FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387617557> ?p ?o ?g. }

• W4387617557 endingPage "15156" @default.
• W4387617557 startingPage "15156" @default.
• W4387617557 abstract "Mutations in the FKBP14 gene encoding the endoplasmic reticulum resident collagen-related proline isomerase FK506 binding protein 22 kDa (FKBP22) result in kyphoscoliotic Ehlers–Danlos Syndrome (EDS), which is characterized by a broad phenotypic outcome. A plausible explanation for this outcome is that FKBP22 participates in the biosynthesis of subsets of collagen types: FKBP22 selectively binds to collagens III, IV, VI, and X, but not to collagens I, II, V, and XI. However, these binding mechanisms have never been explored, and they may underpin EDS subtype heterogeneity. Here, we used collagen Toolkit peptide libraries to investigate binding specificity. We observed that FKBP22 binding was distributed along the collagen helix. Further, it (1) was higher on collagen III than collagen II peptides and it (2) was correlated with a positive peptide charge. These findings begin to elucidate the mechanism by which FKBP22 interacts with collagen." @default.
• W4387617557 created "2023-10-14" @default.
• W4387617557 creator A5049835634 @default.
• W4387617557 creator A5057515518 @default.
• W4387617557 creator A5062427842 @default.
• W4387617557 creator A5074848089 @default.
• W4387617557 date "2023-10-13" @default.
• W4387617557 modified "2023-10-15" @default.
• W4387617557 title "Local Net Charge State of Collagen Triple Helix Is a Determinant of FKBP22 Binding to Collagen III" @default.
• W4387617557 cites W1537816308 @default.
• W4387617557 cites W1968669612 @default.
• W4387617557 cites W1973629918 @default.
• W4387617557 cites W1979648280 @default.
• W4387617557 cites W1991335938 @default.
• W4387617557 cites W1994656702 @default.
• W4387617557 cites W1995234808 @default.
• W4387617557 cites W1996266076 @default.
• W4387617557 cites W2023770415 @default.
• W4387617557 cites W2025790095 @default.
• W4387617557 cites W2028939846 @default.
• W4387617557 cites W2050847411 @default.
• W4387617557 cites W2076489078 @default.
• W4387617557 cites W2082855409 @default.
• W4387617557 cites W2111180133 @default.
• W4387617557 cites W2112474407 @default.
• W4387617557 cites W2122860492 @default.
• W4387617557 cites W2126349905 @default.
• W4387617557 cites W2129656993 @default.
• W4387617557 cites W2144284050 @default.
• W4387617557 cites W2150386615 @default.
• W4387617557 cites W2154209855 @default.
• W4387617557 cites W2158181018 @default.
• W4387617557 cites W2341686304 @default.
• W4387617557 cites W2604535029 @default.
• W4387617557 cites W2626529117 @default.
• W4387617557 cites W2903651804 @default.
• W4387617557 cites W2904190519 @default.
• W4387617557 cites W2911685473 @default.
• W4387617557 cites W2913284322 @default.
• W4387617557 cites W2949126681 @default.
• W4387617557 cites W2951809463 @default.
• W4387617557 cites W2999762832 @default.
• W4387617557 cites W3045511029 @default.
• W4387617557 cites W3150533879 @default.
• W4387617557 cites W3160616679 @default.
• W4387617557 cites W3170021837 @default.
• W4387617557 cites W3173294906 @default.
• W4387617557 cites W3177207667 @default.
• W4387617557 cites W3213081077 @default.
• W4387617557 cites W4205228614 @default.
• W4387617557 cites W4206477217 @default.
• W4387617557 cites W4211044698 @default.
• W4387617557 cites W4294295438 @default.
• W4387617557 cites W4327857225 @default.
• W4387617557 cites W4383875302 @default.
• W4387617557 doi "https://doi.org/10.3390/ijms242015156" @default.
• W4387617557 hasPublicationYear "2023" @default.
• W4387617557 type Work @default.
• W4387617557 citedByCount "0" @default.
• W4387617557 crossrefType "journal-article" @default.
• W4387617557 hasAuthorship W4387617557A5049835634 @default.
• W4387617557 hasAuthorship W4387617557A5057515518 @default.
• W4387617557 hasAuthorship W4387617557A5062427842 @default.
• W4387617557 hasAuthorship W4387617557A5074848089 @default.
• W4387617557 hasBestOaLocation W43876175571 @default.
• W4387617557 hasConcept C104317684 @default.
• W4387617557 hasConcept C10919887 @default.
• W4387617557 hasConcept C127716648 @default.
• W4387617557 hasConcept C142724271 @default.
• W4387617557 hasConcept C153911025 @default.
• W4387617557 hasConcept C155181932 @default.
• W4387617557 hasConcept C158617107 @default.
• W4387617557 hasConcept C185592680 @default.
• W4387617557 hasConcept C2778333328 @default.
• W4387617557 hasConcept C2779281246 @default.
• W4387617557 hasConcept C2779815552 @default.
• W4387617557 hasConcept C515207424 @default.
• W4387617557 hasConcept C55493867 @default.
• W4387617557 hasConcept C71240020 @default.
• W4387617557 hasConcept C71924100 @default.
• W4387617557 hasConcept C86803240 @default.
• W4387617557 hasConcept C95444343 @default.
• W4387617557 hasConceptScore W4387617557C104317684 @default.
• W4387617557 hasConceptScore W4387617557C10919887 @default.
• W4387617557 hasConceptScore W4387617557C127716648 @default.
• W4387617557 hasConceptScore W4387617557C142724271 @default.
• W4387617557 hasConceptScore W4387617557C153911025 @default.
• W4387617557 hasConceptScore W4387617557C155181932 @default.
• W4387617557 hasConceptScore W4387617557C158617107 @default.
• W4387617557 hasConceptScore W4387617557C185592680 @default.
• W4387617557 hasConceptScore W4387617557C2778333328 @default.
• W4387617557 hasConceptScore W4387617557C2779281246 @default.
• W4387617557 hasConceptScore W4387617557C2779815552 @default.
• W4387617557 hasConceptScore W4387617557C515207424 @default.
• W4387617557 hasConceptScore W4387617557C55493867 @default.
• W4387617557 hasConceptScore W4387617557C71240020 @default.
• W4387617557 hasConceptScore W4387617557C71924100 @default.
• W4387617557 hasConceptScore W4387617557C86803240 @default.

• next