FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387636974> ?p ?o ?g. }

• W4387636974 abstract "The critical point or pivotal threshold of cell transition occurs in early embryonic development when cell differentiation culminates in its transition to specific cell fates, at which the cell population undergoes an abrupt and qualitative shift. Revealing such critical points of cell transitions can track cellular heterogeneity and shed light on the molecular mechanisms of cell differentiation. However, precise detection of critical state transitions proves challenging when relying on single-cell RNA sequencing data due to their inherent sparsity, noise, and heterogeneity. In this study, diverging from conventional methods like differential gene analysis or static techniques that emphasize classification of cell types, an innovative computational approach, single-cell gene association entropy (SGAE), is designed for the analysis of single-cell RNA-seq data and utilizes gene association information to reveal critical states of cell transitions. More specifically, through the translation of gene expression data into local SGAE scores, the proposed SGAE can serve as an index to quantitatively assess the resilience and critical properties of genetic regulatory networks, consequently detecting the signal of cell transitions. Analyses of five single-cell datasets for embryonic development demonstrate that the SGAE method achieves better performance in facilitating the characterization of a critical phase transition compared with other existing methods. Moreover, the SGAE value can effectively discriminate cellular heterogeneity over time and performs well in the temporal clustering of cells. Besides, biological functional analysis also indicates the effectiveness of the proposed approach." @default.
• W4387636974 created "2023-10-15" @default.
• W4387636974 creator A5005904698 @default.
• W4387636974 creator A5026524159 @default.
• W4387636974 creator A5027177185 @default.
• W4387636974 creator A5045431261 @default.
• W4387636974 date "2023-09-22" @default.
• W4387636974 modified "2023-10-15" @default.
• W4387636974 title "SGAE: single-cell gene association entropy for revealing critical states of cell transitions during embryonic development" @default.
• W4387636974 cites W1551705411 @default.
• W4387636974 cites W1967822872 @default.
• W4387636974 cites W2035471593 @default.
• W4387636974 cites W2035618305 @default.
• W4387636974 cites W2051830265 @default.
• W4387636974 cites W2055156816 @default.
• W4387636974 cites W2073483289 @default.
• W4387636974 cites W2073759231 @default.
• W4387636974 cites W2113263838 @default.
• W4387636974 cites W2116199452 @default.
• W4387636974 cites W2142484559 @default.
• W4387636974 cites W2148856565 @default.
• W4387636974 cites W2151982005 @default.
• W4387636974 cites W2159337368 @default.
• W4387636974 cites W2516247999 @default.
• W4387636974 cites W2587655168 @default.
• W4387636974 cites W2608016504 @default.
• W4387636974 cites W2727913218 @default.
• W4387636974 cites W2741536364 @default.
• W4387636974 cites W2761971542 @default.
• W4387636974 cites W2792073521 @default.
• W4387636974 cites W2801926117 @default.
• W4387636974 cites W2921554869 @default.
• W4387636974 cites W2928665623 @default.
• W4387636974 cites W2952938648 @default.
• W4387636974 cites W2980281204 @default.
• W4387636974 cites W3000911580 @default.
• W4387636974 cites W3086494447 @default.
• W4387636974 cites W3135480207 @default.
• W4387636974 cites W3165921003 @default.
• W4387636974 cites W3216000180 @default.
• W4387636974 cites W4200461636 @default.
• W4387636974 cites W4225964782 @default.
• W4387636974 cites W4281663889 @default.
• W4387636974 cites W4283737936 @default.
• W4387636974 cites W4294916260 @default.
• W4387636974 cites W4296394052 @default.
• W4387636974 cites W4307218924 @default.
• W4387636974 cites W4312221828 @default.
• W4387636974 cites W4318263951 @default.
• W4387636974 doi "https://doi.org/10.1093/bib/bbad366" @default.
• W4387636974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37833841" @default.
• W4387636974 hasPublicationYear "2023" @default.
• W4387636974 type Work @default.
• W4387636974 citedByCount "0" @default.
• W4387636974 crossrefType "journal-article" @default.
• W4387636974 hasAuthorship W4387636974A5005904698 @default.
• W4387636974 hasAuthorship W4387636974A5026524159 @default.
• W4387636974 hasAuthorship W4387636974A5027177185 @default.
• W4387636974 hasAuthorship W4387636974A5045431261 @default.
• W4387636974 hasConcept C104317684 @default.
• W4387636974 hasConcept C145103041 @default.
• W4387636974 hasConcept C1491633281 @default.
• W4387636974 hasConcept C150194340 @default.
• W4387636974 hasConcept C154945302 @default.
• W4387636974 hasConcept C189014844 @default.
• W4387636974 hasConcept C41008148 @default.
• W4387636974 hasConcept C54355233 @default.
• W4387636974 hasConcept C67339327 @default.
• W4387636974 hasConcept C67705224 @default.
• W4387636974 hasConcept C70721500 @default.
• W4387636974 hasConcept C73555534 @default.
• W4387636974 hasConcept C86803240 @default.
• W4387636974 hasConceptScore W4387636974C104317684 @default.
• W4387636974 hasConceptScore W4387636974C145103041 @default.
• W4387636974 hasConceptScore W4387636974C1491633281 @default.
• W4387636974 hasConceptScore W4387636974C150194340 @default.
• W4387636974 hasConceptScore W4387636974C154945302 @default.
• W4387636974 hasConceptScore W4387636974C189014844 @default.
• W4387636974 hasConceptScore W4387636974C41008148 @default.
• W4387636974 hasConceptScore W4387636974C54355233 @default.
• W4387636974 hasConceptScore W4387636974C67339327 @default.
• W4387636974 hasConceptScore W4387636974C67705224 @default.
• W4387636974 hasConceptScore W4387636974C70721500 @default.
• W4387636974 hasConceptScore W4387636974C73555534 @default.
• W4387636974 hasConceptScore W4387636974C86803240 @default.
• W4387636974 hasFunder F4320321001 @default.
• W4387636974 hasIssue "6" @default.
• W4387636974 hasLocation W43876369741 @default.
• W4387636974 hasLocation W43876369742 @default.
• W4387636974 hasOpenAccess W4387636974 @default.
• W4387636974 hasPrimaryLocation W43876369741 @default.
• W4387636974 hasRelatedWork W1966678537 @default.
• W4387636974 hasRelatedWork W2083665254 @default.
• W4387636974 hasRelatedWork W2132641928 @default.
• W4387636974 hasRelatedWork W2381724992 @default.
• W4387636974 hasRelatedWork W2393816671 @default.
• W4387636974 hasRelatedWork W2804364458 @default.
• W4387636974 hasRelatedWork W4289637626 @default.
• W4387636974 hasRelatedWork W4294862307 @default.
• W4387636974 hasRelatedWork W4298130764 @default.

• next