Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387639056> ?p ?o ?g. }
- W4387639056 endingPage "4985" @default.
- W4387639056 startingPage "4985" @default.
- W4387639056 abstract "Multidrug resistance is the dominant obstacle to effective chemotherapy for malignant neoplasms. It is well known that neoplastic cells use a wide range of adaptive mechanisms to form and maintain resistance against antitumor agents, which makes it urgent to identify promising therapies to solve this problem. Hydroxamic acids are biologically active compounds and in recent years have been actively considered to be potentially promising drugs of various pharmacological applications. In this paper, we synthesized a number of hydroxamic acids containing a p-substituted cinnamic acid core and bearing bicyclic pinane fragments, including derivatives of (−)-myrtenol, (+)-myrtenol and (−)-nopol, as a Cap-group. Among the synthesized compounds, the most promising hydroxamic acid was identified, containing a fragment of (−)-nopol in the Cap group 18c. This compound synergizes with cisplatin to increase its anticancer effect and overcomes cisplatin resistance, which may be associated with the inhibition of histone deacetylase 1 and glycolytic function. Taken together, our results demonstrate that the use of hydroxamic acids with a bicyclic pinane backbone can be considered to be an effective approach to the eradication of tumor cells and overcoming drug resistance in the treatment of malignant neoplasms." @default.
- W4387639056 created "2023-10-15" @default.
- W4387639056 creator A5033413678 @default.
- W4387639056 creator A5040266350 @default.
- W4387639056 creator A5045070576 @default.
- W4387639056 creator A5053559547 @default.
- W4387639056 creator A5064420566 @default.
- W4387639056 creator A5078661337 @default.
- W4387639056 creator A5080317403 @default.
- W4387639056 date "2023-10-14" @default.
- W4387639056 modified "2023-10-15" @default.
- W4387639056 title "Hydroxamic Acids Containing a Bicyclic Pinane Backbone as Epigenetic and Metabolic Regulators: Synergizing Agents to Overcome Cisplatin Resistance" @default.
- W4387639056 cites W1921071413 @default.
- W4387639056 cites W1968670866 @default.
- W4387639056 cites W1970902931 @default.
- W4387639056 cites W1991376723 @default.
- W4387639056 cites W1996223722 @default.
- W4387639056 cites W2010222729 @default.
- W4387639056 cites W2034451172 @default.
- W4387639056 cites W2053248895 @default.
- W4387639056 cites W2053306599 @default.
- W4387639056 cites W2058111652 @default.
- W4387639056 cites W2064749033 @default.
- W4387639056 cites W2068050569 @default.
- W4387639056 cites W2071579644 @default.
- W4387639056 cites W2079317559 @default.
- W4387639056 cites W2088620463 @default.
- W4387639056 cites W2098087062 @default.
- W4387639056 cites W2108906094 @default.
- W4387639056 cites W2113056756 @default.
- W4387639056 cites W2114413271 @default.
- W4387639056 cites W2129824771 @default.
- W4387639056 cites W2132629607 @default.
- W4387639056 cites W2148420701 @default.
- W4387639056 cites W2159515687 @default.
- W4387639056 cites W2193582402 @default.
- W4387639056 cites W2274595380 @default.
- W4387639056 cites W2279265965 @default.
- W4387639056 cites W2297837302 @default.
- W4387639056 cites W2381727044 @default.
- W4387639056 cites W2396108323 @default.
- W4387639056 cites W2399475545 @default.
- W4387639056 cites W2421614151 @default.
- W4387639056 cites W2478238961 @default.
- W4387639056 cites W2488766111 @default.
- W4387639056 cites W2537817742 @default.
- W4387639056 cites W2563540093 @default.
- W4387639056 cites W2593436234 @default.
- W4387639056 cites W2602265925 @default.
- W4387639056 cites W2794238235 @default.
- W4387639056 cites W2807183240 @default.
- W4387639056 cites W2813910014 @default.
- W4387639056 cites W2912353511 @default.
- W4387639056 cites W2914819801 @default.
- W4387639056 cites W2944236869 @default.
- W4387639056 cites W2945434115 @default.
- W4387639056 cites W2954296232 @default.
- W4387639056 cites W2973053252 @default.
- W4387639056 cites W2974459221 @default.
- W4387639056 cites W2982733831 @default.
- W4387639056 cites W2990089967 @default.
- W4387639056 cites W3010112971 @default.
- W4387639056 cites W3013551968 @default.
- W4387639056 cites W3018583760 @default.
- W4387639056 cites W3020444547 @default.
- W4387639056 cites W3021909056 @default.
- W4387639056 cites W3030151904 @default.
- W4387639056 cites W3041800331 @default.
- W4387639056 cites W3046391818 @default.
- W4387639056 cites W3081044980 @default.
- W4387639056 cites W3089199226 @default.
- W4387639056 cites W3092057003 @default.
- W4387639056 cites W3095031252 @default.
- W4387639056 cites W3108338052 @default.
- W4387639056 cites W3116151560 @default.
- W4387639056 cites W3119005666 @default.
- W4387639056 cites W3122878004 @default.
- W4387639056 cites W3127506405 @default.
- W4387639056 cites W3130965510 @default.
- W4387639056 cites W3133951401 @default.
- W4387639056 cites W3135905016 @default.
- W4387639056 cites W3152901913 @default.
- W4387639056 cites W3159300874 @default.
- W4387639056 cites W3162317822 @default.
- W4387639056 cites W3176010718 @default.
- W4387639056 cites W3179084948 @default.
- W4387639056 cites W3185101141 @default.
- W4387639056 cites W3202108816 @default.
- W4387639056 cites W4205651038 @default.
- W4387639056 cites W4206841660 @default.
- W4387639056 cites W4220667803 @default.
- W4387639056 cites W4220702628 @default.
- W4387639056 cites W4282926494 @default.
- W4387639056 cites W4283032811 @default.
- W4387639056 cites W4283313052 @default.
- W4387639056 cites W4285189441 @default.
- W4387639056 cites W4285401056 @default.
- W4387639056 cites W4285590327 @default.