Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387608879> ?p ?o ?g. }
- W4387608879 abstract "Adhesion G protein-coupled receptors (aGPCRs) have extracellular regions (ECRs) containing GPCR autoproteolysis-inducing (GAIN) domains. The GAIN domain enables the ECR to self-cleave into N- and C-terminal fragments. However, the impact of force on the GAIN domain's conformation, critical for mechanosensitive aGPCR activation, remains unclear. Our study investigated the mechanical stability of GAIN domains in three aGPCRs (B, G, and L subfamilies) at a loading rate of 1 pN/s. We discovered that forces of a few piconewtons can destabilize the GAIN domains. In autocleaved aGPCRs ADGRG1/GPR56 and ADGRL1/LPHN1, these forces cause the GAIN domain detachment from the membrane-proximal Stachel sequence, preceded by partial unfolding. In noncleavable aGPCR ADGRB3/BAI3 and cleavage-deficient mutant ADGRG1/GPR56-T383G, complex mechanical unfolding of the GAIN domain occurs. Additionally, GAIN domain detachment happens during cell migration. Our findings support the mechanical activation hypothesis of aGPCRs, emphasizing the sensitivity of the GAIN domain structure and detachment to physiological force ranges." @default.
- W4387608879 created "2023-10-14" @default.
- W4387608879 creator A5003456321 @default.
- W4387608879 creator A5028735839 @default.
- W4387608879 creator A5029928652 @default.
- W4387608879 creator A5037732408 @default.
- W4387608879 creator A5045209599 @default.
- W4387608879 creator A5057973936 @default.
- W4387608879 creator A5088582903 @default.
- W4387608879 creator A5088875441 @default.
- W4387608879 date "2023-10-13" @default.
- W4387608879 modified "2023-10-15" @default.
- W4387608879 title "Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs" @default.
- W4387608879 cites W1583577648 @default.
- W4387608879 cites W1919230608 @default.
- W4387608879 cites W1966354110 @default.
- W4387608879 cites W1974740818 @default.
- W4387608879 cites W1976672416 @default.
- W4387608879 cites W1977223822 @default.
- W4387608879 cites W1977789280 @default.
- W4387608879 cites W1979010452 @default.
- W4387608879 cites W1980022376 @default.
- W4387608879 cites W1995016025 @default.
- W4387608879 cites W2001508625 @default.
- W4387608879 cites W2010441615 @default.
- W4387608879 cites W2021218920 @default.
- W4387608879 cites W2028645925 @default.
- W4387608879 cites W2038489019 @default.
- W4387608879 cites W2051852715 @default.
- W4387608879 cites W2065744038 @default.
- W4387608879 cites W2111689719 @default.
- W4387608879 cites W2116194397 @default.
- W4387608879 cites W2159319913 @default.
- W4387608879 cites W2217674194 @default.
- W4387608879 cites W2257905227 @default.
- W4387608879 cites W2320612980 @default.
- W4387608879 cites W2468082290 @default.
- W4387608879 cites W2498296569 @default.
- W4387608879 cites W2522147339 @default.
- W4387608879 cites W2551801949 @default.
- W4387608879 cites W2553512748 @default.
- W4387608879 cites W2556881076 @default.
- W4387608879 cites W2588374458 @default.
- W4387608879 cites W2624758059 @default.
- W4387608879 cites W2675059502 @default.
- W4387608879 cites W2741379309 @default.
- W4387608879 cites W2741797758 @default.
- W4387608879 cites W2742439855 @default.
- W4387608879 cites W2777807685 @default.
- W4387608879 cites W2794429211 @default.
- W4387608879 cites W2805666212 @default.
- W4387608879 cites W2916366474 @default.
- W4387608879 cites W2922224975 @default.
- W4387608879 cites W2922236309 @default.
- W4387608879 cites W3024374631 @default.
- W4387608879 cites W3047702677 @default.
- W4387608879 cites W3093618641 @default.
- W4387608879 cites W3123876428 @default.
- W4387608879 cites W3160741511 @default.
- W4387608879 cites W4210998457 @default.
- W4387608879 cites W4223893037 @default.
- W4387608879 cites W4223902575 @default.
- W4387608879 cites W4223907742 @default.
- W4387608879 cites W4223978018 @default.
- W4387608879 cites W4229012588 @default.
- W4387608879 cites W4283326848 @default.
- W4387608879 cites W4293068210 @default.
- W4387608879 cites W4294991048 @default.
- W4387608879 cites W4296772794 @default.
- W4387608879 cites W4307656894 @default.
- W4387608879 cites W4318670265 @default.
- W4387608879 cites W4323543016 @default.
- W4387608879 cites W4387608899 @default.
- W4387608879 doi "https://doi.org/10.1021/acs.nanolett.3c01163" @default.
- W4387608879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37831892" @default.
- W4387608879 hasPublicationYear "2023" @default.
- W4387608879 type Work @default.
- W4387608879 citedByCount "0" @default.
- W4387608879 crossrefType "journal-article" @default.
- W4387608879 hasAuthorship W4387608879A5003456321 @default.
- W4387608879 hasAuthorship W4387608879A5028735839 @default.
- W4387608879 hasAuthorship W4387608879A5029928652 @default.
- W4387608879 hasAuthorship W4387608879A5037732408 @default.
- W4387608879 hasAuthorship W4387608879A5045209599 @default.
- W4387608879 hasAuthorship W4387608879A5057973936 @default.
- W4387608879 hasAuthorship W4387608879A5088582903 @default.
- W4387608879 hasAuthorship W4387608879A5088875441 @default.
- W4387608879 hasConcept C102931765 @default.
- W4387608879 hasConcept C12554922 @default.
- W4387608879 hasConcept C135285700 @default.
- W4387608879 hasConcept C147789679 @default.
- W4387608879 hasConcept C170493617 @default.
- W4387608879 hasConcept C171250308 @default.
- W4387608879 hasConcept C177502760 @default.
- W4387608879 hasConcept C185592680 @default.
- W4387608879 hasConcept C192562407 @default.
- W4387608879 hasConcept C194257627 @default.
- W4387608879 hasConcept C28406088 @default.
- W4387608879 hasConcept C4001165 @default.
- W4387608879 hasConcept C46362747 @default.