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- W4387608718 abstract "Abstract Introduction：Nasopharyngeal carcinoma (NPC) is mostly associated with EBV infection, which often leads to poor prognosis and a high mortality rate of NPC patients due to the high susceptibility of NPC cells to local infiltration of lymph nodes and distant metastasis. Methods： This study aimed to evaluate the diagnostic value of serum BNLF2b for nasopharyngeal carcinoma. A total of 318 patients (male-to-female ratio: 200:118) were selected to attend the Zhongshan People's Hospital from December 2021 to May 2023, including 152 nasopharyngeal carcinoma patients, 71 healthy subjects in the physical examination center and 95 nasopharyngitis patients.Elbow venous blood was collected from all of patients, and the content of BNLF2b was determined after quantitative serum extraction.The diagnostic value of serum BNLF2b for nasopharyngeal carcinoma was analyzed using the subject's work characteristics (ROC) curve, and logistic two-factor regression analysis was used to predict the ROC curves of the risk factors for the development of nasopharyngeal carcinoma by the combined diagnosis of multiple indicators. Results：we found that serum BNLF2b was significantly and positively correlated with EBV-DNA, nasopharyngeal carcinoma stage, IL-6, and IL-10. Serum BNLF2b was highly efficient in the diagnosis of nasopharyngeal cancer, with an AUC of 0.92, a sensitivity of 99%, and a specificity of 93%. In addition, in the diagnosis of early nasopharyngeal carcinoma, serum BNLF2 had an AUC of 0.97, a sensitivity of 100%, and a specificity of 97%. Conclusion： BNLF2b is a feasible new serum biomarker for diagnosis of nasopharyngeal carcinoma." @default.
- W4387608718 created "2023-10-14" @default.
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- W4387608718 date "2023-10-13" @default.
- W4387608718 modified "2023-10-14" @default.
- W4387608718 title "Study on the diagnostic value of BNLF2b in nasopharyngeal carcinoma" @default.
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- W4387608718 doi "https://doi.org/10.21203/rs.3.rs-3372128/v1" @default.
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