Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387638462> ?p ?o ?g. }
- W4387638462 endingPage "7095" @default.
- W4387638462 startingPage "7095" @default.
- W4387638462 abstract "The treatment of many bacterial and fungal infections remains a problem due to increasing antibiotic resistance and biofilm formation by pathogens. In the present article, a methodology for the chemoselective synthesis of 2-(1H-indol-3-yl)-1H-benzo[d]imidazole derivatives is presented. We report on the antimicrobial activity of synthesized 2-(1H-indol-3-yl)-1H-benzo[d]imidazoles with significant activity against Staphylococcus aureus ATCC 25923, Staphylococcus aureus ATCC 43300 (MRSA), Mycobacterium smegmatis (mc(2)155/ATCC 700084), and Candida albicans ATCC 10231. High activity against staphylococci was shown by indolylbenzo[d]imidazoles 3ao and 3aq (minimum inhibitory concentration (MIC) < 1 µg/mL) and 3aa and 3ad (MIC 3.9–7.8 µg/mL). A low MIC was demonstrated by 2-(1H-indol-3-yl)-1-methyl-1H-benzo[d]imidazole (3ag) against M. smegmatis and against C. albicans (3.9 µg/mL and 3.9 µg/mL, respectively). 2-(5-Bromo-1H-indol-3-yl)-6,7-dimethyl-1H-benzo[d]imidazole (3aq) showed a low MIC of 3.9 µg/mL against C. albicans. Compounds 3aa, 3ad, 3ao, and 3aq exhibited excellent antibiofilm activity, inhibiting biofilm formation and killing cells in mature biofilms. Molecular docking analysis identified three potential interaction models for the investigated compounds, implicating (p)ppGpp synthetases/hydrolases, FtsZ proteins, or pyruvate kinases in their antibacterial action mechanism." @default.
- W4387638462 created "2023-10-15" @default.
- W4387638462 creator A5031687703 @default.
- W4387638462 creator A5032059595 @default.
- W4387638462 creator A5033877203 @default.
- W4387638462 creator A5035532269 @default.
- W4387638462 creator A5062361390 @default.
- W4387638462 creator A5075961947 @default.
- W4387638462 creator A5087722209 @default.
- W4387638462 creator A5091958297 @default.
- W4387638462 date "2023-10-14" @default.
- W4387638462 modified "2023-10-15" @default.
- W4387638462 title "Synthesis, Antimicrobial and Antibiofilm Activities, and Molecular Docking Investigations of 2-(1H-Indol-3-yl)-1H-benzo[d]imidazole Derivatives" @default.
- W4387638462 cites W1584289074 @default.
- W4387638462 cites W1969192132 @default.
- W4387638462 cites W1974600465 @default.
- W4387638462 cites W1987306535 @default.
- W4387638462 cites W1992246465 @default.
- W4387638462 cites W1993066459 @default.
- W4387638462 cites W1994513825 @default.
- W4387638462 cites W2007322603 @default.
- W4387638462 cites W2021667704 @default.
- W4387638462 cites W2027342467 @default.
- W4387638462 cites W2044160504 @default.
- W4387638462 cites W2056036356 @default.
- W4387638462 cites W2061613274 @default.
- W4387638462 cites W2065187784 @default.
- W4387638462 cites W2066178644 @default.
- W4387638462 cites W2076594842 @default.
- W4387638462 cites W2079057955 @default.
- W4387638462 cites W2084580493 @default.
- W4387638462 cites W2098699979 @default.
- W4387638462 cites W2102780641 @default.
- W4387638462 cites W2106351298 @default.
- W4387638462 cites W2120472530 @default.
- W4387638462 cites W2128936398 @default.
- W4387638462 cites W2132211486 @default.
- W4387638462 cites W2155464523 @default.
- W4387638462 cites W2157931918 @default.
- W4387638462 cites W2295844897 @default.
- W4387638462 cites W2301198416 @default.
- W4387638462 cites W2307908310 @default.
- W4387638462 cites W2312720395 @default.
- W4387638462 cites W2315862471 @default.
- W4387638462 cites W2328375451 @default.
- W4387638462 cites W2342393923 @default.
- W4387638462 cites W2347031408 @default.
- W4387638462 cites W2495846198 @default.
- W4387638462 cites W2550278439 @default.
- W4387638462 cites W2592198540 @default.
- W4387638462 cites W2593634261 @default.
- W4387638462 cites W2656170636 @default.
- W4387638462 cites W2767183726 @default.
- W4387638462 cites W2792054227 @default.
- W4387638462 cites W2799799203 @default.
- W4387638462 cites W2803908719 @default.
- W4387638462 cites W2807091466 @default.
- W4387638462 cites W2897108380 @default.
- W4387638462 cites W2911007981 @default.
- W4387638462 cites W2916389792 @default.
- W4387638462 cites W2923656972 @default.
- W4387638462 cites W2925280433 @default.
- W4387638462 cites W2931144334 @default.
- W4387638462 cites W2950242908 @default.
- W4387638462 cites W2959593012 @default.
- W4387638462 cites W2960942699 @default.
- W4387638462 cites W2970672943 @default.
- W4387638462 cites W3016410128 @default.
- W4387638462 cites W3027193750 @default.
- W4387638462 cites W3083248411 @default.
- W4387638462 cites W3097351870 @default.
- W4387638462 cites W3099575672 @default.
- W4387638462 cites W3107998850 @default.
- W4387638462 cites W3124334671 @default.
- W4387638462 cites W3154267407 @default.
- W4387638462 cites W3177828909 @default.
- W4387638462 cites W3202438559 @default.
- W4387638462 cites W4211220592 @default.
- W4387638462 cites W4225123825 @default.
- W4387638462 cites W4226512826 @default.
- W4387638462 cites W4241912244 @default.
- W4387638462 cites W4291365834 @default.
- W4387638462 cites W4293199754 @default.
- W4387638462 cites W4311419835 @default.
- W4387638462 cites W4365791402 @default.
- W4387638462 cites W4384038421 @default.
- W4387638462 cites W4385342161 @default.
- W4387638462 cites W4386646272 @default.
- W4387638462 doi "https://doi.org/10.3390/molecules28207095" @default.
- W4387638462 hasPublicationYear "2023" @default.
- W4387638462 type Work @default.
- W4387638462 citedByCount "0" @default.
- W4387638462 crossrefType "journal-article" @default.
- W4387638462 hasAuthorship W4387638462A5031687703 @default.
- W4387638462 hasAuthorship W4387638462A5032059595 @default.
- W4387638462 hasAuthorship W4387638462A5033877203 @default.
- W4387638462 hasAuthorship W4387638462A5035532269 @default.
- W4387638462 hasAuthorship W4387638462A5062361390 @default.