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- W4387631102 endingPage "101217" @default.
- W4387631102 startingPage "101217" @default.
- W4387631102 abstract "The optic nerve consists of the glia, vessels, and axons including myelin and axoplasm. Since axonal degeneration precedes retinal ganglion cell death in glaucoma, the preceding axonal degeneration model may be helpful for understanding the molecular mechanisms of optic nerve degeneration. Optic nerve samples from these models can provide information on several aspects of autophagy. Autophagosomes, the most typical organelles expressing autophagy, are found much more frequently inside axons than around the glia. Thus, immunoblot findings from the optic nerve can reflect the autophagy state in axons. Autophagic flux impairment may occur in degenerating optic nerve axons, as in other central nervous system neurodegenerative diseases. Several molecular candidates are involved in autophagy enhancement, leading to axonal protection. This concept is an attractive approach to the prevention of further retinal ganglion cell death. In this review, we describe the factors affecting autophagy, including nicotinamide riboside, p38, ULK, AMPK, ROCK, and SIRT1, in the optic nerve and propose potential methods of axonal protection via enhancement of autophagy." @default.
- W4387631102 created "2023-10-14" @default.
- W4387631102 creator A5026652978 @default.
- W4387631102 creator A5066693613 @default.
- W4387631102 date "2023-12-01" @default.
- W4387631102 modified "2023-10-17" @default.
- W4387631102 title "Molecular aspects of optic nerve autophagy in glaucoma" @default.
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