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- W4387611212 abstract "With every success comes a new challenge. Median survival for recipients of a heart transplantation (HT) during their pre-school years exceeds 20 years in the International Society of Heart and Lung Transplantation (ISHLT) Thoracic Registry, and most young pediatric recipients now survive into adulthood. 1 Singh T.P. Hsich E. Cherikh W.S. et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics. J Heart Lung Transplant. 2020; 39 (Oct): 1028-1037https://doi.org/10.1016/j.healun.2020.07.008 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar Despite these remarkable successes, significant longer-term potential for allograft dysfunction and allograft loss remains. Cardiac allograft vasculopathy (CAV) is a leading threat to allograft stability, and is associated with decreased survival and increased likelihood of re-transplantation. 2 Khush K.K. Hsich E. Potena L. et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-eighth adult heart transplantation report - 2021; Focus on recipient characteristics. J Heart Lung Transplant. 2021; 40 (Oct): 1035-1049https://doi.org/10.1016/j.healun.2021.07.015 Abstract Full Text Full Text PDF PubMed Scopus (92) Google Scholar Amongst pediatric HT recipients, those transplanted as infants have the lowest rates of CAV, 3 Rossano J.W. Cherikh W.S. Chambers D.C. et al. The Registry of the International Society for Heart and Lung Transplantation: Twentieth Pediatric Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time. J Heart Lung Transplant. 2017; 36 (Oct): 1060-1069https://doi.org/10.1016/j.healun.2017.07.018 Abstract Full Text Full Text PDF PubMed Scopus (90) Google Scholar probably due to immune system immaturity at transplantation and developmental differences in dyslipidemia and obesity prior to puberty when the prevalence of CAV approaches 20%; 4 Bogle C. Cantor R. Koehl D. et al. Obesity and dyslipidemia predict cardiac allograft vasculopathy and graft loss in children and adolescents post-heart transplant: A PHTS multi-institutional analysis. Pediatr Transplant. 2022; (Feb 5)e14244https://doi.org/10.1111/petr.14244 Crossref Scopus (2) Google Scholar conversely, those transplanted as teenagers have the highest rates of CAV with an anticipated prevalence around 50% at 10 years post-HT. 1 Singh T.P. Hsich E. Cherikh W.S. et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: 23rd pediatric heart transplantation report-2020; focus on deceased donor characteristics. J Heart Lung Transplant. 2020; 39 (Oct): 1028-1037https://doi.org/10.1016/j.healun.2020.07.008 Abstract Full Text Full Text PDF PubMed Scopus (20) Google Scholar" @default.
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- W4387611212 date "2023-10-01" @default.
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- W4387611212 title "Detecting and Managing Cardiac Allograft Vasculopathy Within the Transition from Pediatric to Adult Heart Transplantation Care: Lighting the Pathway Ahead" @default.
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- W4387611212 doi "https://doi.org/10.1016/j.healun.2023.10.008" @default.
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