Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387638245> ?p ?o ?g. }
- W4387638245 endingPage "2788" @default.
- W4387638245 startingPage "2788" @default.
- W4387638245 abstract "Src-kinase associated protein 2 (SKAP2) is an intracellular scaffolding protein that is broadly expressed in immune cells and is involved in various downstream signalling pathways, including, but not limited to, integrin signalling. SKAP2 has a wide range of binding partners and fine-tunes the rearrangement of the cytoskeleton, thereby regulating cell migration and immune cell function. Mutations in SKAP2 have been associated with several inflammatory disorders such as Type 1 Diabetes and Crohn’s disease. Rodent studies showed that SKAP2 deficient immune cells have diminished pathogen clearance due to impaired ROS production and/or phagocytosis. However, there is currently no in-depth understanding of the functioning of SKAP2. Nevertheless, this review summarises the existing knowledge with a focus of its role in signalling cascades involved in cell migration, tissue infiltration and immune cell function." @default.
- W4387638245 created "2023-10-15" @default.
- W4387638245 creator A5060822724 @default.
- W4387638245 creator A5087497309 @default.
- W4387638245 date "2023-10-14" @default.
- W4387638245 modified "2023-10-15" @default.
- W4387638245 title "SKAP2—A Molecule at the Crossroads for Integrin Signalling and Immune Cell Migration and Function" @default.
- W4387638245 cites W1262336387 @default.
- W4387638245 cites W1518815928 @default.
- W4387638245 cites W1895473399 @default.
- W4387638245 cites W1920011500 @default.
- W4387638245 cites W1973528297 @default.
- W4387638245 cites W2003397171 @default.
- W4387638245 cites W2011445628 @default.
- W4387638245 cites W2013627997 @default.
- W4387638245 cites W2018057834 @default.
- W4387638245 cites W2040716340 @default.
- W4387638245 cites W2074409981 @default.
- W4387638245 cites W2078296265 @default.
- W4387638245 cites W2117583909 @default.
- W4387638245 cites W2131717149 @default.
- W4387638245 cites W2136530078 @default.
- W4387638245 cites W2139075939 @default.
- W4387638245 cites W2143069218 @default.
- W4387638245 cites W2148270304 @default.
- W4387638245 cites W2149468314 @default.
- W4387638245 cites W2165804863 @default.
- W4387638245 cites W2208333063 @default.
- W4387638245 cites W2586847280 @default.
- W4387638245 cites W2604876828 @default.
- W4387638245 cites W2747004888 @default.
- W4387638245 cites W2748495954 @default.
- W4387638245 cites W2807901568 @default.
- W4387638245 cites W2886884517 @default.
- W4387638245 cites W2900606149 @default.
- W4387638245 cites W2920879064 @default.
- W4387638245 cites W2922457104 @default.
- W4387638245 cites W2964948494 @default.
- W4387638245 cites W2994719972 @default.
- W4387638245 cites W3021166755 @default.
- W4387638245 cites W3022860460 @default.
- W4387638245 cites W3023707362 @default.
- W4387638245 cites W3089269625 @default.
- W4387638245 cites W3092910755 @default.
- W4387638245 cites W3100433141 @default.
- W4387638245 cites W3177294992 @default.
- W4387638245 cites W3182362580 @default.
- W4387638245 cites W3184273815 @default.
- W4387638245 cites W3204760888 @default.
- W4387638245 cites W3211062415 @default.
- W4387638245 cites W4206231900 @default.
- W4387638245 cites W4220837024 @default.
- W4387638245 cites W4223932115 @default.
- W4387638245 cites W4229452133 @default.
- W4387638245 cites W4294584543 @default.
- W4387638245 cites W4309531101 @default.
- W4387638245 cites W4310939993 @default.
- W4387638245 cites W4378905494 @default.
- W4387638245 doi "https://doi.org/10.3390/biomedicines11102788" @default.
- W4387638245 hasPublicationYear "2023" @default.
- W4387638245 type Work @default.
- W4387638245 citedByCount "0" @default.
- W4387638245 crossrefType "journal-article" @default.
- W4387638245 hasAuthorship W4387638245A5060822724 @default.
- W4387638245 hasAuthorship W4387638245A5087497309 @default.
- W4387638245 hasBestOaLocation W43876382451 @default.
- W4387638245 hasConcept C137738243 @default.
- W4387638245 hasConcept C1491633281 @default.
- W4387638245 hasConcept C160448771 @default.
- W4387638245 hasConcept C184235292 @default.
- W4387638245 hasConcept C195687474 @default.
- W4387638245 hasConcept C203014093 @default.
- W4387638245 hasConcept C55493867 @default.
- W4387638245 hasConcept C62478195 @default.
- W4387638245 hasConcept C66417403 @default.
- W4387638245 hasConcept C82495950 @default.
- W4387638245 hasConcept C86803240 @default.
- W4387638245 hasConcept C8891405 @default.
- W4387638245 hasConcept C95444343 @default.
- W4387638245 hasConcept C97029542 @default.
- W4387638245 hasConceptScore W4387638245C137738243 @default.
- W4387638245 hasConceptScore W4387638245C1491633281 @default.
- W4387638245 hasConceptScore W4387638245C160448771 @default.
- W4387638245 hasConceptScore W4387638245C184235292 @default.
- W4387638245 hasConceptScore W4387638245C195687474 @default.
- W4387638245 hasConceptScore W4387638245C203014093 @default.
- W4387638245 hasConceptScore W4387638245C55493867 @default.
- W4387638245 hasConceptScore W4387638245C62478195 @default.
- W4387638245 hasConceptScore W4387638245C66417403 @default.
- W4387638245 hasConceptScore W4387638245C82495950 @default.
- W4387638245 hasConceptScore W4387638245C86803240 @default.
- W4387638245 hasConceptScore W4387638245C8891405 @default.
- W4387638245 hasConceptScore W4387638245C95444343 @default.
- W4387638245 hasConceptScore W4387638245C97029542 @default.
- W4387638245 hasIssue "10" @default.
- W4387638245 hasLocation W43876382451 @default.
- W4387638245 hasOpenAccess W4387638245 @default.
- W4387638245 hasPrimaryLocation W43876382451 @default.