Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387614032> ?p ?o ?g. }
- W4387614032 endingPage "16" @default.
- W4387614032 startingPage "1" @default.
- W4387614032 abstract "Assessments of Alzheimer's disease pathology do not routinely include lower brainstem, olfactory bulb, and spinal cord.Test if amyloid-β (Aβ) and paired helical filament (PHF) tau-tangles outside the cerebrum are associated with the odds of dementia.Autopsies were obtained in decedents with cognitive testing (n = 300). Aβ plaques and PHF tau-tangles were assessed in 24 sites: cerebrum (n = 14), brainstem (n = 5), olfactory bulb, and four spinal cord levels. Since spinal Aβ were absent in the first 165 cases, it was not assessed in the remaining cases.Age at death was 91 years old. About 90% had Aβ in cerebrum and of these, half had Aβ in the brainstem. Of the latter, 85% showed Aβ in the olfactory bulb. All but one participant had tau-tangles in the cerebrum and 86% had brainstem tau-tangles. Of the latter, 80% had tau-tangles in olfactory bulb and 36% tau-tangles in one or more spinal cord levels. About 90% of adults with tau-tangles also had Aβ in one or more regions. In a logistic model controlling for demographics, Aβ and tau-tangles within the cerebrum, the presence of Aβ in olfactory bulb [OR, 1.74(1.00, 3.05)]; tau-tangles in brainstem [OR, 4.00(1.1.57,10.21)]; and spinal cord [OR, 1.87 (1.21,3.11)] were independently associated with higher odds of dementia.Regional differences in Aβ and tau-tangle accumulation extend beyond cerebrum to spinal cord and their presence outside the cerebrum are associated with a higher odds of dementia. Further studies are needed to clarify the extent, burden, and consequences of AD pathology outside of cerebrum." @default.
- W4387614032 created "2023-10-14" @default.
- W4387614032 creator A5007574006 @default.
- W4387614032 creator A5011964819 @default.
- W4387614032 creator A5014075642 @default.
- W4387614032 creator A5015535104 @default.
- W4387614032 creator A5020237298 @default.
- W4387614032 creator A5020374459 @default.
- W4387614032 creator A5057687099 @default.
- W4387614032 creator A5070294274 @default.
- W4387614032 creator A5082948468 @default.
- W4387614032 date "2023-10-09" @default.
- W4387614032 modified "2023-10-17" @default.
- W4387614032 title "Alzheimer’s Disease Pathology Outside of the Cerebrum Is Related to a Higher Odds of Dementia" @default.
- W4387614032 cites W1769834772 @default.
- W4387614032 cites W1915842929 @default.
- W4387614032 cites W1931372835 @default.
- W4387614032 cites W1967823816 @default.
- W4387614032 cites W1971032265 @default.
- W4387614032 cites W1976452134 @default.
- W4387614032 cites W1985747467 @default.
- W4387614032 cites W1993023011 @default.
- W4387614032 cites W2034030646 @default.
- W4387614032 cites W2036736258 @default.
- W4387614032 cites W2037357237 @default.
- W4387614032 cites W2039900537 @default.
- W4387614032 cites W2052742260 @default.
- W4387614032 cites W2075576303 @default.
- W4387614032 cites W2113205299 @default.
- W4387614032 cites W2115017507 @default.
- W4387614032 cites W2128228199 @default.
- W4387614032 cites W2129181278 @default.
- W4387614032 cites W2132740963 @default.
- W4387614032 cites W2135771073 @default.
- W4387614032 cites W2143461767 @default.
- W4387614032 cites W2148230634 @default.
- W4387614032 cites W2195527239 @default.
- W4387614032 cites W2432513713 @default.
- W4387614032 cites W2574723258 @default.
- W4387614032 cites W2581791236 @default.
- W4387614032 cites W2755035583 @default.
- W4387614032 cites W2756913555 @default.
- W4387614032 cites W2777276375 @default.
- W4387614032 cites W2809330972 @default.
- W4387614032 cites W2884590574 @default.
- W4387614032 cites W2918857132 @default.
- W4387614032 cites W2940298618 @default.
- W4387614032 cites W2952615074 @default.
- W4387614032 cites W2961385929 @default.
- W4387614032 cites W3019122005 @default.
- W4387614032 cites W3019351245 @default.
- W4387614032 cites W3023013291 @default.
- W4387614032 cites W3039911636 @default.
- W4387614032 cites W3042582463 @default.
- W4387614032 cites W3046504080 @default.
- W4387614032 cites W3082281252 @default.
- W4387614032 cites W3095639822 @default.
- W4387614032 cites W3120838629 @default.
- W4387614032 cites W4225153522 @default.
- W4387614032 cites W4238843899 @default.
- W4387614032 cites W4282917955 @default.
- W4387614032 doi "https://doi.org/10.3233/jad-230223" @default.
- W4387614032 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37840485" @default.
- W4387614032 hasPublicationYear "2023" @default.
- W4387614032 type Work @default.
- W4387614032 citedByCount "0" @default.
- W4387614032 crossrefType "journal-article" @default.
- W4387614032 hasAuthorship W4387614032A5007574006 @default.
- W4387614032 hasAuthorship W4387614032A5011964819 @default.
- W4387614032 hasAuthorship W4387614032A5014075642 @default.
- W4387614032 hasAuthorship W4387614032A5015535104 @default.
- W4387614032 hasAuthorship W4387614032A5020237298 @default.
- W4387614032 hasAuthorship W4387614032A5020374459 @default.
- W4387614032 hasAuthorship W4387614032A5057687099 @default.
- W4387614032 hasAuthorship W4387614032A5070294274 @default.
- W4387614032 hasAuthorship W4387614032A5082948468 @default.
- W4387614032 hasConcept C105702510 @default.
- W4387614032 hasConcept C126322002 @default.
- W4387614032 hasConcept C142724271 @default.
- W4387614032 hasConcept C169760540 @default.
- W4387614032 hasConcept C2779134260 @default.
- W4387614032 hasConcept C2779483572 @default.
- W4387614032 hasConcept C2780496858 @default.
- W4387614032 hasConcept C2780775167 @default.
- W4387614032 hasConcept C529278444 @default.
- W4387614032 hasConcept C533869091 @default.
- W4387614032 hasConcept C551621295 @default.
- W4387614032 hasConcept C71924100 @default.
- W4387614032 hasConcept C86803240 @default.
- W4387614032 hasConceptScore W4387614032C105702510 @default.
- W4387614032 hasConceptScore W4387614032C126322002 @default.
- W4387614032 hasConceptScore W4387614032C142724271 @default.
- W4387614032 hasConceptScore W4387614032C169760540 @default.
- W4387614032 hasConceptScore W4387614032C2779134260 @default.
- W4387614032 hasConceptScore W4387614032C2779483572 @default.
- W4387614032 hasConceptScore W4387614032C2780496858 @default.
- W4387614032 hasConceptScore W4387614032C2780775167 @default.
- W4387614032 hasConceptScore W4387614032C529278444 @default.