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- W4387613681 endingPage "103799" @default.
- W4387613681 startingPage "103799" @default.
- W4387613681 abstract "The reactive functionalities of drugs that engage in covalent interactions with the enzyme/receptor residue in either a reversible or an irreversible manner are called 'warheads'. Covalent warheads that were previously neglected because of safety concerns have recently gained center stage as a result of their various advantages over noncovalent drugs, including increased selectivity, increased residence time, and higher potency. With the approval of several covalent inhibitors over the past decade, research in this area has accelerated. Various strategies are being continuously developed to tune the characteristics of warheads to improve their potency and mitigate toxicity. Here, we review research progress in warhead discovery over the past 5 years to provide valuable insights for future drug discovery." @default.
- W4387613681 created "2023-10-14" @default.
- W4387613681 creator A5057123892 @default.
- W4387613681 creator A5084633735 @default.
- W4387613681 date "2023-10-01" @default.
- W4387613681 modified "2023-10-17" @default.
- W4387613681 title "The expanding repertoire of covalent warheads for drug discovery" @default.
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