Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387614600> ?p ?o ?g. }
- W4387614600 endingPage "1860" @default.
- W4387614600 startingPage "1860" @default.
- W4387614600 abstract "To investigate the impact of betaine on high-carbohydrate-diet-induced oxidative stress and endoplasmic reticulum (ER) stress, mandarin fish (Siniperca chuatsi) (23.73 ± 0.05 g) were fed with control (NC), betaine (BET), high carbohydrate (HC), and high carbohydrate + betaine (HC + BET) diets for 8 weeks. The results showed that betaine significantly promoted the growth of mandarin fish irrespective of the dietary carbohydrate levels. The HC diet induced oxidative stress, as evidenced by significantly elevated MDA levels. The HC diet significantly stimulated the mRNA levels of genes involved in ER stress (ire1, perk, atf6, xbp1, eif2α, atf4, chop), autophagy (ulk1, becn1, lc3b), and apoptosis (bax). However, betaine mitigated HC-diet-induced oxidative stress by modulating antioxidant enzymes and alleviated ER stress by regulating the mRNA of genes in the PERK-eIF2a-ATF4 pathway. Additionally, betaine significantly reduced the mRNA levels of becn1 and bax, along with the apoptosis rate, indicating a mitigating effect on autophagy and apoptosis. Overall, dietary betaine improved growth, attenuated HC-diet-induced oxidative stress and ER stress, and ultimately alleviated apoptosis in mandarin fish. These findings provide evidence for the use of betaine in aquafeeds to counter disruptive effects due to diets containing high carbohydrate levels." @default.
- W4387614600 created "2023-10-14" @default.
- W4387614600 creator A5000135673 @default.
- W4387614600 creator A5003850660 @default.
- W4387614600 creator A5012031734 @default.
- W4387614600 creator A5023127518 @default.
- W4387614600 creator A5024091383 @default.
- W4387614600 creator A5027009357 @default.
- W4387614600 creator A5032719475 @default.
- W4387614600 creator A5038015706 @default.
- W4387614600 creator A5040133021 @default.
- W4387614600 creator A5053540196 @default.
- W4387614600 creator A5074521681 @default.
- W4387614600 creator A5089979136 @default.
- W4387614600 date "2023-10-13" @default.
- W4387614600 modified "2023-10-15" @default.
- W4387614600 title "Dietary Betaine Attenuates High-Carbohydrate-Diet-Induced Oxidative Stress, Endoplasmic Reticulum Stress, and Apoptosis in Mandarin Fish (Siniperca chuatsi)" @default.
- W4387614600 cites W1976921001 @default.
- W4387614600 cites W1981015458 @default.
- W4387614600 cites W1987554212 @default.
- W4387614600 cites W1999319284 @default.
- W4387614600 cites W2016073278 @default.
- W4387614600 cites W2031266191 @default.
- W4387614600 cites W2044366634 @default.
- W4387614600 cites W2046114096 @default.
- W4387614600 cites W2059793223 @default.
- W4387614600 cites W2061876807 @default.
- W4387614600 cites W2070947564 @default.
- W4387614600 cites W2108244474 @default.
- W4387614600 cites W2116938728 @default.
- W4387614600 cites W2136729555 @default.
- W4387614600 cites W2258537433 @default.
- W4387614600 cites W2519786994 @default.
- W4387614600 cites W2736054471 @default.
- W4387614600 cites W2757383628 @default.
- W4387614600 cites W2790971762 @default.
- W4387614600 cites W2794139372 @default.
- W4387614600 cites W2801181155 @default.
- W4387614600 cites W2801361873 @default.
- W4387614600 cites W2883252549 @default.
- W4387614600 cites W2954735427 @default.
- W4387614600 cites W2965405792 @default.
- W4387614600 cites W3006845506 @default.
- W4387614600 cites W3014439662 @default.
- W4387614600 cites W3026052200 @default.
- W4387614600 cites W3035788786 @default.
- W4387614600 cites W3112410272 @default.
- W4387614600 cites W3113178730 @default.
- W4387614600 cites W3126935384 @default.
- W4387614600 cites W3131231783 @default.
- W4387614600 cites W3131906225 @default.
- W4387614600 cites W3174357607 @default.
- W4387614600 cites W3185987838 @default.
- W4387614600 cites W3192987389 @default.
- W4387614600 cites W3199813447 @default.
- W4387614600 cites W3206102331 @default.
- W4387614600 cites W4221097526 @default.
- W4387614600 cites W4254801662 @default.
- W4387614600 cites W4280574361 @default.
- W4387614600 cites W4283362923 @default.
- W4387614600 cites W4293217046 @default.
- W4387614600 cites W4361278524 @default.
- W4387614600 doi "https://doi.org/10.3390/antiox12101860" @default.
- W4387614600 hasPublicationYear "2023" @default.
- W4387614600 type Work @default.
- W4387614600 citedByCount "0" @default.
- W4387614600 crossrefType "journal-article" @default.
- W4387614600 hasAuthorship W4387614600A5000135673 @default.
- W4387614600 hasAuthorship W4387614600A5003850660 @default.
- W4387614600 hasAuthorship W4387614600A5012031734 @default.
- W4387614600 hasAuthorship W4387614600A5023127518 @default.
- W4387614600 hasAuthorship W4387614600A5024091383 @default.
- W4387614600 hasAuthorship W4387614600A5027009357 @default.
- W4387614600 hasAuthorship W4387614600A5032719475 @default.
- W4387614600 hasAuthorship W4387614600A5038015706 @default.
- W4387614600 hasAuthorship W4387614600A5040133021 @default.
- W4387614600 hasAuthorship W4387614600A5053540196 @default.
- W4387614600 hasAuthorship W4387614600A5074521681 @default.
- W4387614600 hasAuthorship W4387614600A5089979136 @default.
- W4387614600 hasBestOaLocation W43876146001 @default.
- W4387614600 hasConcept C104317684 @default.
- W4387614600 hasConcept C126322002 @default.
- W4387614600 hasConcept C134018914 @default.
- W4387614600 hasConcept C139447449 @default.
- W4387614600 hasConcept C158617107 @default.
- W4387614600 hasConcept C185592680 @default.
- W4387614600 hasConcept C190283241 @default.
- W4387614600 hasConcept C2776151105 @default.
- W4387614600 hasConcept C2777248517 @default.
- W4387614600 hasConcept C2778004101 @default.
- W4387614600 hasConcept C2781331208 @default.
- W4387614600 hasConcept C54458228 @default.
- W4387614600 hasConcept C55493867 @default.
- W4387614600 hasConcept C67705224 @default.
- W4387614600 hasConcept C71924100 @default.
- W4387614600 hasConcept C86803240 @default.
- W4387614600 hasConceptScore W4387614600C104317684 @default.
- W4387614600 hasConceptScore W4387614600C126322002 @default.