FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387641106> ?p ?o ?g. }

• W4387641106 endingPage "e01944" @default.
• W4387641106 startingPage "e01944" @default.
• W4387641106 abstract "Malaria continues to be a major public health concern, particularly for children and pregnant women in areas where the disease is endemic. Developing safe and efficient antimalarial therapies to fight the disease is essential. Medicinal plants represent a potential source for the development of new antimalarial drugs. Tetrapleura tetraptera is a plant native to West Africa and traditionally used to treat several diseases including Malaria. Here, we investigated the antiplasmodial activities of T. tetraptera fruit extracts against the chloroquine-sensitive (Pf3D7) and chloroquine-resistant (PfDD2) strains of Plasmodium falciparum in vitro using SYBR green assay. In addition, the antioxidant potential of the fruit extracts was also determined. LC-MS analysis was carried out to identify the bioactive compounds in the extracts. Molecular docking studies provide significant prima facie evidence of inhibition hence, to evaluate the potential inhibition of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH), a validated malaria drug target, the identified compounds were docked against PfDHODH. Strong antiplasmodial activities were demonstrated by the ethyl acetate and ethanolic extracts of T. tetraptera fruit, with IC50 values of 16.12 ± 0.04 µg/mL and 2.06 ± 0.02 µg/mL against the Pf3D7 strain, respectively. In the DPPH radical scavenging experiment, the ethanolic extract revealed considerable antioxidant activity with an EC50 value of 0.21 ± 0.82 mg/mL. Seven bioactive compounds were identified in the extract using LC-MS analysis. N-Methyl-1H-indole-3-propanamide (I), Tazolol (II), and Isopentyl salicylate (III) were identified as potential inhibitors of PfDHODH with high binding affinities ranging from -32.08 to -30.69 kcal/mol. The potential lead compounds also interacted with Gly181, Leu531, and Arg265, which are critical amino acid residues in the catalytic activity of PfDHODH. These findings support the traditional use of T. tetraptera fruit extracts for the treatment of malaria and as promising avenues for antimalarial drug development." @default.
• W4387641106 created "2023-10-15" @default.
• W4387641106 creator A5002431353 @default.
• W4387641106 creator A5013431604 @default.
• W4387641106 creator A5017262117 @default.
• W4387641106 creator A5027364592 @default.
• W4387641106 creator A5037920063 @default.
• W4387641106 creator A5050497866 @default.
• W4387641106 creator A5054484629 @default.
• W4387641106 creator A5063396948 @default.
• W4387641106 creator A5069328322 @default.
• W4387641106 creator A5089942222 @default.
• W4387641106 creator A5092595680 @default.
• W4387641106 creator A5093064122 @default.
• W4387641106 date "2023-10-01" @default.
• W4387641106 modified "2023-10-15" @default.
• W4387641106 title "In vitro Antiplasmodial Activity, LC-MS Analysis, and Molecular Docking Studies of bioactive compounds from Tetrapleura tetraptera (Fabaceae) Fruits" @default.
• W4387641106 cites W1967741223 @default.
• W4387641106 cites W1984021058 @default.
• W4387641106 cites W1998868364 @default.
• W4387641106 cites W2013085020 @default.
• W4387641106 cites W2027123097 @default.
• W4387641106 cites W2037978803 @default.
• W4387641106 cites W2044027291 @default.
• W4387641106 cites W2061079400 @default.
• W4387641106 cites W2089405429 @default.
• W4387641106 cites W2096998441 @default.
• W4387641106 cites W2099167712 @default.
• W4387641106 cites W2103896474 @default.
• W4387641106 cites W2107514091 @default.
• W4387641106 cites W2112099544 @default.
• W4387641106 cites W2117544874 @default.
• W4387641106 cites W2129816308 @default.
• W4387641106 cites W2130580441 @default.
• W4387641106 cites W2156053468 @default.
• W4387641106 cites W2157525511 @default.
• W4387641106 cites W2468291556 @default.
• W4387641106 cites W2482247887 @default.
• W4387641106 cites W2806739079 @default.
• W4387641106 cites W2884323962 @default.
• W4387641106 cites W2884567940 @default.
• W4387641106 cites W2898696707 @default.
• W4387641106 cites W2937203893 @default.
• W4387641106 cites W3027499744 @default.
• W4387641106 cites W3083406432 @default.
• W4387641106 cites W3155645147 @default.
• W4387641106 cites W3165377678 @default.
• W4387641106 cites W4309445154 @default.
• W4387641106 cites W4362508996 @default.
• W4387641106 cites W4367174788 @default.
• W4387641106 cites W4385566518 @default.
• W4387641106 doi "https://doi.org/10.1016/j.sciaf.2023.e01944" @default.
• W4387641106 hasPublicationYear "2023" @default.
• W4387641106 type Work @default.
• W4387641106 citedByCount "0" @default.
• W4387641106 crossrefType "journal-article" @default.
• W4387641106 hasAuthorship W4387641106A5002431353 @default.
• W4387641106 hasAuthorship W4387641106A5013431604 @default.
• W4387641106 hasAuthorship W4387641106A5017262117 @default.
• W4387641106 hasAuthorship W4387641106A5027364592 @default.
• W4387641106 hasAuthorship W4387641106A5037920063 @default.
• W4387641106 hasAuthorship W4387641106A5050497866 @default.
• W4387641106 hasAuthorship W4387641106A5054484629 @default.
• W4387641106 hasAuthorship W4387641106A5063396948 @default.
• W4387641106 hasAuthorship W4387641106A5069328322 @default.
• W4387641106 hasAuthorship W4387641106A5089942222 @default.
• W4387641106 hasAuthorship W4387641106A5092595680 @default.
• W4387641106 hasAuthorship W4387641106A5093064122 @default.
• W4387641106 hasBestOaLocation W43876411061 @default.
• W4387641106 hasConcept C159110408 @default.
• W4387641106 hasConcept C185592680 @default.
• W4387641106 hasConcept C202751555 @default.
• W4387641106 hasConcept C203014093 @default.
• W4387641106 hasConcept C2777425658 @default.
• W4387641106 hasConcept C2777752497 @default.
• W4387641106 hasConcept C2778004101 @default.
• W4387641106 hasConcept C2778048844 @default.
• W4387641106 hasConcept C2778371730 @default.
• W4387641106 hasConcept C2779858419 @default.
• W4387641106 hasConcept C2781401929 @default.
• W4387641106 hasConcept C41685203 @default.
• W4387641106 hasConcept C55493867 @default.
• W4387641106 hasConcept C556039675 @default.
• W4387641106 hasConcept C71924100 @default.
• W4387641106 hasConcept C86803240 @default.
• W4387641106 hasConcept C98274493 @default.
• W4387641106 hasConceptScore W4387641106C159110408 @default.
• W4387641106 hasConceptScore W4387641106C185592680 @default.
• W4387641106 hasConceptScore W4387641106C202751555 @default.
• W4387641106 hasConceptScore W4387641106C203014093 @default.
• W4387641106 hasConceptScore W4387641106C2777425658 @default.
• W4387641106 hasConceptScore W4387641106C2777752497 @default.
• W4387641106 hasConceptScore W4387641106C2778004101 @default.
• W4387641106 hasConceptScore W4387641106C2778048844 @default.
• W4387641106 hasConceptScore W4387641106C2778371730 @default.
• W4387641106 hasConceptScore W4387641106C2779858419 @default.
• W4387641106 hasConceptScore W4387641106C2781401929 @default.
• W4387641106 hasConceptScore W4387641106C41685203 @default.

• next