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• W4387617893 abstract "Phosphofructokinase, platelet (PFKP) is a rate-limiting enzyme of glycolysis that plays a decisive role in various human physio-pathological processes. PFKP has been reported to have multiple functions in different cancer types, including lung cancer and breast cancer. However, no systematic pancancer analysis of PFKP has been performed; this type of analysis could elucidate the clinical value of PFKP in terms of diagnosis, prognosis, drug sensitivity, and immunological correlation. Systematic bioinformation analysis of PFKP was performed based on several public datasets, including The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression Project (GTEx), and Human Protein Atlas (HPA). Prospective carcinogenesis of PFKP across cancers was estimated by expression analysis, effect on patient prognosis, diagnosis significance evaluation, and immunity regulation estimation. Then, pancancer functional enrichment of PFKP was also assessed through its effect on the signaling score and gene expression profile. Finally, upstream expression regulation of PFKP was explored by promoter DNA methylation and transcription factor (TF) prediction. Our analysis revealed that high expression of PFKP was found in most cancer types. Additionally, a high level of PFKP displayed a significant correlation with poor prognosis in patients across cancers. The diagnostic value of PFKP was performed based on its positive correlation with programmed cell death-ligand 1 (PD-L1). We also found an obvious immune-regulating effect of PFKP in most cancer types. PFKP also had a strong negative correlation with several cancer drugs. Finally, ectopic expression of PFKP may depend on DNA methylation and several predicated transcription factors, including the KLF (KLF transcription factor) and Sp (Sp transcription factor) families. This pancancer analysis revealed that a high expression level of PFKP might be a useful biomarker and predictor in most cancer types. Additionally, the performance of PFKP across cancers also suggested its meaningful role in cancer immunity regulation, even in immunotherapy and drug resistance. Overall, PFKP might be explored as an auxiliary monitor for pancancer early prognosis and diagnosis." @default.
• W4387617893 created "2023-10-14" @default.
• W4387617893 creator A5019560977 @default.
• W4387617893 creator A5020476286 @default.
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• W4387617893 creator A5057135582 @default.
• W4387617893 creator A5066839346 @default.
• W4387617893 creator A5070996678 @default.
• W4387617893 creator A5089349047 @default.
• W4387617893 creator A5090691485 @default.
• W4387617893 date "2023-10-13" @default.
• W4387617893 modified "2023-10-18" @default.
• W4387617893 title "PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer" @default.
• W4387617893 cites W1533942137 @default.
• W4387617893 cites W1810028515 @default.
• W4387617893 cites W1964485346 @default.
• W4387617893 cites W1968486566 @default.
• W4387617893 cites W1980181091 @default.
• W4387617893 cites W1980276147 @default.
• W4387617893 cites W1985987855 @default.
• W4387617893 cites W1986553481 @default.
• W4387617893 cites W1992553266 @default.
• W4387617893 cites W1998166655 @default.
• W4387617893 cites W2006128086 @default.
• W4387617893 cites W2018838463 @default.
• W4387617893 cites W2028974980 @default.
• W4387617893 cites W2038265792 @default.
• W4387617893 cites W2050658928 @default.
• W4387617893 cites W2052543023 @default.
• W4387617893 cites W2070923004 @default.
• W4387617893 cites W2075094552 @default.
• W4387617893 cites W2094390470 @default.
• W4387617893 cites W2097259163 @default.
• W4387617893 cites W2106876831 @default.
• W4387617893 cites W2114104841 @default.
• W4387617893 cites W2122339465 @default.
• W4387617893 cites W2129824771 @default.
• W4387617893 cites W2130430382 @default.
• W4387617893 cites W2139937771 @default.
• W4387617893 cites W2146512944 @default.
• W4387617893 cites W2147190181 @default.
• W4387617893 cites W2150026213 @default.
• W4387617893 cites W2153960708 @default.
• W4387617893 cites W2156201868 @default.
• W4387617893 cites W2163729820 @default.
• W4387617893 cites W2167142486 @default.
• W4387617893 cites W2223535266 @default.
• W4387617893 cites W2230320310 @default.
• W4387617893 cites W2236270374 @default.
• W4387617893 cites W2520632143 @default.
• W4387617893 cites W2586382778 @default.
• W4387617893 cites W2600038343 @default.
• W4387617893 cites W2763548994 @default.
• W4387617893 cites W2777469091 @default.
• W4387617893 cites W2792793299 @default.
• W4387617893 cites W2795708883 @default.
• W4387617893 cites W2796448036 @default.
• W4387617893 cites W2808182511 @default.
• W4387617893 cites W2884297297 @default.
• W4387617893 cites W2893641062 @default.
• W4387617893 cites W2901942090 @default.
• W4387617893 cites W2915074980 @default.
• W4387617893 cites W2918846942 @default.
• W4387617893 cites W2921434986 @default.
• W4387617893 cites W2926720872 @default.
• W4387617893 cites W2942592603 @default.
• W4387617893 cites W2948113028 @default.
• W4387617893 cites W2952391626 @default.
• W4387617893 cites W2979410128 @default.
• W4387617893 cites W2982216374 @default.
• W4387617893 cites W2985781565 @default.
• W4387617893 cites W2987284967 @default.
• W4387617893 cites W2990427812 @default.
• W4387617893 cites W2992324722 @default.
• W4387617893 cites W3002568562 @default.
• W4387617893 cites W3003310139 @default.
• W4387617893 cites W3006774227 @default.
• W4387617893 cites W3011910925 @default.
• W4387617893 cites W3013214564 @default.
• W4387617893 cites W3029701312 @default.
• W4387617893 cites W3033295591 @default.
• W4387617893 cites W3043393054 @default.
• W4387617893 cites W3083853613 @default.
• W4387617893 cites W3085208914 @default.
• W4387617893 cites W3093872008 @default.
• W4387617893 cites W3097803258 @default.
• W4387617893 cites W3118685952 @default.
• W4387617893 cites W3119486198 @default.
• W4387617893 cites W3124968121 @default.
• W4387617893 cites W3128646645 @default.
• W4387617893 cites W3152675006 @default.
• W4387617893 cites W3159546116 @default.
• W4387617893 cites W3160158271 @default.
• W4387617893 cites W3161540023 @default.
• W4387617893 cites W3162194020 @default.
• W4387617893 cites W3165482261 @default.
• W4387617893 cites W3180859798 @default.
• W4387617893 cites W3182293965 @default.

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