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- W4387641282 abstract "Background Marginal ulceration (MU) is a significant cause of morbidity after Roux-en-Y gastric bypass (RYGB). Proton pump inhibitors (PPI) are the primary treatment. Prior limited data suggest that open-capsule PPI (OC-PPI) improves MU healing compared to intact-capsule PPI (IC-PPI), necessitating further validation. Objectives We aimed to compare healing times of MU after RYGB when treated with OC- versus IC-PPI. Setting Tertiary academic center, United States. Methods We retrospectively analyzed patients with prior RYGB diagnosed with MU from 2012 to 2022. Patients requiring mechanical closure, without documented healing, and without clear PPI prescriptions were excluded. The primary outcome was time to ulcer healing. Log-rank testing and Kaplan Meier survival curve analyses were performed to compare MU healing times when treated with OC- versus IC-PPI. Subgroup analyses further characterized ulcer healing times based on type and dosage of PPI used. Results A total of 108 patients were included for final analysis (38 received OC-PPI and 70 received IC-PPI). Treatment with OC-PPI significantly decreased MU healing time compared to IC-PPI (146.18 vs. 226.14 days [p=0.018]). However, when stratified by PPI potency, the positive effect of opening the capsule lost significance. Conclusion In this study, OC-PPI significantly improved MU healing times compared to IC-PPI in RYGB patients, consistent with prior data. However, on subgroup analysis comparing therapy with similar PPI potency, the MU healing time did not differ with respect to administration method. These results highlight the need for a prospective, randomized trial to compare the true effect of administration method." @default.
- W4387641282 created "2023-10-15" @default.
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- W4387641282 date "2023-10-01" @default.
- W4387641282 modified "2023-10-15" @default.
- W4387641282 title "Is Open-Capsule Proton Pump Inhibitor Associated with Faster Healing Time for Marginal Ulceration After Roux-en-Y Gastric Bypass?" @default.
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- W4387641282 doi "https://doi.org/10.1016/j.soard.2023.10.003" @default.
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