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- W4387618759 endingPage "115877" @default.
- W4387618759 startingPage "115877" @default.
- W4387618759 abstract "Large amounts of adenosine triphosphate (ATP), a natural P2X7 receptor activator, are released during colorectal carcinogenesis. P2X7 receptor activation regulates the activity of colorectal cancer (CRC) cells by mediating intracellular signal transduction. Importantly, the opening and activation of membrane pores of P2X7 receptor are different, which can play a dual role in promoting or inhibiting the progression of CRC. These can also depend on P2X7 receptor to regulate the activities of immune cells in the microenvironment, play the functions of immune regulation, immune escape and immune monitoring. While the use of P2X7 receptor antagonists (such as BBG, A438079 and A740003) can play a certain inhibitory pharmacological role on the activity of CRC. Therefore, in this paper, the mechanism and immunomodulatory function of P2X7 receptor involved in the progression of CRC were discussed. Moreover, we discussed the effect of antagonizing the activity of P2X7 receptor on the progression of CRC. So P2X7 receptor may be a new pharmacological molecular target for the treatment of CRC." @default.
- W4387618759 created "2023-10-14" @default.
- W4387618759 creator A5005445343 @default.
- W4387618759 creator A5019266352 @default.
- W4387618759 creator A5081117163 @default.
- W4387618759 creator A5089489848 @default.
- W4387618759 date "2023-10-01" @default.
- W4387618759 modified "2023-10-15" @default.
- W4387618759 title "ATP ion channel P2X7 receptor as a regulatory molecule in the progression of colorectal cancer" @default.
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