FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387637134> ?p ?o ?g. }

• W4387637134 abstract "This study aimed to investigate the upstream regulators and specific mechanisms of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the odontoblastic differentiation of human dental pulp stem cells (hDPSCs).Human dental pulp stem cells were isolated and cultured, followed by conducting loss- or gain-of-function experiments on ATF4 and loss experiments on MALAT1 to elucidate their respective biological functions in odontoblastic differentiation. Chromatin immunoprecipitation assays and RNA immunoprecipitation were performed to uncover the interaction between ATF4-MALAT1 and MALAT1-JMJD3, respectively. The odontoblastic differentiation was estimated by the mRNA and protein of DSPP and DMP1, as well as alkaline phosphatase staining.Expression of MALAT1 was upregulated in the hDPSCs cultured in an odontoblastic medium, and MALAT1 downregulation suppressed the odontoblastic differentiation of the hDPSCs. Subsequent experiments confirmed that ATF4 promoted odontoblastic differentiation and induced MALAT1 expression by binding to the MALAT1 promoter region. Further experiments revealed that nuclear MALAT1 interacted with JMJD3. MALAT1 knockdown decreased the JMJD3 protein level and demethylase activity, and it enhanced H3K27me3 occupancy of the promoter region of DSPP and DMP1, resulting in the inhibition of DSPP and DMP1 transcription. Importantly, JMJD3 overexpression significantly attenuated the inhibition of odontoblastic differentiation induced by MALAT1 knockdown.ATF4-regulated MALAT1 plays a positive regulatory role in odontoblastic differentiation of hDPSCs through JMJD3-mediated H3K27me3 modifications of the DSPP and DMP1 promoters." @default.
• W4387637134 created "2023-10-15" @default.
• W4387637134 creator A5003617942 @default.
• W4387637134 creator A5025137502 @default.
• W4387637134 creator A5033054928 @default.
• W4387637134 creator A5051158143 @default.
• W4387637134 creator A5052028129 @default.
• W4387637134 creator A5052843107 @default.
• W4387637134 creator A5063242613 @default.
• W4387637134 date "2023-10-13" @default.
• W4387637134 modified "2023-10-15" @default.
• W4387637134 title "The ATF4‐regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An <i>in vitro</i> study" @default.
• W4387637134 cites W1970728706 @default.
• W4387637134 cites W2005636452 @default.
• W4387637134 cites W2053833990 @default.
• W4387637134 cites W2060905299 @default.
• W4387637134 cites W2061705235 @default.
• W4387637134 cites W2064627937 @default.
• W4387637134 cites W2083837059 @default.
• W4387637134 cites W2085907524 @default.
• W4387637134 cites W2087377443 @default.
• W4387637134 cites W2102795894 @default.
• W4387637134 cites W2111688179 @default.
• W4387637134 cites W2123552387 @default.
• W4387637134 cites W2128619556 @default.
• W4387637134 cites W2130516299 @default.
• W4387637134 cites W2143261086 @default.
• W4387637134 cites W2418308514 @default.
• W4387637134 cites W2585075473 @default.
• W4387637134 cites W2735594703 @default.
• W4387637134 cites W2753564982 @default.
• W4387637134 cites W2789891087 @default.
• W4387637134 cites W2902379508 @default.
• W4387637134 cites W2947420593 @default.
• W4387637134 cites W2982103201 @default.
• W4387637134 cites W2982324044 @default.
• W4387637134 cites W2982711111 @default.
• W4387637134 cites W2985987438 @default.
• W4387637134 cites W3030998623 @default.
• W4387637134 cites W3033791775 @default.
• W4387637134 cites W3046326478 @default.
• W4387637134 cites W3093416332 @default.
• W4387637134 cites W3115812095 @default.
• W4387637134 cites W3115880421 @default.
• W4387637134 cites W3119212432 @default.
• W4387637134 cites W3120607876 @default.
• W4387637134 cites W3129176329 @default.
• W4387637134 cites W3147800719 @default.
• W4387637134 cites W3157908160 @default.
• W4387637134 cites W3163819055 @default.
• W4387637134 cites W3181994568 @default.
• W4387637134 cites W3189822910 @default.
• W4387637134 cites W3193762252 @default.
• W4387637134 cites W3200534519 @default.
• W4387637134 cites W3200650337 @default.
• W4387637134 cites W4207028823 @default.
• W4387637134 doi "https://doi.org/10.1111/iej.13984" @default.
• W4387637134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37837219" @default.
• W4387637134 hasPublicationYear "2023" @default.
• W4387637134 type Work @default.
• W4387637134 citedByCount "0" @default.
• W4387637134 crossrefType "journal-article" @default.
• W4387637134 hasAuthorship W4387637134A5003617942 @default.
• W4387637134 hasAuthorship W4387637134A5025137502 @default.
• W4387637134 hasAuthorship W4387637134A5033054928 @default.
• W4387637134 hasAuthorship W4387637134A5051158143 @default.
• W4387637134 hasAuthorship W4387637134A5052028129 @default.
• W4387637134 hasAuthorship W4387637134A5052843107 @default.
• W4387637134 hasAuthorship W4387637134A5063242613 @default.
• W4387637134 hasConcept C101762097 @default.
• W4387637134 hasConcept C104317684 @default.
• W4387637134 hasConcept C127561419 @default.
• W4387637134 hasConcept C134320426 @default.
• W4387637134 hasConcept C150194340 @default.
• W4387637134 hasConcept C153911025 @default.
• W4387637134 hasConcept C173396325 @default.
• W4387637134 hasConcept C185592680 @default.
• W4387637134 hasConcept C190283241 @default.
• W4387637134 hasConcept C2777267240 @default.
• W4387637134 hasConcept C2777400515 @default.
• W4387637134 hasConcept C2779134362 @default.
• W4387637134 hasConcept C2780900454 @default.
• W4387637134 hasConcept C2781364455 @default.
• W4387637134 hasConcept C28328180 @default.
• W4387637134 hasConcept C502942594 @default.
• W4387637134 hasConcept C55493867 @default.
• W4387637134 hasConcept C62203573 @default.
• W4387637134 hasConcept C64927066 @default.
• W4387637134 hasConcept C68434959 @default.
• W4387637134 hasConcept C86803240 @default.
• W4387637134 hasConcept C95444343 @default.
• W4387637134 hasConceptScore W4387637134C101762097 @default.
• W4387637134 hasConceptScore W4387637134C104317684 @default.
• W4387637134 hasConceptScore W4387637134C127561419 @default.
• W4387637134 hasConceptScore W4387637134C134320426 @default.
• W4387637134 hasConceptScore W4387637134C150194340 @default.
• W4387637134 hasConceptScore W4387637134C153911025 @default.
• W4387637134 hasConceptScore W4387637134C173396325 @default.
• W4387637134 hasConceptScore W4387637134C185592680 @default.
• W4387637134 hasConceptScore W4387637134C190283241 @default.

• next