Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387611221> ?p ?o ?g. }
- W4387611221 abstract "Oxidative stress is integral in the development of atherosclerosis, but knowledge of how oxidative stress affects atherosclerosis remains insufficient. Here, we design a multiplexed diagnostic tool that includes two functions (photoacoustic imaging and urinalysis), for assessing intraplaque and urinary malondialdehyde (MDA), a well-recognized end-product of oxidative stress. Molecular design is conducted to develop the first near-infrared MDA-responsive molecule (MRM). Acid-unlocked ratiometric photoacoustic nanoprobe is designed to report intraplaque MDA, enabling it to reflect plaque burden. Furthermore, MRM is tailored for urinary MDA detection with excellent specificity in a blind study. Moreover, we found a significant difference in urinary MDA between healthy adults and atherosclerotic patients (more than 600 participants). Combining these two functions, such a multiplexed diagnostic tool can dynamically report intraplaque and systemic oxidative stress levels during atherosclerosis progression, pneumonia infection, and drug treatment in atherosclerotic mice, which is promising for the auxiliary diagnosis of atherosclerosis." @default.
- W4387611221 created "2023-10-14" @default.
- W4387611221 creator A5008465754 @default.
- W4387611221 creator A5009074414 @default.
- W4387611221 creator A5016425958 @default.
- W4387611221 creator A5022198024 @default.
- W4387611221 creator A5022468747 @default.
- W4387611221 creator A5032346871 @default.
- W4387611221 creator A5032997576 @default.
- W4387611221 creator A5039414614 @default.
- W4387611221 creator A5051070109 @default.
- W4387611221 creator A5060378216 @default.
- W4387611221 creator A5061752926 @default.
- W4387611221 creator A5072979414 @default.
- W4387611221 creator A5073526202 @default.
- W4387611221 date "2023-10-13" @default.
- W4387611221 modified "2023-10-18" @default.
- W4387611221 title "Oxidative stress biomarker triggered multiplexed tool for auxiliary diagnosis of atherosclerosis" @default.
- W4387611221 cites W1544314093 @default.
- W4387611221 cites W1977756163 @default.
- W4387611221 cites W1994603950 @default.
- W4387611221 cites W2036361783 @default.
- W4387611221 cites W2043798557 @default.
- W4387611221 cites W2050402435 @default.
- W4387611221 cites W2083416749 @default.
- W4387611221 cites W2088005397 @default.
- W4387611221 cites W2117737656 @default.
- W4387611221 cites W2120332364 @default.
- W4387611221 cites W2123251003 @default.
- W4387611221 cites W2131894828 @default.
- W4387611221 cites W2148413446 @default.
- W4387611221 cites W2254568118 @default.
- W4387611221 cites W2274688339 @default.
- W4387611221 cites W2339190262 @default.
- W4387611221 cites W2344341837 @default.
- W4387611221 cites W2468517437 @default.
- W4387611221 cites W2484448248 @default.
- W4387611221 cites W2538132594 @default.
- W4387611221 cites W2559774257 @default.
- W4387611221 cites W2565209260 @default.
- W4387611221 cites W2587769401 @default.
- W4387611221 cites W2598796803 @default.
- W4387611221 cites W2725312479 @default.
- W4387611221 cites W2734521980 @default.
- W4387611221 cites W2734558695 @default.
- W4387611221 cites W2735126824 @default.
- W4387611221 cites W2762786091 @default.
- W4387611221 cites W2809362553 @default.
- W4387611221 cites W2888992202 @default.
- W4387611221 cites W2896814589 @default.
- W4387611221 cites W2904257675 @default.
- W4387611221 cites W2965605561 @default.
- W4387611221 cites W2971937087 @default.
- W4387611221 cites W2977696708 @default.
- W4387611221 cites W3000044049 @default.
- W4387611221 cites W3005894953 @default.
- W4387611221 cites W3016030808 @default.
- W4387611221 cites W3045107785 @default.
- W4387611221 cites W3049524872 @default.
- W4387611221 cites W3105919133 @default.
- W4387611221 cites W3108954468 @default.
- W4387611221 cites W3155824129 @default.
- W4387611221 cites W3160645868 @default.
- W4387611221 cites W3162020708 @default.
- W4387611221 cites W3173948537 @default.
- W4387611221 cites W3211159986 @default.
- W4387611221 cites W4200141674 @default.
- W4387611221 cites W4211134725 @default.
- W4387611221 cites W4214808332 @default.
- W4387611221 cites W4214880008 @default.
- W4387611221 cites W4221008773 @default.
- W4387611221 cites W4225287557 @default.
- W4387611221 cites W4282032657 @default.
- W4387611221 cites W4318755116 @default.
- W4387611221 cites W4385477410 @default.
- W4387611221 doi "https://doi.org/10.1126/sciadv.adh1037" @default.
- W4387611221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37831761" @default.
- W4387611221 hasPublicationYear "2023" @default.
- W4387611221 type Work @default.
- W4387611221 citedByCount "0" @default.
- W4387611221 crossrefType "journal-article" @default.
- W4387611221 hasAuthorship W4387611221A5008465754 @default.
- W4387611221 hasAuthorship W4387611221A5009074414 @default.
- W4387611221 hasAuthorship W4387611221A5016425958 @default.
- W4387611221 hasAuthorship W4387611221A5022198024 @default.
- W4387611221 hasAuthorship W4387611221A5022468747 @default.
- W4387611221 hasAuthorship W4387611221A5032346871 @default.
- W4387611221 hasAuthorship W4387611221A5032997576 @default.
- W4387611221 hasAuthorship W4387611221A5039414614 @default.
- W4387611221 hasAuthorship W4387611221A5051070109 @default.
- W4387611221 hasAuthorship W4387611221A5060378216 @default.
- W4387611221 hasAuthorship W4387611221A5061752926 @default.
- W4387611221 hasAuthorship W4387611221A5072979414 @default.
- W4387611221 hasAuthorship W4387611221A5073526202 @default.
- W4387611221 hasBestOaLocation W43876112211 @default.
- W4387611221 hasConcept C120665830 @default.
- W4387611221 hasConcept C121332964 @default.
- W4387611221 hasConcept C126322002 @default.
- W4387611221 hasConcept C142724271 @default.
- W4387611221 hasConcept C185592680 @default.