FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387641198> ?p ?o ?g. }

• W4387641198 endingPage "100853" @default.
• W4387641198 startingPage "100853" @default.
• W4387641198 abstract "High-alkali treatment using sodium hydroxide (NaOH) injection can be a therapeutic approach for killing tumor cells. Alkalization can damage cellular structures and lead to cell death. Increased alkalinity can also enhance the efficacy of certain chemotherapeutic drugs such as doxorubicin (DOX). In this study, NaOH-loaded starch implants (NST implants) were used to induce hyperalkalization (increase pH) in the tumor environment, thereby inducing necrosis and enhancing the effects of DOX. NaOH is a strongly alkaline substance that can increase the pH when injected into a tumor. However, the administration of NaOH can have toxic side effects because it increases the pH of the entire body, not just at the tumor site. To overcome this problem, we developed an injectable NST implant, in which NaOH can be delivered directly into the tumor. This study showed that NST implants could be easily administered intratumorally in mice bearing 4T1 tumors and that most of the NaOH released from the NST implants was delivered to the tumors. Although some NaOH from NST implants can be systemically absorbed, it is neutralized by the body's buffering effect, thereby reducing the risk of toxicity. This study also confirmed both in vitro and in vivo that DOX is more effective at killing 4T1 cells when alkalized. It has been shown that administration of DOX after injection of an NST implant can kill most tumors. Systemic absorption and side effects can be reduced using an NST implant to deliver NaOH to the tumor. In addition, alkalinization induced by NST implants not only exerts anticancer effects but can also enhance the effect of DOX in killing cancer cells. Therefore, the combination of NaOH-loaded starch implants and DOX treatment has the potential to be a novel therapy for tumors." @default.
• W4387641198 created "2023-10-15" @default.
• W4387641198 creator A5034008612 @default.
• W4387641198 date "2023-10-01" @default.
• W4387641198 modified "2023-10-15" @default.
• W4387641198 title "Targeted Hyperalkalization with NaOH-Loaded Starch Implants EnhancesDoxorubicin Efficacy in Tumor Treatment" @default.
• W4387641198 cites W1794873186 @default.
• W4387641198 cites W1965315556 @default.
• W4387641198 cites W1968971179 @default.
• W4387641198 cites W1999069447 @default.
• W4387641198 cites W2044722516 @default.
• W4387641198 cites W2072906500 @default.
• W4387641198 cites W2074420757 @default.
• W4387641198 cites W2076591335 @default.
• W4387641198 cites W2136063757 @default.
• W4387641198 cites W2156687584 @default.
• W4387641198 cites W2169641568 @default.
• W4387641198 cites W2523930288 @default.
• W4387641198 cites W2614736528 @default.
• W4387641198 cites W2806781942 @default.
• W4387641198 cites W2809008737 @default.
• W4387641198 cites W2866631792 @default.
• W4387641198 cites W2899970640 @default.
• W4387641198 cites W2906955107 @default.
• W4387641198 cites W2921487259 @default.
• W4387641198 cites W2941723371 @default.
• W4387641198 cites W2944813678 @default.
• W4387641198 cites W2980216721 @default.
• W4387641198 cites W2984395468 @default.
• W4387641198 cites W2984799663 @default.
• W4387641198 cites W3004200775 @default.
• W4387641198 cites W3014473008 @default.
• W4387641198 cites W3014913757 @default.
• W4387641198 cites W3042923594 @default.
• W4387641198 cites W3118991500 @default.
• W4387641198 cites W3135896406 @default.
• W4387641198 cites W3169930852 @default.
• W4387641198 cites W3170153539 @default.
• W4387641198 cites W4214637505 @default.
• W4387641198 cites W4292678602 @default.
• W4387641198 cites W4295896915 @default.
• W4387641198 cites W4307958844 @default.
• W4387641198 cites W4308019611 @default.
• W4387641198 doi "https://doi.org/10.1016/j.ajps.2023.100853" @default.
• W4387641198 hasPublicationYear "2023" @default.
• W4387641198 type Work @default.
• W4387641198 citedByCount "0" @default.
• W4387641198 crossrefType "journal-article" @default.
• W4387641198 hasAuthorship W4387641198A5034008612 @default.
• W4387641198 hasBestOaLocation W43876411981 @default.
• W4387641198 hasConcept C141071460 @default.
• W4387641198 hasConcept C150903083 @default.
• W4387641198 hasConcept C178790620 @default.
• W4387641198 hasConcept C185592680 @default.
• W4387641198 hasConcept C202751555 @default.
• W4387641198 hasConcept C207001950 @default.
• W4387641198 hasConcept C2776694085 @default.
• W4387641198 hasConcept C2778562268 @default.
• W4387641198 hasConcept C2781303535 @default.
• W4387641198 hasConcept C2781411149 @default.
• W4387641198 hasConcept C29730261 @default.
• W4387641198 hasConcept C45812177 @default.
• W4387641198 hasConcept C502942594 @default.
• W4387641198 hasConcept C55493867 @default.
• W4387641198 hasConcept C71924100 @default.
• W4387641198 hasConcept C86803240 @default.
• W4387641198 hasConcept C98274493 @default.
• W4387641198 hasConceptScore W4387641198C141071460 @default.
• W4387641198 hasConceptScore W4387641198C150903083 @default.
• W4387641198 hasConceptScore W4387641198C178790620 @default.
• W4387641198 hasConceptScore W4387641198C185592680 @default.
• W4387641198 hasConceptScore W4387641198C202751555 @default.
• W4387641198 hasConceptScore W4387641198C207001950 @default.
• W4387641198 hasConceptScore W4387641198C2776694085 @default.
• W4387641198 hasConceptScore W4387641198C2778562268 @default.
• W4387641198 hasConceptScore W4387641198C2781303535 @default.
• W4387641198 hasConceptScore W4387641198C2781411149 @default.
• W4387641198 hasConceptScore W4387641198C29730261 @default.
• W4387641198 hasConceptScore W4387641198C45812177 @default.
• W4387641198 hasConceptScore W4387641198C502942594 @default.
• W4387641198 hasConceptScore W4387641198C55493867 @default.
• W4387641198 hasConceptScore W4387641198C71924100 @default.
• W4387641198 hasConceptScore W4387641198C86803240 @default.
• W4387641198 hasConceptScore W4387641198C98274493 @default.
• W4387641198 hasLocation W43876411981 @default.
• W4387641198 hasOpenAccess W4387641198 @default.
• W4387641198 hasPrimaryLocation W43876411981 @default.
• W4387641198 hasRelatedWork W202183479 @default.
• W4387641198 hasRelatedWork W2040560653 @default.
• W4387641198 hasRelatedWork W2348179995 @default.
• W4387641198 hasRelatedWork W2350156857 @default.
• W4387641198 hasRelatedWork W4207064856 @default.
• W4387641198 hasRelatedWork W4212987871 @default.
• W4387641198 hasRelatedWork W4231291815 @default.
• W4387641198 hasRelatedWork W4234609123 @default.
• W4387641198 hasRelatedWork W4249728238 @default.
• W4387641198 hasRelatedWork W4251036949 @default.
• W4387641198 isParatext "false" @default.

• next