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- W4387621147 abstract "Diabetes is a growing epidemic, with 37.3 million affected in the US. Diabetic patients are twice as likely to develop cardiovascular disease (CVD). Risk of CVD persists for years even following restoration of glycemic control in type-2-diabetic patients. These findings led to the hypothesis of glycemic memory, i.e., prior changes in glucose levels and delivery may lead to long-term molecular changes predisposing patients to CVD. We proposed that prior enhanced cellular glucose uptake leads to transcriptional changes that contribute to glycemic memory and enhances susceptibility to heart failure. We used a mouse model of doxycycline (DOX)-inducible cardiomyocyte-restricted glucose transporter 4 (GLUT4; mG4H), where mG4H is overexpressed for 2 wk (ON) and then returned to basal levels (OFF). Harvested left ventricular tissues from 4 groups of male mice (n=3) - ON and matched control (Con), OFF and DOX-matched Con (DCon) - were subjected to RNA sequencing analysis (Adjusted P <0.1, Fold-Change>" @default.
- W4387621147 created "2023-10-14" @default.
- W4387621147 creator A5063056855 @default.
- W4387621147 creator A5088762816 @default.
- W4387621147 date "2023-08-04" @default.
- W4387621147 modified "2023-10-15" @default.
- W4387621147 title "Abstract P1135: Gene Expression Analysis Of Glycemic Memory In Heart Failure" @default.
- W4387621147 doi "https://doi.org/10.1161/res.133.suppl_1.p1135" @default.
- W4387621147 hasPublicationYear "2023" @default.
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