Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387611298> ?p ?o ?g. }
- W4387611298 abstract "Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are causing significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly emerging or re-emerging viral infections, specifically dengue virus (DENV), are known to occur annually. Because no virus-specific and fully effective treatments against these or many other viruses have been approved, there is an urgent need for novel, effective therapeutic agents. Here, we identified 2-thiouridine (s2U) as a broad-spectrum antiviral ribonucleoside analogue that exhibited antiviral activity against several positive-sense single-stranded RNA (ssRNA+) viruses, such as DENV, SARS-CoV-2, and its variants of concern, including the currently circulating Omicron subvariants. s2U inhibits RNA synthesis catalyzed by viral RNA-dependent RNA polymerase, thereby reducing viral RNA replication, which improved the survival rate of mice infected with DENV2 or SARS-CoV-2 in our animal models. Our findings demonstrate that s2U is a potential broad-spectrum antiviral agent not only against DENV and SARS-CoV-2 but other ssRNA+ viruses." @default.
- W4387611298 created "2023-10-14" @default.
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- W4387611298 date "2023-10-13" @default.
- W4387611298 modified "2023-10-15" @default.
- W4387611298 title "2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses" @default.
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- W4387611298 doi "https://doi.org/10.1073/pnas.2304139120" @default.
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