Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387637731> ?p ?o ?g. }
- W4387637731 endingPage "127454" @default.
- W4387637731 startingPage "127454" @default.
- W4387637731 abstract "Glucosamine (Glu) is a cartilage and joint fluid matrix precursor that modulates osteoarthritic joint changes. To improve the enzymatic stability, glucosamine was developed into nanoglucosamine by the ionic gelation method through sodium tripolyphosphate (TPP) as cross-linking agent. The optimized mass ratio of Glu:TPP was (3:1) with the particle size 163 ± 25 nm and surface charge -5 mV. Then Sinapic acid (SA) as a natural phenolic acid with strong antioxidant and antimicrobial activities has been grafted onto glucosamine nanoparticles (GluNPs) with grafting efficiency (73 ± 6 %). The covalent insertion of SA was confirmed by UV-Vis, FTIR, 1HNMR, XRD, and FESEM analyses and the other physicochemical properties were also characterized. SA-g-GluNPs showed spherical shape with a mean diameter of 255 ± 20 nm and zeta potential +16 mV. The in vitro release profile of SA-g-GluNPs exhibited the sustained and pH-dependent drug release property. SA-g-GluNPs had a more pronounced effect on reducing the elevated levels of LPS-induced oxidative stress and pro-inflammatory cytokines than free SA in the human chondrocyte C28/I2 cell line. Furthermore, the antibacterial properties against E. coli and S. aureus were also improved by SA-g-GluNPs. This study demonstrated the potential of phenolic acid grafted GluNPs in therapeutic drug applications for chondroprotection and food industries." @default.
- W4387637731 created "2023-10-15" @default.
- W4387637731 creator A5013877335 @default.
- W4387637731 creator A5039154387 @default.
- W4387637731 creator A5048299240 @default.
- W4387637731 creator A5087931532 @default.
- W4387637731 creator A5093063452 @default.
- W4387637731 date "2023-10-01" @default.
- W4387637731 modified "2023-10-18" @default.
- W4387637731 title "Grafting of sinapic acid onto glucosamine nanoparticle as a potential therapeutic drug with enhanced anti-inflammatory activities in osteoarthritis treatment" @default.
- W4387637731 cites W1886678420 @default.
- W4387637731 cites W1976028185 @default.
- W4387637731 cites W1993105044 @default.
- W4387637731 cites W2002813710 @default.
- W4387637731 cites W2013460781 @default.
- W4387637731 cites W2021291341 @default.
- W4387637731 cites W2024948107 @default.
- W4387637731 cites W2027020554 @default.
- W4387637731 cites W2032674990 @default.
- W4387637731 cites W2034188923 @default.
- W4387637731 cites W2112981618 @default.
- W4387637731 cites W2120312541 @default.
- W4387637731 cites W2317435305 @default.
- W4387637731 cites W259194763 @default.
- W4387637731 cites W2724362483 @default.
- W4387637731 cites W2734598390 @default.
- W4387637731 cites W2735741919 @default.
- W4387637731 cites W2786389389 @default.
- W4387637731 cites W2792202664 @default.
- W4387637731 cites W2888130281 @default.
- W4387637731 cites W2907504923 @default.
- W4387637731 cites W2924708694 @default.
- W4387637731 cites W2926746486 @default.
- W4387637731 cites W2929577765 @default.
- W4387637731 cites W2944617039 @default.
- W4387637731 cites W2952248722 @default.
- W4387637731 cites W2953632167 @default.
- W4387637731 cites W2969376376 @default.
- W4387637731 cites W2978306126 @default.
- W4387637731 cites W2987904517 @default.
- W4387637731 cites W2997255365 @default.
- W4387637731 cites W3019143491 @default.
- W4387637731 cites W3021255075 @default.
- W4387637731 cites W3034511116 @default.
- W4387637731 cites W3035830820 @default.
- W4387637731 cites W3100312059 @default.
- W4387637731 cites W3126258145 @default.
- W4387637731 cites W3126337882 @default.
- W4387637731 cites W3164652214 @default.
- W4387637731 cites W3210609165 @default.
- W4387637731 cites W4210465387 @default.
- W4387637731 cites W4229069987 @default.
- W4387637731 cites W4296774058 @default.
- W4387637731 cites W4309327120 @default.
- W4387637731 cites W4311134296 @default.
- W4387637731 cites W4386283991 @default.
- W4387637731 doi "https://doi.org/10.1016/j.ijbiomac.2023.127454" @default.
- W4387637731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37844822" @default.
- W4387637731 hasPublicationYear "2023" @default.
- W4387637731 type Work @default.
- W4387637731 citedByCount "0" @default.
- W4387637731 crossrefType "journal-article" @default.
- W4387637731 hasAuthorship W4387637731A5013877335 @default.
- W4387637731 hasAuthorship W4387637731A5039154387 @default.
- W4387637731 hasAuthorship W4387637731A5048299240 @default.
- W4387637731 hasAuthorship W4387637731A5087931532 @default.
- W4387637731 hasAuthorship W4387637731A5093063452 @default.
- W4387637731 hasConcept C13965031 @default.
- W4387637731 hasConcept C142724271 @default.
- W4387637731 hasConcept C147789679 @default.
- W4387637731 hasConcept C155672457 @default.
- W4387637731 hasConcept C171250308 @default.
- W4387637731 hasConcept C178790620 @default.
- W4387637731 hasConcept C185592680 @default.
- W4387637731 hasConcept C187530423 @default.
- W4387637731 hasConcept C192562407 @default.
- W4387637731 hasConcept C204787440 @default.
- W4387637731 hasConcept C2775937945 @default.
- W4387637731 hasConcept C2776164576 @default.
- W4387637731 hasConcept C2778004101 @default.
- W4387637731 hasConcept C2778125326 @default.
- W4387637731 hasConcept C2779732960 @default.
- W4387637731 hasConcept C2780104969 @default.
- W4387637731 hasConcept C521977710 @default.
- W4387637731 hasConcept C523546767 @default.
- W4387637731 hasConcept C54355233 @default.
- W4387637731 hasConcept C71924100 @default.
- W4387637731 hasConcept C86181022 @default.
- W4387637731 hasConcept C86803240 @default.
- W4387637731 hasConceptScore W4387637731C13965031 @default.
- W4387637731 hasConceptScore W4387637731C142724271 @default.
- W4387637731 hasConceptScore W4387637731C147789679 @default.
- W4387637731 hasConceptScore W4387637731C155672457 @default.
- W4387637731 hasConceptScore W4387637731C171250308 @default.
- W4387637731 hasConceptScore W4387637731C178790620 @default.
- W4387637731 hasConceptScore W4387637731C185592680 @default.
- W4387637731 hasConceptScore W4387637731C187530423 @default.
- W4387637731 hasConceptScore W4387637731C192562407 @default.