Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387617352> ?p ?o ?g. }
Showing items 1 to 59 of
59
with 100 items per page.
- W4387617352 endingPage "77" @default.
- W4387617352 startingPage "71" @default.
- W4387617352 abstract "Introduction. Persistent postsurgical pain (PPSP) or chronic postsurgical pain (CPSP) is recognized as a relevantpostoperative complication. Inadequate pain management in the early postoperative period may contribute to the development of hyperalgesia and the use of local anesthetics in regional anesthesia can help in its treatment and prevention.The aim of the study was to study the eff ectiveness of regional analgesia techniques in preventing PPSP and hyperalgesiain children after anterior abdominal wall surgery and to assess quality of life (QoL) using the Cognitive Functioning Scale.Material and Methods. The study included 87 children at the age of 7-18 years who underwent anterior abdominal wallsurgery with diff erent anesthetic techniques. Group I included 27 children who underwent anterior abdominal wall surgery under general anesthesia using the transversalis fascia plane block (TFPB), combined with the quadratus lumborum block 4 (QLB-4). Group II comprised 33 children who underwent anterior abdominal wall surgery under general anesthesia using fentanyl. Group III consisted of 27 children who underwent anterior abdominal wall surgery under general anesthesia using the TFPB. General anesthesia included either inhalation anesthesia or propofol infusion. The control group included 30 healthy children whose cognitive functioning was assessed. All clinical and laboratory studies were conducted in accordance with the World Medical Association Declaration of Helsinki “Ethical Principles for Medical Research Involving Human Subjects”. According to the Law, prior to a subject’s participation in the study, a written informed consent form was signed by each subject (parents/adult guardians). The manuscript was approved by the Ethics Committee of the Communal Non- Profi t Enterprise “Ivano- Frankivsk Regional Children’s Clinical Hospital of Ivano-Frankivsk Regional Council”, as evidenced by an Excerpt from the Minute of the Committee Meeting No. 2 dated February 24, 2022.The results obtained were statistically processed using statistical measures of variation, correlation analysis, Student’s t-test.Diff erences were considered statistically signifi cant at p<0.05. The proportions were statistically compared by a z-test.The study is a fragment of the research project of the Department of Children Diseases of Postgraduate Medical EducationFaculty, Ivano- Frankivsk National Medical University “Health Status and Adaption of Children from the Precarpathian Regionwith Somatic Diseases, Their Prevention” (state registration number 0121U111129; 2021-2026).Results. A signifi cantly higher mechanical pain threshold was observed in children of Group I and Group III both three(226.422.2, 220.318.6, and 182.414.2 g/mm2, respectively, рІ-ІІ<0.05, рІІ-ІІІ<0.05) and six months (288.214.4, 276.414.8,and 174.216.4 g/mm2, respectively, рІ-ІІ<0.05, рІІ-ІІІ<0.05) after surgery.The surface area of hyperalgesia in children of Group I and Group III was signifi cantly smaller as compared to childrenof Group II three (68.69.4, 79.411.4, and 116.814.0 mm2, respectively, рІ-ІІ<0.05, рІІ-ІІІ<0.05) and six months (70.213.0,77.213.2, and 117.212.6 mm2, respectively, рІ-ІІ<0.05, рІІ-ІІІ<0.050) after surgery.The frequency of CPSP was higher in children of Group II (21%) as compared to children in Group I (4%) and Group III(11%). Additionally, assessing chronic pain with the DN4 questionnaire showed its signifi cantly lower level in children of Group Iand Group III as compared to Group II six months after surgery (5.46±0.42, 8.69±0.78, and 13.69±0.38 points, respectively,рІ-ІІ<0.05, рІІ-ІІІ<0.05, рІ-ІІІ<0.05). No statistically signifi cant diff erence in QoL assessment on the Cognitive Functioning Scale was observed on the 7th day following surgery; the QoL scores in all the groups were signifi cantly lower compared to the control group. Three months after surgery, QoL was signifi cantly lower in children of Group II (69.38±6.93 points) as compared to children of Group I (92.08±4.46 points, pІ-ІІ<0.001) and Group III (83.54±4.16 points, pІІ-ІІІ<0.01). Six months following surgery, the lowest QoL was diagnosed in children of Group II (72.08±6.64) as compared to those in Group І (94.17±4.36 points, p<0.001) and Group ІІІ (91.67±4.27, p<0.001).Conclusions.1. The use of general analgesia in combination with regional anesthesia techniques (TFPB or TFPB+QLB) was associatedwith a higher mechanical pain threshold and a smaller area of hyperalgesia around the postoperative wound three and six months after anterior abdominal wall surgery, compared to conventional anesthesia.2. In addition, combined use of regional (TFPB or QLB+TFPB) with general anesthesia demonstrated a lower frequencyof CPSP, a lower level of chronic pain, and a higher level of cognitive functioning in children throughout these time intervals.3. The results obtained provide a foundation for introducing these analgesia techniques (TFPB or TFPB+QLB) in pediatricpatients undergoing anterior abdominal wall surgery, with the aim of mitigating the eff ects of pain syndrome and improving their Qo L." @default.
- W4387617352 created "2023-10-14" @default.
- W4387617352 creator A5083997733 @default.
- W4387617352 date "2023-10-12" @default.
- W4387617352 modified "2023-10-15" @default.
- W4387617352 title "MANAGEMENT OF CHRONIC POSTSURGICAL PAIN AND HYPERALGESIA IN CHILDREN AND ITS INFLUENCE ON COGNITIVE FUNCTIONING" @default.
- W4387617352 doi "https://doi.org/10.24061/2413-4260.xiii.3.49.2023.10" @default.
- W4387617352 hasPublicationYear "2023" @default.
- W4387617352 type Work @default.
- W4387617352 citedByCount "0" @default.
- W4387617352 crossrefType "journal-article" @default.
- W4387617352 hasAuthorship W4387617352A5083997733 @default.
- W4387617352 hasBestOaLocation W43876173521 @default.
- W4387617352 hasConcept C126322002 @default.
- W4387617352 hasConcept C141071460 @default.
- W4387617352 hasConcept C142724271 @default.
- W4387617352 hasConcept C15490471 @default.
- W4387617352 hasConcept C170493617 @default.
- W4387617352 hasConcept C204787440 @default.
- W4387617352 hasConcept C2776277131 @default.
- W4387617352 hasConcept C2779245659 @default.
- W4387617352 hasConcept C2780120127 @default.
- W4387617352 hasConcept C2781072394 @default.
- W4387617352 hasConcept C42219234 @default.
- W4387617352 hasConcept C68122502 @default.
- W4387617352 hasConcept C71924100 @default.
- W4387617352 hasConceptScore W4387617352C126322002 @default.
- W4387617352 hasConceptScore W4387617352C141071460 @default.
- W4387617352 hasConceptScore W4387617352C142724271 @default.
- W4387617352 hasConceptScore W4387617352C15490471 @default.
- W4387617352 hasConceptScore W4387617352C170493617 @default.
- W4387617352 hasConceptScore W4387617352C204787440 @default.
- W4387617352 hasConceptScore W4387617352C2776277131 @default.
- W4387617352 hasConceptScore W4387617352C2779245659 @default.
- W4387617352 hasConceptScore W4387617352C2780120127 @default.
- W4387617352 hasConceptScore W4387617352C2781072394 @default.
- W4387617352 hasConceptScore W4387617352C42219234 @default.
- W4387617352 hasConceptScore W4387617352C68122502 @default.
- W4387617352 hasConceptScore W4387617352C71924100 @default.
- W4387617352 hasIssue "3(49)" @default.
- W4387617352 hasLocation W43876173521 @default.
- W4387617352 hasOpenAccess W4387617352 @default.
- W4387617352 hasPrimaryLocation W43876173521 @default.
- W4387617352 hasRelatedWork W2134833122 @default.
- W4387617352 hasRelatedWork W2156760585 @default.
- W4387617352 hasRelatedWork W2350990453 @default.
- W4387617352 hasRelatedWork W2371192730 @default.
- W4387617352 hasRelatedWork W2376741896 @default.
- W4387617352 hasRelatedWork W2377801525 @default.
- W4387617352 hasRelatedWork W2380400545 @default.
- W4387617352 hasRelatedWork W2398203438 @default.
- W4387617352 hasRelatedWork W2412134487 @default.
- W4387617352 hasRelatedWork W3028920751 @default.
- W4387617352 hasVolume "8" @default.
- W4387617352 isParatext "false" @default.
- W4387617352 isRetracted "false" @default.
- W4387617352 workType "article" @default.