FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387609531> ?p ?o ?g. }

• W4387609531 abstract "Lung adenocarcinoma (LUAD) remains a leading cause of cancer-related morbidity and mortality globally. While DDX52, an ATP-dependent RNA helicase, plays a role in several biological processes, its specific involvement in LUAD is yet to be elucidated. We utilized ROC curves to determine DDX52's predictive potential for LUAD. Kaplan-Meier survival curves, along with univariate and multivariate Cox analyses, assessed the prognostic implications of DDX52 in LUAD. We constructed nomogram models to further delineate DDX52's influence on prognosis, employed GSEA for functional analysis, and used qRT-PCR to examine DDX52 expression in LUAD tissues. DDX52 expression was notably higher in LUAD tissues, suggesting its potential as a negative prognostic marker. We observed a direct relationship between DDX52 expression and advanced T and N stages, as well as higher grading and staging in LUAD patients. Cox analyses further underscored DDX52's role as an independent prognostic determinant for LUAD. GSEA insights indicated DDX52's influence on LUAD progression via multiple signaling pathways. Our nomogram, founded on DDX52 expression, effectively projected LUAD patient survival, as validated by calibration curves. Elevated DDX52 expression in LUAD tissues signals its potential as a poor prognostic marker. Our findings emphasize DDX52's role not only as an independent prognostic factor for LUAD but also as a significant influencer in its progression through diverse signaling pathways. The constructed nomogram also underscores the feasibility of predicting LUAD patient survival based on DDX52 expression." @default.
• W4387609531 created "2023-10-14" @default.
• W4387609531 creator A5000340730 @default.
• W4387609531 creator A5083467963 @default.
• W4387609531 date "2023-10-13" @default.
• W4387609531 modified "2023-10-18" @default.
• W4387609531 title "DDX52 gene expression in LUAD tissues indicates potential as a prognostic biomarker and therapeutic target" @default.
• W4387609531 cites W1994244319 @default.
• W4387609531 cites W2036071052 @default.
• W4387609531 cites W2039885485 @default.
• W4387609531 cites W2130410032 @default.
• W4387609531 cites W2134799983 @default.
• W4387609531 cites W2150964566 @default.
• W4387609531 cites W2158485828 @default.
• W4387609531 cites W2251438188 @default.
• W4387609531 cites W2352491315 @default.
• W4387609531 cites W2578197026 @default.
• W4387609531 cites W2593973360 @default.
• W4387609531 cites W2767255518 @default.
• W4387609531 cites W2776346029 @default.
• W4387609531 cites W2784371446 @default.
• W4387609531 cites W2976516489 @default.
• W4387609531 cites W2998610126 @default.
• W4387609531 cites W2999417355 @default.
• W4387609531 cites W3008728297 @default.
• W4387609531 cites W3028304854 @default.
• W4387609531 cites W3135105663 @default.
• W4387609531 cites W3139802259 @default.
• W4387609531 cites W3159180476 @default.
• W4387609531 cites W3178944585 @default.
• W4387609531 cites W3179065218 @default.
• W4387609531 cites W3193856798 @default.
• W4387609531 cites W3194929622 @default.
• W4387609531 cites W3197593329 @default.
• W4387609531 cites W4224096772 @default.
• W4387609531 cites W4226239794 @default.
• W4387609531 cites W4281729829 @default.
• W4387609531 cites W4283163824 @default.
• W4387609531 cites W4308723237 @default.
• W4387609531 cites W4315754639 @default.
• W4387609531 cites W4384558594 @default.
• W4387609531 cites W4385567155 @default.
• W4387609531 doi "https://doi.org/10.1038/s41598-023-44347-5" @default.
• W4387609531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37833424" @default.
• W4387609531 hasPublicationYear "2023" @default.
• W4387609531 type Work @default.
• W4387609531 citedByCount "0" @default.
• W4387609531 crossrefType "journal-article" @default.
• W4387609531 hasAuthorship W4387609531A5000340730 @default.
• W4387609531 hasAuthorship W4387609531A5083467963 @default.
• W4387609531 hasBestOaLocation W43876095311 @default.
• W4387609531 hasConcept C10515644 @default.
• W4387609531 hasConcept C105795698 @default.
• W4387609531 hasConcept C121608353 @default.
• W4387609531 hasConcept C126322002 @default.
• W4387609531 hasConcept C143998085 @default.
• W4387609531 hasConcept C161584116 @default.
• W4387609531 hasConcept C199163554 @default.
• W4387609531 hasConcept C2781182431 @default.
• W4387609531 hasConcept C2781197716 @default.
• W4387609531 hasConcept C33923547 @default.
• W4387609531 hasConcept C34626388 @default.
• W4387609531 hasConcept C502942594 @default.
• W4387609531 hasConcept C50382708 @default.
• W4387609531 hasConcept C54355233 @default.
• W4387609531 hasConcept C71924100 @default.
• W4387609531 hasConcept C86803240 @default.
• W4387609531 hasConceptScore W4387609531C10515644 @default.
• W4387609531 hasConceptScore W4387609531C105795698 @default.
• W4387609531 hasConceptScore W4387609531C121608353 @default.
• W4387609531 hasConceptScore W4387609531C126322002 @default.
• W4387609531 hasConceptScore W4387609531C143998085 @default.
• W4387609531 hasConceptScore W4387609531C161584116 @default.
• W4387609531 hasConceptScore W4387609531C199163554 @default.
• W4387609531 hasConceptScore W4387609531C2781182431 @default.
• W4387609531 hasConceptScore W4387609531C2781197716 @default.
• W4387609531 hasConceptScore W4387609531C33923547 @default.
• W4387609531 hasConceptScore W4387609531C34626388 @default.
• W4387609531 hasConceptScore W4387609531C502942594 @default.
• W4387609531 hasConceptScore W4387609531C50382708 @default.
• W4387609531 hasConceptScore W4387609531C54355233 @default.
• W4387609531 hasConceptScore W4387609531C71924100 @default.
• W4387609531 hasConceptScore W4387609531C86803240 @default.
• W4387609531 hasIssue "1" @default.
• W4387609531 hasLocation W43876095311 @default.
• W4387609531 hasLocation W43876095312 @default.
• W4387609531 hasOpenAccess W4387609531 @default.
• W4387609531 hasPrimaryLocation W43876095311 @default.
• W4387609531 hasRelatedWork W1970018641 @default.
• W4387609531 hasRelatedWork W1993821226 @default.
• W4387609531 hasRelatedWork W1999313618 @default.
• W4387609531 hasRelatedWork W2004029742 @default.
• W4387609531 hasRelatedWork W2063908487 @default.
• W4387609531 hasRelatedWork W2089138782 @default.
• W4387609531 hasRelatedWork W2409329088 @default.
• W4387609531 hasRelatedWork W2806270659 @default.
• W4387609531 hasRelatedWork W4226494765 @default.
• W4387609531 hasRelatedWork W4233588653 @default.
• W4387609531 hasVolume "13" @default.
• W4387609531 isParatext "false" @default.

• next