Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387611164> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W4387611164 endingPage "106999" @default.
- W4387611164 startingPage "106999" @default.
- W4387611164 abstract "Data about antituberculosis drugs binding are incomplete for first-line drugs and lacking for second-line drugs that are used extensively for multi-drug resistant tuberculosis (levofloxacin, linezolid and moxifloxacin). Thus, the main purposes of this study were first to investigate thoroughly the relation between the carrier-proteins level and the drug binding and second to investigate the feasibility of predicting the free drug concentrations by the means of in vitro and in vivo results. In vitro experiments mimicked real-case samples by spiking drugs combinations from the clinical practice. We measured a median in vivo protein binding of 1.5% for ethambutol, 9.7% for isoniazid, 0.7% for pyrazinamide and 88.2% for rifampicin; and a median in vitro protein binding of 26.2% for levofloxacin, 12.8% for linezolid and 46.3% for moxifloxacin. The albumin concentration had a moderate impact on the moxifloxacin binding and a strong impact on the levofloxacin, linezolid and rifampicin binding (below values of 30 g/L). The determination of the free drug concentration seems to have few interests for ethambutol, isoniazid, moxifloxacin and pyrazinamide, a limited interest for linezolid because of its low binding and a major interest for rifampicin in hypoalbuminemia TB patients and for levofloxacin because their total concentration was an inaccurate reflection of the free concentration. The free concentration predicted by mathematical model was suitable for levofloxacin and linezolid, unlike for rifampicin, where the real free concentration should be measured. Further investigations should be carried out to investigate the benefit of the free concentration for levofloxacin, linezolid and rifampicin mainly in the critical period of active tuberculosis associated to hypoalbuminemia." @default.
- W4387611164 created "2023-10-14" @default.
- W4387611164 creator A5066259134 @default.
- W4387611164 creator A5075228524 @default.
- W4387611164 creator A5093057649 @default.
- W4387611164 date "2023-10-01" @default.
- W4387611164 modified "2023-10-16" @default.
- W4387611164 title "Protein binding investigation of first-line and second-line antituberculosis drugs" @default.
- W4387611164 doi "https://doi.org/10.1016/j.ijantimicag.2023.106999" @default.
- W4387611164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37838149" @default.
- W4387611164 hasPublicationYear "2023" @default.
- W4387611164 type Work @default.
- W4387611164 citedByCount "0" @default.
- W4387611164 crossrefType "journal-article" @default.
- W4387611164 hasAuthorship W4387611164A5066259134 @default.
- W4387611164 hasAuthorship W4387611164A5075228524 @default.
- W4387611164 hasAuthorship W4387611164A5093057649 @default.
- W4387611164 hasConcept C142724271 @default.
- W4387611164 hasConcept C150903083 @default.
- W4387611164 hasConcept C185592680 @default.
- W4387611164 hasConcept C207001950 @default.
- W4387611164 hasConcept C2776228421 @default.
- W4387611164 hasConcept C2776967927 @default.
- W4387611164 hasConcept C2778607973 @default.
- W4387611164 hasConcept C2778836808 @default.
- W4387611164 hasConcept C2778980435 @default.
- W4387611164 hasConcept C2779489039 @default.
- W4387611164 hasConcept C2780459521 @default.
- W4387611164 hasConcept C2781069245 @default.
- W4387611164 hasConcept C2781276175 @default.
- W4387611164 hasConcept C2781414143 @default.
- W4387611164 hasConcept C3019249092 @default.
- W4387611164 hasConcept C501593827 @default.
- W4387611164 hasConcept C523546767 @default.
- W4387611164 hasConcept C54355233 @default.
- W4387611164 hasConcept C55493867 @default.
- W4387611164 hasConcept C71924100 @default.
- W4387611164 hasConcept C86803240 @default.
- W4387611164 hasConcept C98274493 @default.
- W4387611164 hasConceptScore W4387611164C142724271 @default.
- W4387611164 hasConceptScore W4387611164C150903083 @default.
- W4387611164 hasConceptScore W4387611164C185592680 @default.
- W4387611164 hasConceptScore W4387611164C207001950 @default.
- W4387611164 hasConceptScore W4387611164C2776228421 @default.
- W4387611164 hasConceptScore W4387611164C2776967927 @default.
- W4387611164 hasConceptScore W4387611164C2778607973 @default.
- W4387611164 hasConceptScore W4387611164C2778836808 @default.
- W4387611164 hasConceptScore W4387611164C2778980435 @default.
- W4387611164 hasConceptScore W4387611164C2779489039 @default.
- W4387611164 hasConceptScore W4387611164C2780459521 @default.
- W4387611164 hasConceptScore W4387611164C2781069245 @default.
- W4387611164 hasConceptScore W4387611164C2781276175 @default.
- W4387611164 hasConceptScore W4387611164C2781414143 @default.
- W4387611164 hasConceptScore W4387611164C3019249092 @default.
- W4387611164 hasConceptScore W4387611164C501593827 @default.
- W4387611164 hasConceptScore W4387611164C523546767 @default.
- W4387611164 hasConceptScore W4387611164C54355233 @default.
- W4387611164 hasConceptScore W4387611164C55493867 @default.
- W4387611164 hasConceptScore W4387611164C71924100 @default.
- W4387611164 hasConceptScore W4387611164C86803240 @default.
- W4387611164 hasConceptScore W4387611164C98274493 @default.
- W4387611164 hasLocation W43876111641 @default.
- W4387611164 hasLocation W43876111642 @default.
- W4387611164 hasOpenAccess W4387611164 @default.
- W4387611164 hasPrimaryLocation W43876111641 @default.
- W4387611164 hasRelatedWork W1973586260 @default.
- W4387611164 hasRelatedWork W2001870329 @default.
- W4387611164 hasRelatedWork W2106810092 @default.
- W4387611164 hasRelatedWork W2140777369 @default.
- W4387611164 hasRelatedWork W2160753277 @default.
- W4387611164 hasRelatedWork W2229268890 @default.
- W4387611164 hasRelatedWork W2255884538 @default.
- W4387611164 hasRelatedWork W2394436392 @default.
- W4387611164 hasRelatedWork W2802877139 @default.
- W4387611164 hasRelatedWork W2979351381 @default.
- W4387611164 isParatext "false" @default.
- W4387611164 isRetracted "false" @default.
- W4387611164 workType "article" @default.