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- W4387633295 abstract "At-home urine sampling is commonly used to evaluate renal excretion of biomarkers for diagnostic purposes and therapeutic drug monitoring (TDM). While 24-hr collection is the preferred method, it is commonly associated with sampling errors resulting in incomplete or excessive urine collection. Therefore, more simple and precise sampling methods are needed. We present our studies of urine 2,8-dihydroxyadenine (DHA) quantification in patients with adenine phosphoribosyltransferase (APRT) deficiency, focusing on the comparison between single-void urine samples and 24-hr urine collections. Our findings show a strong correlation between DHA-to-creatinine ratio in first-morning void urine samples and 24-hr urinary DHA excretion. Hence, the use of single-void urine samples for quantification of DHA excretion in patients with APRT deficiency eliminates inaccuracies associated with sampling errors and is more convenient for patients. Simplified and more accurate assessment of urinary DHA excretion will improve TDM and hopefully result in improved outcomes of patients. Future studies will address the use of microsampling for quantification of DHA." @default.
- W4387633295 created "2023-10-14" @default.
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- W4387633295 date "2023-10-13" @default.
- W4387633295 modified "2023-10-15" @default.
- W4387633295 title "Simplification of Home Urine Sampling for Measurement of 2,8‐Dihydroxyadenine in Patients with Adenine Phosphoribosyltransferase Deficiency" @default.
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- W4387633295 doi "https://doi.org/10.1002/9781119615583.ch8" @default.
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