Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387608869> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4387608869 abstract "Abstract Background: Patients admitted to the intensive care unit (ICU) following coronary artery bypass grafting (CABG) often experience abnormal levels of blood chloride. This study primarily aims to evaluate the association between blood-Cl – -levels and the likelihood of 30-day mortality in this cohort. The authors hypothesized that abnormal blood-Cl – -levels would increase 30-day mortality in these patients. Methods: The dataset for this research consists of patients who were over the age of 18 and underwent CABG procedures at two renowned establishments in the United States. These institutions are Beth Israel Deaconess Medical Center/Harvard Medical School, located in Boston, and Massachusetts Institute of Technology, situated in Cambridge. The data used in this retrospective cohort study spanned from 2008 to 2019 and were derived from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. Based on the tertiles of blood-Cl – -levels, the participants were divided into Q1, Q2, and Q3 groups. To investigate the association between blood-Cl – -levels and 30-day mortality, several statistical models were used, including a generalized additive model (GAM), restricted cubic spines (RCS), and a two-piecewise linear regression model. The 30-day mortality rates of the three groups were depicted using Kaplan–Meier (K–M) curves. Additionally, we employed multivariable logistic regression models to account for any potential known confounding factors. Results: Finally, in total, 5224 patients (mean age, 68.8 years; 77% male; 65.9% > 65 years of age) entered the analysis. The rates of 30-day mortality in Q1, Q2, and Q3 groups were 2.8%, 0.9%, and 1.0%, respectively ( p < 0.001). After adjusting for all latent known covariates, patients in the lower tertile exhibited an increased 30-day mortality risk (adjusted odds ratio [OR] 2.75 [95% confidence interval (CI) 1.32–5.73]; p = 0.017). The study concluded a nonlinear association between blood-Cl – -level and 30-day mortality, with a threshold at approximately 107.0 mmol/L. The effect sizes and their corresponding confidence intervals (CIs) below and above the threshold were as follows: 0.77 (0.67–0.87) and 1.15 (0.83–1.6), respectively. Conclusion: A nonlinear correlation was observed between the blood-Cl – -levels and the mortality rate within 30 days among patients admitted to the ICU following CABG procedures. Elevated and reduced blood-Cl – -levels were linked to higher rates of 30-day mortality, particularly when Cl – fell below the threshold of 107.0 mmol/L." @default.
- W4387608869 created "2023-10-14" @default.
- W4387608869 creator A5050355323 @default.
- W4387608869 creator A5057382778 @default.
- W4387608869 creator A5068178443 @default.
- W4387608869 creator A5082317830 @default.
- W4387608869 date "2023-10-13" @default.
- W4387608869 modified "2023-10-14" @default.
- W4387608869 title "Association between blood chloride levels and 30-day mortality in patients admitted to the intensive care unit after coronary artery bypass grafting: analysis of data from MIMIC-IV database" @default.
- W4387608869 cites W1956277079 @default.
- W4387608869 cites W2026274122 @default.
- W4387608869 cites W2059796825 @default.
- W4387608869 cites W2098939489 @default.
- W4387608869 cites W2118877698 @default.
- W4387608869 cites W2118981009 @default.
- W4387608869 cites W2120074411 @default.
- W4387608869 cites W2156965844 @default.
- W4387608869 cites W2312346632 @default.
- W4387608869 cites W2529785579 @default.
- W4387608869 cites W2573790752 @default.
- W4387608869 cites W2746623916 @default.
- W4387608869 cites W2757504960 @default.
- W4387608869 cites W2770474763 @default.
- W4387608869 cites W2788921336 @default.
- W4387608869 cites W2791384426 @default.
- W4387608869 cites W2794287819 @default.
- W4387608869 cites W2801701479 @default.
- W4387608869 cites W2899072082 @default.
- W4387608869 cites W2901405868 @default.
- W4387608869 cites W2946729916 @default.
- W4387608869 cites W3158257877 @default.
- W4387608869 cites W3199325928 @default.
- W4387608869 cites W4248153712 @default.
- W4387608869 cites W4292767157 @default.
- W4387608869 cites W4297496167 @default.
- W4387608869 cites W4313439128 @default.
- W4387608869 doi "https://doi.org/10.21203/rs.3.rs-3351429/v1" @default.
- W4387608869 hasPublicationYear "2023" @default.
- W4387608869 type Work @default.
- W4387608869 citedByCount "0" @default.
- W4387608869 crossrefType "posted-content" @default.
- W4387608869 hasAuthorship W4387608869A5050355323 @default.
- W4387608869 hasAuthorship W4387608869A5057382778 @default.
- W4387608869 hasAuthorship W4387608869A5068178443 @default.
- W4387608869 hasAuthorship W4387608869A5082317830 @default.
- W4387608869 hasBestOaLocation W43876088691 @default.
- W4387608869 hasConcept C126322002 @default.
- W4387608869 hasConcept C144024400 @default.
- W4387608869 hasConcept C149923435 @default.
- W4387608869 hasConcept C151956035 @default.
- W4387608869 hasConcept C167135981 @default.
- W4387608869 hasConcept C194828623 @default.
- W4387608869 hasConcept C201903717 @default.
- W4387608869 hasConcept C2776376669 @default.
- W4387608869 hasConcept C2776820930 @default.
- W4387608869 hasConcept C3017915907 @default.
- W4387608869 hasConcept C41008148 @default.
- W4387608869 hasConcept C50382708 @default.
- W4387608869 hasConcept C71924100 @default.
- W4387608869 hasConcept C72563966 @default.
- W4387608869 hasConcept C77088390 @default.
- W4387608869 hasConcept C77350462 @default.
- W4387608869 hasConceptScore W4387608869C126322002 @default.
- W4387608869 hasConceptScore W4387608869C144024400 @default.
- W4387608869 hasConceptScore W4387608869C149923435 @default.
- W4387608869 hasConceptScore W4387608869C151956035 @default.
- W4387608869 hasConceptScore W4387608869C167135981 @default.
- W4387608869 hasConceptScore W4387608869C194828623 @default.
- W4387608869 hasConceptScore W4387608869C201903717 @default.
- W4387608869 hasConceptScore W4387608869C2776376669 @default.
- W4387608869 hasConceptScore W4387608869C2776820930 @default.
- W4387608869 hasConceptScore W4387608869C3017915907 @default.
- W4387608869 hasConceptScore W4387608869C41008148 @default.
- W4387608869 hasConceptScore W4387608869C50382708 @default.
- W4387608869 hasConceptScore W4387608869C71924100 @default.
- W4387608869 hasConceptScore W4387608869C72563966 @default.
- W4387608869 hasConceptScore W4387608869C77088390 @default.
- W4387608869 hasConceptScore W4387608869C77350462 @default.
- W4387608869 hasLocation W43876088691 @default.
- W4387608869 hasOpenAccess W4387608869 @default.
- W4387608869 hasPrimaryLocation W43876088691 @default.
- W4387608869 hasRelatedWork W1504175559 @default.
- W4387608869 hasRelatedWork W2047001262 @default.
- W4387608869 hasRelatedWork W2365960022 @default.
- W4387608869 hasRelatedWork W2371350079 @default.
- W4387608869 hasRelatedWork W2376984207 @default.
- W4387608869 hasRelatedWork W2921052181 @default.
- W4387608869 hasRelatedWork W2965222450 @default.
- W4387608869 hasRelatedWork W3133341656 @default.
- W4387608869 hasRelatedWork W4214554109 @default.
- W4387608869 hasRelatedWork W4312675760 @default.
- W4387608869 isParatext "false" @default.
- W4387608869 isRetracted "false" @default.
- W4387608869 workType "article" @default.