Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387617086> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4387617086 abstract "Abstract Immunotherapy has become a mainstay of treatment for many cancers. Multiple immune checkpoint inhibitors have been used to treat malignancies, including anti‐programed death‐1 (PD1) and anti‐cytotoxic T‐lymphocyte‐associated protein (anti‐CTLA4). However, a significant percentage of patients develop resistance to these immunotherapy drugs. Therefore, novel strategies were developed to target other aspects of the immune response. Lymphocyte activation gene‐3 (LAG‐3) is a cell‐surface molecule found on natural killer cells and activated T‐cells which negatively regulates T‐cell proliferation and function. LAG‐3 inhibitors interact with LAG‐3 ligands on the surface of T‐cells to block T‐regulatory (Treg) cell activity, suppress cytokine secretion and restore dysfunctional effector T‐cells which subsequently attack and destroy cancer cells. This review reports the dermatologic side effects associated with LAG‐3 inhibitors used in the treatment of melanomas. Using PRISMA 2022 guidelines, a comprehensive literature review of PubMed, Google Scholar, Embase, Cochrane, and Web of Science databases was conducted. Three studies were identified that demonstrated that the use of LAG‐3 inhibitors, whether as a single agent or in combination with other immune checkpoint inhibitors, resulted in stomatitis, pruritus, rash, dry skin, erythema, and vitiligo. Further research is warranted to assess the cutaneous adverse events observed with LAG‐3 inhibitors in treating melanoma and to identify populations most vulnerable to such side effects." @default.
- W4387617086 created "2023-10-14" @default.
- W4387617086 creator A5032911403 @default.
- W4387617086 creator A5041846104 @default.
- W4387617086 creator A5042947073 @default.
- W4387617086 creator A5043515027 @default.
- W4387617086 creator A5044226830 @default.
- W4387617086 creator A5045309602 @default.
- W4387617086 creator A5059947828 @default.
- W4387617086 creator A5093059419 @default.
- W4387617086 creator A5093059420 @default.
- W4387617086 date "2023-10-13" @default.
- W4387617086 modified "2023-10-15" @default.
- W4387617086 title "Cutaneous adverse effects associated with LAG‐3 inhibitor use in cancer treatment: A systematic review" @default.
- W4387617086 cites W2019035934 @default.
- W4387617086 cites W2128758225 @default.
- W4387617086 cites W2132916434 @default.
- W4387617086 cites W2234757355 @default.
- W4387617086 cites W2329871425 @default.
- W4387617086 cites W2776592021 @default.
- W4387617086 cites W2895132169 @default.
- W4387617086 cites W2898897253 @default.
- W4387617086 cites W2965873243 @default.
- W4387617086 cites W2982786601 @default.
- W4387617086 cites W3047452123 @default.
- W4387617086 cites W3085860981 @default.
- W4387617086 cites W3095960113 @default.
- W4387617086 cites W3118849389 @default.
- W4387617086 cites W3134877629 @default.
- W4387617086 cites W3161171821 @default.
- W4387617086 cites W3196371070 @default.
- W4387617086 cites W4214685750 @default.
- W4387617086 cites W4225394054 @default.
- W4387617086 doi "https://doi.org/10.1002/ski2.296" @default.
- W4387617086 hasPublicationYear "2023" @default.
- W4387617086 type Work @default.
- W4387617086 citedByCount "0" @default.
- W4387617086 crossrefType "journal-article" @default.
- W4387617086 hasAuthorship W4387617086A5032911403 @default.
- W4387617086 hasAuthorship W4387617086A5041846104 @default.
- W4387617086 hasAuthorship W4387617086A5042947073 @default.
- W4387617086 hasAuthorship W4387617086A5043515027 @default.
- W4387617086 hasAuthorship W4387617086A5044226830 @default.
- W4387617086 hasAuthorship W4387617086A5045309602 @default.
- W4387617086 hasAuthorship W4387617086A5059947828 @default.
- W4387617086 hasAuthorship W4387617086A5093059419 @default.
- W4387617086 hasAuthorship W4387617086A5093059420 @default.
- W4387617086 hasBestOaLocation W43876170861 @default.
- W4387617086 hasConcept C121608353 @default.
- W4387617086 hasConcept C126322002 @default.
- W4387617086 hasConcept C154317977 @default.
- W4387617086 hasConcept C197934379 @default.
- W4387617086 hasConcept C202751555 @default.
- W4387617086 hasConcept C203014093 @default.
- W4387617086 hasConcept C2777658100 @default.
- W4387617086 hasConcept C2777701055 @default.
- W4387617086 hasConcept C2778570526 @default.
- W4387617086 hasConcept C2779980618 @default.
- W4387617086 hasConcept C502942594 @default.
- W4387617086 hasConcept C55493867 @default.
- W4387617086 hasConcept C71924100 @default.
- W4387617086 hasConcept C86803240 @default.
- W4387617086 hasConcept C8891405 @default.
- W4387617086 hasConcept C98274493 @default.
- W4387617086 hasConceptScore W4387617086C121608353 @default.
- W4387617086 hasConceptScore W4387617086C126322002 @default.
- W4387617086 hasConceptScore W4387617086C154317977 @default.
- W4387617086 hasConceptScore W4387617086C197934379 @default.
- W4387617086 hasConceptScore W4387617086C202751555 @default.
- W4387617086 hasConceptScore W4387617086C203014093 @default.
- W4387617086 hasConceptScore W4387617086C2777658100 @default.
- W4387617086 hasConceptScore W4387617086C2777701055 @default.
- W4387617086 hasConceptScore W4387617086C2778570526 @default.
- W4387617086 hasConceptScore W4387617086C2779980618 @default.
- W4387617086 hasConceptScore W4387617086C502942594 @default.
- W4387617086 hasConceptScore W4387617086C55493867 @default.
- W4387617086 hasConceptScore W4387617086C71924100 @default.
- W4387617086 hasConceptScore W4387617086C86803240 @default.
- W4387617086 hasConceptScore W4387617086C8891405 @default.
- W4387617086 hasConceptScore W4387617086C98274493 @default.
- W4387617086 hasLocation W43876170861 @default.
- W4387617086 hasOpenAccess W4387617086 @default.
- W4387617086 hasPrimaryLocation W43876170861 @default.
- W4387617086 hasRelatedWork W1970734801 @default.
- W4387617086 hasRelatedWork W2083264940 @default.
- W4387617086 hasRelatedWork W2122536851 @default.
- W4387617086 hasRelatedWork W2328367421 @default.
- W4387617086 hasRelatedWork W2361302679 @default.
- W4387617086 hasRelatedWork W2376842615 @default.
- W4387617086 hasRelatedWork W3193583429 @default.
- W4387617086 hasRelatedWork W3210188798 @default.
- W4387617086 hasRelatedWork W4249208820 @default.
- W4387617086 hasRelatedWork W3083702052 @default.
- W4387617086 isParatext "false" @default.
- W4387617086 isRetracted "false" @default.
- W4387617086 workType "article" @default.