Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387612997> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W4387612997 abstract "Abstract Background Inclusion in the WHO’s first Fungal Priority Pathogens List under ‘high priority’ fungal species, highlights the need for robust surveillance of Histoplasma species. in endemic and underrepresented regions. Despite increasing reports of histoplasmosis in Africa, data on the burden of this fungal disease are sparse in The Gambia. This baseline study examined the human seroprevalence of anti-Histoplasma antibody in a TB patient group in The Gambia, explored associations between seropositivity and demographic and clinical variables, and proposed future research directions. Methods Biobanked plasma samples were selected from active TB cases with variable HIV infection status. Latex agglutination tests were performed on samples from 52 study participants to detect the presence of anti-Histoplasma antibodies. Potential risk factors for Histoplasma exposure were explored using logistic regression analysis. Results The sample seroprevalence of anti-Histoplasma antibody was 28.8% (n=15/52, 95% Confidence Interval (CI) 17.1-43.1%). Multivariable logistic regression analysis identified a statistically significant association between Histoplasma seropositivity and age (OR=0.91 95% CI 0.84-0.98, p=0.008). Conclusions This baseline study provides evidence of Histoplasma seropositivity in TB patients in The Gambia and explores risk factors for exposure. The small sample size and use of the LAT in TB and HIV-positive patient groups are significant study limitations. Future research directions are proposed to ascertain the burden of Histoplasma in general and patient populations and explore the context-specific risk factors for exposure and infection in The Gambia." @default.
- W4387612997 created "2023-10-14" @default.
- W4387612997 creator A5018969845 @default.
- W4387612997 creator A5032114701 @default.
- W4387612997 creator A5037789356 @default.
- W4387612997 creator A5039929540 @default.
- W4387612997 creator A5046938517 @default.
- W4387612997 creator A5065441409 @default.
- W4387612997 creator A5070472226 @default.
- W4387612997 date "2023-10-13" @default.
- W4387612997 modified "2023-10-15" @default.
- W4387612997 title "<i>Histoplasma</i> seropositivity in TB patients in The Gambia: Evidence to drive research on a high priority fungal pathogen" @default.
- W4387612997 doi "https://doi.org/10.1093/ofid/ofad510" @default.
- W4387612997 hasPublicationYear "2023" @default.
- W4387612997 type Work @default.
- W4387612997 citedByCount "0" @default.
- W4387612997 crossrefType "journal-article" @default.
- W4387612997 hasAuthorship W4387612997A5018969845 @default.
- W4387612997 hasAuthorship W4387612997A5032114701 @default.
- W4387612997 hasAuthorship W4387612997A5037789356 @default.
- W4387612997 hasAuthorship W4387612997A5039929540 @default.
- W4387612997 hasAuthorship W4387612997A5046938517 @default.
- W4387612997 hasAuthorship W4387612997A5065441409 @default.
- W4387612997 hasAuthorship W4387612997A5070472226 @default.
- W4387612997 hasBestOaLocation W43876129971 @default.
- W4387612997 hasConcept C126322002 @default.
- W4387612997 hasConcept C151730666 @default.
- W4387612997 hasConcept C151956035 @default.
- W4387612997 hasConcept C159654299 @default.
- W4387612997 hasConcept C203014093 @default.
- W4387612997 hasConcept C2777802930 @default.
- W4387612997 hasConcept C2778494684 @default.
- W4387612997 hasConcept C2778803964 @default.
- W4387612997 hasConcept C2779343474 @default.
- W4387612997 hasConcept C2780318139 @default.
- W4387612997 hasConcept C44249647 @default.
- W4387612997 hasConcept C45189115 @default.
- W4387612997 hasConcept C71924100 @default.
- W4387612997 hasConcept C86803240 @default.
- W4387612997 hasConceptScore W4387612997C126322002 @default.
- W4387612997 hasConceptScore W4387612997C151730666 @default.
- W4387612997 hasConceptScore W4387612997C151956035 @default.
- W4387612997 hasConceptScore W4387612997C159654299 @default.
- W4387612997 hasConceptScore W4387612997C203014093 @default.
- W4387612997 hasConceptScore W4387612997C2777802930 @default.
- W4387612997 hasConceptScore W4387612997C2778494684 @default.
- W4387612997 hasConceptScore W4387612997C2778803964 @default.
- W4387612997 hasConceptScore W4387612997C2779343474 @default.
- W4387612997 hasConceptScore W4387612997C2780318139 @default.
- W4387612997 hasConceptScore W4387612997C44249647 @default.
- W4387612997 hasConceptScore W4387612997C45189115 @default.
- W4387612997 hasConceptScore W4387612997C71924100 @default.
- W4387612997 hasConceptScore W4387612997C86803240 @default.
- W4387612997 hasLocation W43876129971 @default.
- W4387612997 hasOpenAccess W4387612997 @default.
- W4387612997 hasPrimaryLocation W43876129971 @default.
- W4387612997 hasRelatedWork W2016667107 @default.
- W4387612997 hasRelatedWork W2045133204 @default.
- W4387612997 hasRelatedWork W2163874812 @default.
- W4387612997 hasRelatedWork W2391104710 @default.
- W4387612997 hasRelatedWork W2417227149 @default.
- W4387612997 hasRelatedWork W2954261318 @default.
- W4387612997 hasRelatedWork W3001164210 @default.
- W4387612997 hasRelatedWork W3021354514 @default.
- W4387612997 hasRelatedWork W4307427392 @default.
- W4387612997 hasRelatedWork W4385833712 @default.
- W4387612997 isParatext "false" @default.
- W4387612997 isRetracted "false" @default.
- W4387612997 workType "article" @default.