Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387611145> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W4387611145 abstract "Imeglimin is a novel antidiabetic drug structurally related to metformin. Metformin has been shown to modulate the circadian clock in rat fibroblasts. Accordingly, in the present study, we aimed to determine whether imeglimin can impact the circadian oscillator in mouse embryonic fibroblasts (MEFs). MEFs carrying a Bmal1-Emerald luciferase (Bmal1-ELuc) reporter were exposed to imeglimin (0.1 or 1 mM), metformin (0.1 or 1 mM), a nicotinamide phosphoribosyltransferase inhibitor FK866, and/or vehicle. Subsequently, Bmal1-ELuc expression and clock gene mRNA expression levels were measured at 10-min intervals for 55 h and 4-h intervals for 32 h, respectively. Imeglimin significantly prolonged the period (from 26.3 to 30.0 h at 0.1 mM) and dose-dependently increased the amplitude (9.6-fold at 1 mM) of the Bmal1-ELuc expression rhythm; however, metformin exhibited minimal effects on these parameters. Moreover, imeglimin notably impacted the rhythmic mRNA expression of clock genes (Bmal1, Per1, and Cry1). The concurrent addition of FK866 partly inhibited the effects of imeglimin on both Bmal1-ELuc expression and clock gene mRNA expression. Conclusion: Collectively, these results reveal that imeglimin profoundly affects the circadian clock in MEFs. Further studies are needed to evaluate whether imeglimin treatment could exert similar effects in vivo." @default.
- W4387611145 created "2023-10-14" @default.
- W4387611145 creator A5001307095 @default.
- W4387611145 creator A5002913131 @default.
- W4387611145 creator A5005296918 @default.
- W4387611145 creator A5017952469 @default.
- W4387611145 creator A5024873634 @default.
- W4387611145 creator A5027315797 @default.
- W4387611145 creator A5034101987 @default.
- W4387611145 creator A5036757365 @default.
- W4387611145 creator A5043465349 @default.
- W4387611145 creator A5052925737 @default.
- W4387611145 creator A5057336195 @default.
- W4387611145 creator A5061971295 @default.
- W4387611145 creator A5062738101 @default.
- W4387611145 creator A5072175595 @default.
- W4387611145 creator A5076023653 @default.
- W4387611145 date "2023-10-01" @default.
- W4387611145 modified "2023-10-14" @default.
- W4387611145 title "Imeglimin profoundly affects the circadian clock in mouse embryonic fibroblasts" @default.
- W4387611145 doi "https://doi.org/10.1016/j.jphs.2023.10.001" @default.
- W4387611145 hasPublicationYear "2023" @default.
- W4387611145 type Work @default.
- W4387611145 citedByCount "0" @default.
- W4387611145 crossrefType "journal-article" @default.
- W4387611145 hasAuthorship W4387611145A5001307095 @default.
- W4387611145 hasAuthorship W4387611145A5002913131 @default.
- W4387611145 hasAuthorship W4387611145A5005296918 @default.
- W4387611145 hasAuthorship W4387611145A5017952469 @default.
- W4387611145 hasAuthorship W4387611145A5024873634 @default.
- W4387611145 hasAuthorship W4387611145A5027315797 @default.
- W4387611145 hasAuthorship W4387611145A5034101987 @default.
- W4387611145 hasAuthorship W4387611145A5036757365 @default.
- W4387611145 hasAuthorship W4387611145A5043465349 @default.
- W4387611145 hasAuthorship W4387611145A5052925737 @default.
- W4387611145 hasAuthorship W4387611145A5057336195 @default.
- W4387611145 hasAuthorship W4387611145A5061971295 @default.
- W4387611145 hasAuthorship W4387611145A5062738101 @default.
- W4387611145 hasAuthorship W4387611145A5072175595 @default.
- W4387611145 hasAuthorship W4387611145A5076023653 @default.
- W4387611145 hasBestOaLocation W43876111451 @default.
- W4387611145 hasConcept C104317684 @default.
- W4387611145 hasConcept C121446783 @default.
- W4387611145 hasConcept C126322002 @default.
- W4387611145 hasConcept C134018914 @default.
- W4387611145 hasConcept C145103041 @default.
- W4387611145 hasConcept C150194340 @default.
- W4387611145 hasConcept C184738001 @default.
- W4387611145 hasConcept C2780360009 @default.
- W4387611145 hasConcept C38606739 @default.
- W4387611145 hasConcept C54355233 @default.
- W4387611145 hasConcept C71924100 @default.
- W4387611145 hasConcept C86803240 @default.
- W4387611145 hasConcept C95444343 @default.
- W4387611145 hasConceptScore W4387611145C104317684 @default.
- W4387611145 hasConceptScore W4387611145C121446783 @default.
- W4387611145 hasConceptScore W4387611145C126322002 @default.
- W4387611145 hasConceptScore W4387611145C134018914 @default.
- W4387611145 hasConceptScore W4387611145C145103041 @default.
- W4387611145 hasConceptScore W4387611145C150194340 @default.
- W4387611145 hasConceptScore W4387611145C184738001 @default.
- W4387611145 hasConceptScore W4387611145C2780360009 @default.
- W4387611145 hasConceptScore W4387611145C38606739 @default.
- W4387611145 hasConceptScore W4387611145C54355233 @default.
- W4387611145 hasConceptScore W4387611145C71924100 @default.
- W4387611145 hasConceptScore W4387611145C86803240 @default.
- W4387611145 hasConceptScore W4387611145C95444343 @default.
- W4387611145 hasLocation W43876111451 @default.
- W4387611145 hasOpenAccess W4387611145 @default.
- W4387611145 hasPrimaryLocation W43876111451 @default.
- W4387611145 hasRelatedWork W1966595619 @default.
- W4387611145 hasRelatedWork W1970711394 @default.
- W4387611145 hasRelatedWork W1973760267 @default.
- W4387611145 hasRelatedWork W2067119265 @default.
- W4387611145 hasRelatedWork W2076640453 @default.
- W4387611145 hasRelatedWork W2105185711 @default.
- W4387611145 hasRelatedWork W2135658843 @default.
- W4387611145 hasRelatedWork W2150892098 @default.
- W4387611145 hasRelatedWork W3022220350 @default.
- W4387611145 hasRelatedWork W4378649417 @default.
- W4387611145 isParatext "false" @default.
- W4387611145 isRetracted "false" @default.
- W4387611145 workType "article" @default.