FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387618612> ?p ?o ?g. }

• W4387618612 endingPage "140399" @default.
• W4387618612 startingPage "140399" @default.
• W4387618612 abstract "Zebrafish embryos (ZFE) is a widely used model organism, employed in various research fields including toxicology to assess e.g., developmental toxicity and endocrine disruption. Variation in effects between chemicals are difficult to compare using nominal dose as toxicokinetic properties may vary. Toxicokinetic (TK) modeling is a means to estimate internal exposure concentration or dose at target and to enable extrapolation between experimental conditions and species, thereby improving hazard assessment of potential pollutants. In this study we advance currently existing TK models for ZFE with physiological ZFE parameters and novel experimental bisphenol data, a class of chemicals with suspected endocrine activity. We developed a five-compartment model consisting of water, plastic, chorion, yolk sack and embryo in which surface area and volume changes as well as the processes of biotransformation and blood circulation influence mass fluxes. For model training and validation, we measured internal concentrations in ZFE exposed individually to BPA, bisphenol AF (BPAF) and Z (BPZ). Bayesian inference was applied for parameter calibration based on the training data set of BPZ. The calibrated TK model predicted internal ZFE concentrations of the majority of external test data within a 5-fold error and half of the data within a 2-fold error for bisphenols A, AF, F, and tetrabromo bisphenol A (TBBPA). We used the developed model to rank the hazard of seven bisphenols based on predicted internal concentrations and measured in vitro estrogenicity. This ranking indicated a higher hazard for BPAF, BPZ, bisphenol B and C (BPB, BPC) than for BPA." @default.
• W4387618612 created "2023-10-14" @default.
• W4387618612 creator A5000282192 @default.
• W4387618612 creator A5003545049 @default.
• W4387618612 creator A5017156112 @default.
• W4387618612 creator A5019666082 @default.
• W4387618612 creator A5023275578 @default.
• W4387618612 creator A5036998608 @default.
• W4387618612 creator A5050154266 @default.
• W4387618612 creator A5052652587 @default.
• W4387618612 date "2023-10-01" @default.
• W4387618612 modified "2023-10-17" @default.
• W4387618612 title "Physiology-informed toxicokinetic model for the zebrafish embryo test developed for bisphenols" @default.
• W4387618612 cites W1510645737 @default.
• W4387618612 cites W1896979333 @default.
• W4387618612 cites W1964685885 @default.
• W4387618612 cites W1966871799 @default.
• W4387618612 cites W1967321299 @default.
• W4387618612 cites W1968495751 @default.
• W4387618612 cites W1977059167 @default.
• W4387618612 cites W1980950078 @default.
• W4387618612 cites W1997989074 @default.
• W4387618612 cites W1998577697 @default.
• W4387618612 cites W2000089305 @default.
• W4387618612 cites W2004720743 @default.
• W4387618612 cites W2006642896 @default.
• W4387618612 cites W2019682109 @default.
• W4387618612 cites W2046323606 @default.
• W4387618612 cites W2049784603 @default.
• W4387618612 cites W2054296235 @default.
• W4387618612 cites W2055348439 @default.
• W4387618612 cites W2058969256 @default.
• W4387618612 cites W2060653501 @default.
• W4387618612 cites W2071270368 @default.
• W4387618612 cites W2080671154 @default.
• W4387618612 cites W2083080778 @default.
• W4387618612 cites W2084647418 @default.
• W4387618612 cites W2088708637 @default.
• W4387618612 cites W2104002061 @default.
• W4387618612 cites W2115603195 @default.
• W4387618612 cites W2118292710 @default.
• W4387618612 cites W2120533723 @default.
• W4387618612 cites W2125349610 @default.
• W4387618612 cites W2125375674 @default.
• W4387618612 cites W2129918430 @default.
• W4387618612 cites W2136829296 @default.
• W4387618612 cites W2152771038 @default.
• W4387618612 cites W2160744446 @default.
• W4387618612 cites W2235980518 @default.
• W4387618612 cites W2296706368 @default.
• W4387618612 cites W2314745102 @default.
• W4387618612 cites W2346529285 @default.
• W4387618612 cites W2407404175 @default.
• W4387618612 cites W2510775794 @default.
• W4387618612 cites W2574596039 @default.
• W4387618612 cites W2601980778 @default.
• W4387618612 cites W2605667852 @default.
• W4387618612 cites W2608459997 @default.
• W4387618612 cites W2741978829 @default.
• W4387618612 cites W2757604957 @default.
• W4387618612 cites W2763927309 @default.
• W4387618612 cites W2793283003 @default.
• W4387618612 cites W2795885489 @default.
• W4387618612 cites W2799412961 @default.
• W4387618612 cites W2891382783 @default.
• W4387618612 cites W2903701597 @default.
• W4387618612 cites W2904263060 @default.
• W4387618612 cites W2922019432 @default.
• W4387618612 cites W2947336471 @default.
• W4387618612 cites W2948922151 @default.
• W4387618612 cites W2968421475 @default.
• W4387618612 cites W2971492517 @default.
• W4387618612 cites W2986205825 @default.
• W4387618612 cites W3007728416 @default.
• W4387618612 cites W3021723809 @default.
• W4387618612 cites W3040913956 @default.
• W4387618612 cites W3110866333 @default.
• W4387618612 cites W3137271117 @default.
• W4387618612 cites W3168701632 @default.
• W4387618612 cites W4213255185 @default.
• W4387618612 cites W4221025226 @default.
• W4387618612 cites W4284892499 @default.
• W4387618612 cites W4285499223 @default.
• W4387618612 cites W4294543524 @default.
• W4387618612 cites W4297239417 @default.
• W4387618612 cites W4328053629 @default.
• W4387618612 doi "https://doi.org/10.1016/j.chemosphere.2023.140399" @default.
• W4387618612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37839743" @default.
• W4387618612 hasPublicationYear "2023" @default.
• W4387618612 type Work @default.
• W4387618612 citedByCount "0" @default.
• W4387618612 crossrefType "journal-article" @default.
• W4387618612 hasAuthorship W4387618612A5000282192 @default.
• W4387618612 hasAuthorship W4387618612A5003545049 @default.
• W4387618612 hasAuthorship W4387618612A5017156112 @default.
• W4387618612 hasAuthorship W4387618612A5019666082 @default.
• W4387618612 hasAuthorship W4387618612A5023275578 @default.
• W4387618612 hasAuthorship W4387618612A5036998608 @default.

• next