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- W4387608766 abstract "To investigate the prognostic value of quantifying optical coherence tomography (OCT)-defined hyperreflective foci (HRF) that do not correspond to hyperpigmentary abnormalities (HPAs) on color fundus photographs (CFPs) - HRF(OCT+/CFP-)- when considered in addition to HPA extent, for predicting late age-related macular degeneration (AMD) development. We also sought to understand the impact of HRF(OCT+/CFP-) extent on visual sensitivity.280 eyes from 140 participants with bilateral large drusen underwent imaging and microperimetry at baseline, and then 6-monthly for 3-years. The extent of HPAs on CFPs and HRF(OCT+/CFP-) on OCT was quantified at baseline. Predictive models for progression to late AMD, accounting for drusen volume and age, were developed using HPA extent, with and without HRF(OCT+/CFP-) extent. The association between HPA and HRF(OCT+/CFP-) extent with sector-based visual sensitivity was also evaluated.Incorporating HRF(OCT+/CFP-) extent did not improve the predictive performance for late AMD development (P≥0.32). Increasing HPA and HRF(OCT+/CFP-) extent in each sector were independently and significantly associated with reduced sector-based visual sensitivity (P≤0.004).The addition of HRF(OCT+/CFP-) extent to HPA extent did not improve the prediction of late AMD development. HRF(OCT+/CFP-) extent was also independently associated with local reductions in visual sensitivity, after accounting for HPAs." @default.
- W4387608766 created "2023-10-14" @default.
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- W4387608766 date "2023-10-12" @default.
- W4387608766 modified "2023-10-15" @default.
- W4387608766 title "Hyperreflective Foci not seen as Hyperpigmentary Abnormalities on Color Fundus Photographs in Age-Related Macular Degeneration" @default.
- W4387608766 doi "https://doi.org/10.1097/iae.0000000000003958" @default.
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