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- W4387608265 abstract "Abstract An animal’s ability to sense odors declines during aging, and its olfactory drive is tuned by internal states such as satiety. However, whether internal states modulate an age-dependent decline in odor sensation is unknown. To address this issue, we utilized the nematode Caenorhabditis elegans and compared their chemotaxis abilities toward attractive odorants when aged under different dietary conditions. Feeding with the standard laboratory diet, Escherichia coli attenuated the chemotaxis ability toward diacetyl, isoamyl alcohol, and benzaldehyde when aged. On the other hand, feeding with either the lactic acid bacteria Lactobacillus reuteri or food deprivation selectively maintained the chemotaxis ability toward diacetyl. Our results suggest that ingestion of E. coli causes age-dependent chemotaxis decline. The changes in chemotaxis behavior are attributed to the different expression of diacetyl receptor odr-10 , and chemotaxis behavior of aged animals under food deprivation is shown to be dependent on daf-16 . Our study demonstrates the molecular mechanism of how diet shapes the trajectory of age-dependent decline in chemosensory behaviors." @default.
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- W4387608265 date "2023-10-13" @default.
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- W4387608265 title "Dietary E. coli promotes age-dependent chemotaxis decline in C. elegans" @default.
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- W4387608265 doi "https://doi.org/10.21203/rs.3.rs-3411747/v1" @default.
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