<p>A representative set of controls from the Cancer of the Pancreas Screening study was identified for each FUT functional group. Diagnostic sensitivity was determined first in a testing set of 234 PDAC cases, followed by a 134-case validation set, all of whom had undergone resection with curative intent without neoadjuvant therapy. Tumor marker gene testing was performed in the Johns Hopkins Molecular Diagnostics Laboratory. CA19–9 levels were measured in the Hopkins Clinical Chemistry lab. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminative ability of CA19–9 alone versus with the gene test.</p>Results:<p>Applying the CA19–9 standard cutoff (<36 U/mL) to all 716 subjects yielded a 68.8% sensitivity in the test set of cases, 67.2% in the validation set, at 91.4% specificity. Applying 99th percentile cutoffs according to each individual's FUT group (3, 34.9, 41.8, and 89.2, for the FUT3-null, FUT-low, FUT-intermediate, and FUT-high groups, respectively) yielded a diagnostic sensitivity for CA19–9 in the first set of cases of 66.7%, 65.7% in the validation set, at 98.9% specificity. ROC analysis for CA19–9 alone yielded an AUC of 0.84; with the tumor marker gene test, AUC improved to 0.92 (<i>P</i> < 0.001).</p>Conclusions:<p>Using a tumor marker gene test to personalize an individual's CA19–9 reference range significantly improves diagnostic accuracy.</p></div>" @default.
- W4387608214 created "2023-10-14" @default.
- W4387608214 creator A5004897590 @default.
- W4387608214 creator A5012591920 @default.
- W4387608214 creator A5012986870 @default.
- W4387608214 creator A5027789575 @default.
- W4387608214 creator A5031696571 @default.
- W4387608214 creator A5033243138 @default.
- W4387608214 creator A5039731184 @default.
- W4387608214 creator A5039843730 @default.
- W4387608214 creator A5040603112 @default.
- W4387608214 creator A5044987088 @default.
- W4387608214 creator A5051663630 @default.
- W4387608214 creator A5057282543 @default.
- W4387608214 creator A5059394527 @default.
- W4387608214 creator A5059832377 @default.
- W4387608214 creator A5068955139 @default.
- W4387608214 creator A5078198832 @default.
- W4387608214 creator A5078973899 @default.
- W4387608214 creator A5092627609 @default.
- W4387608214 date "2023-10-13" @default.
- W4387608214 modified "2023-10-14" @default.
- W4387608214 title "Data from Diagnostic Performance of a Tumor Marker Gene Test to Personalize Serum CA19–9 Reference Ranges" @default.
- W4387608214 doi "https://doi.org/10.1158/1078-0432.c.6879411" @default.
- W4387608214 hasPublicationYear "2023" @default.
- W4387608214 type Work @default.
- W4387608214 citedByCount "0" @default.
- W4387608214 crossrefType "posted-content" @default.
- W4387608214 hasAuthorship W4387608214A5004897590 @default.
- W4387608214 hasAuthorship W4387608214A5012591920 @default.
- W4387608214 hasAuthorship W4387608214A5012986870 @default.
- W4387608214 hasAuthorship W4387608214A5027789575 @default.
- W4387608214 hasAuthorship W4387608214A5031696571 @default.
- W4387608214 hasAuthorship W4387608214A5033243138 @default.
- W4387608214 hasAuthorship W4387608214A5039731184 @default.
- W4387608214 hasAuthorship W4387608214A5039843730 @default.
- W4387608214 hasAuthorship W4387608214A5040603112 @default.
- W4387608214 hasAuthorship W4387608214A5044987088 @default.
- W4387608214 hasAuthorship W4387608214A5051663630 @default.
- W4387608214 hasAuthorship W4387608214A5057282543 @default.
- W4387608214 hasAuthorship W4387608214A5059394527 @default.
- W4387608214 hasAuthorship W4387608214A5059832377 @default.
- W4387608214 hasAuthorship W4387608214A5068955139 @default.
- W4387608214 hasAuthorship W4387608214A5078198832 @default.
- W4387608214 hasAuthorship W4387608214A5078973899 @default.
- W4387608214 hasAuthorship W4387608214A5092627609 @default.
- W4387608214 hasConcept C105795698 @default.
- W4387608214 hasConcept C121332964 @default.
- W4387608214 hasConcept C121608353 @default.
- W4387608214 hasConcept C122048520 @default.
- W4387608214 hasConcept C126322002 @default.
- W4387608214 hasConcept C143998085 @default.
- W4387608214 hasConcept C144369459 @default.
- W4387608214 hasConcept C2778217198 @default.
- W4387608214 hasConcept C2780210213 @default.
- W4387608214 hasConcept C33923547 @default.
- W4387608214 hasConcept C58471807 @default.
- W4387608214 hasConcept C62520636 @default.
- W4387608214 hasConcept C71924100 @default.
- W4387608214 hasConcept C90924648 @default.
- W4387608214 hasConceptScore W4387608214C105795698 @default.
- W4387608214 hasConceptScore W4387608214C121332964 @default.
- W4387608214 hasConceptScore W4387608214C121608353 @default.
- W4387608214 hasConceptScore W4387608214C122048520 @default.
- W4387608214 hasConceptScore W4387608214C126322002 @default.
- W4387608214 hasConceptScore W4387608214C143998085 @default.
- W4387608214 hasConceptScore W4387608214C144369459 @default.
- W4387608214 hasConceptScore W4387608214C2778217198 @default.
- W4387608214 hasConceptScore W4387608214C2780210213 @default.
- W4387608214 hasConceptScore W4387608214C33923547 @default.
- W4387608214 hasConceptScore W4387608214C58471807 @default.
- W4387608214 hasConceptScore W4387608214C62520636 @default.
- W4387608214 hasConceptScore W4387608214C71924100 @default.
- W4387608214 hasConceptScore W4387608214C90924648 @default.
- W4387608214 hasLocation W43876082141 @default.
- W4387608214 hasOpenAccess W4387608214 @default.
- W4387608214 hasPrimaryLocation W43876082141 @default.
- W4387608214 hasRelatedWork W1597180000 @default.
- W4387608214 hasRelatedWork W2063141849 @default.
- W4387608214 hasRelatedWork W2064775908 @default.
- W4387608214 hasRelatedWork W2068232962 @default.
- W4387608214 hasRelatedWork W2301258522 @default.
- W4387608214 hasRelatedWork W2356596975 @default.
- W4387608214 hasRelatedWork W2380673165 @default.
- W4387608214 hasRelatedWork W2414953816 @default.
- W4387608214 hasRelatedWork W2808579301 @default.
- W4387608214 hasRelatedWork W3014515283 @default.
- W4387608214 isParatext "false" @default.
- W4387608214 isRetracted "false" @default.
- W4387608214 workType "article" @default.