FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4387643263> ?p ?o ?g. }

• W4387643263 endingPage "102243" @default.
• W4387643263 startingPage "102243" @default.
• W4387643263 abstract "Cholangiocarcinoma (CCA) is a serious threat to human health, and tumor development is associated with abnormal mitochondrial function. It is believed that the introduction of healthy mitochondria into tumor cells can induce the oxidative stress in tumor cells to return to normal levels, thus exerting an inhibitory effect on tumor growth. Mitochondria isolated from 143BρW cells were co-cultured with HuCCT1 cells, and the mitochondria were stained with MitoTracker dye as a tracking label. Changes in apoptosis, proliferation, oxidative stress, and PTEN/PI3K/AKT signaling pathway were assessed. In addition, a CCA nude mouse transplantation tumor model was constructed to analyze the effects of mitochondrial transplantation on the above factors in nude mice. Furthermore, the expression of PTEN was interfered to observe the effect and mechanism of mitochondrial transplantation on the proliferation and apoptosis of CCA cells. Mitochondrial transplantation promoted apoptosis and inhibited cell proliferation in CCA cell line. SOD, GSH, and CAT activities were significantly increased, the expression of PTEN was activated, and the expression of p-PI3K and p-AKT were inhibited after mitochondrial transplantation. After mitochondrial transplantation + si-PTEN treatment, cell apoptosis, SOD, GSH, CAT activity, and the expression of PTEN were decreased, while the expression of p-PI3K and p-AKT were significantly enhanced. This study reveals the anti-tumor potential of mitochondrial transplantation through PTEN/PI3K/AKT signaling pathway to regulate cellular oxidative stress in CCA." @default.
• W4387643263 created "2023-10-15" @default.
• W4387643263 creator A5002188808 @default.
• W4387643263 creator A5011365744 @default.
• W4387643263 creator A5042282225 @default.
• W4387643263 creator A5045689867 @default.
• W4387643263 creator A5048381562 @default.
• W4387643263 creator A5051676242 @default.
• W4387643263 creator A5061342186 @default.
• W4387643263 creator A5074873913 @default.
• W4387643263 creator A5083090268 @default.
• W4387643263 creator A5086664284 @default.
• W4387643263 date "2023-10-01" @default.
• W4387643263 modified "2023-10-15" @default.
• W4387643263 title "Mitochondrial transplantation inhibits cholangiocarcinoma cells growth by balancing oxidative stress tolerance through PTEN/PI3K/AKT signaling pathway" @default.
• W4387643263 cites W1978873476 @default.
• W4387643263 cites W2005815786 @default.
• W4387643263 cites W2070143299 @default.
• W4387643263 cites W2193967519 @default.
• W4387643263 cites W2269620328 @default.
• W4387643263 cites W2292613448 @default.
• W4387643263 cites W2584378351 @default.
• W4387643263 cites W2757407086 @default.
• W4387643263 cites W2760423124 @default.
• W4387643263 cites W2763492611 @default.
• W4387643263 cites W2779534731 @default.
• W4387643263 cites W2790604225 @default.
• W4387643263 cites W2792688102 @default.
• W4387643263 cites W2889646458 @default.
• W4387643263 cites W2896414982 @default.
• W4387643263 cites W2918831470 @default.
• W4387643263 cites W2919632356 @default.
• W4387643263 cites W2952074033 @default.
• W4387643263 cites W2953064112 @default.
• W4387643263 cites W2971370669 @default.
• W4387643263 cites W2982979216 @default.
• W4387643263 cites W2999182948 @default.
• W4387643263 cites W2999959056 @default.
• W4387643263 cites W3012497145 @default.
• W4387643263 cites W3021120925 @default.
• W4387643263 cites W3033978931 @default.
• W4387643263 cites W3039360174 @default.
• W4387643263 cites W3132388122 @default.
• W4387643263 cites W3134630041 @default.
• W4387643263 cites W3208783157 @default.
• W4387643263 cites W3213716385 @default.
• W4387643263 cites W4200307603 @default.
• W4387643263 cites W4210590189 @default.
• W4387643263 cites W4211025847 @default.
• W4387643263 cites W4220817929 @default.
• W4387643263 cites W4225849756 @default.
• W4387643263 cites W4245962407 @default.
• W4387643263 cites W4254119740 @default.
• W4387643263 cites W4361298481 @default.
• W4387643263 cites W4362172418 @default.
• W4387643263 cites W4362505854 @default.
• W4387643263 doi "https://doi.org/10.1016/j.tice.2023.102243" @default.
• W4387643263 hasPublicationYear "2023" @default.
• W4387643263 type Work @default.
• W4387643263 citedByCount "0" @default.
• W4387643263 crossrefType "journal-article" @default.
• W4387643263 hasAuthorship W4387643263A5002188808 @default.
• W4387643263 hasAuthorship W4387643263A5011365744 @default.
• W4387643263 hasAuthorship W4387643263A5042282225 @default.
• W4387643263 hasAuthorship W4387643263A5045689867 @default.
• W4387643263 hasAuthorship W4387643263A5048381562 @default.
• W4387643263 hasAuthorship W4387643263A5051676242 @default.
• W4387643263 hasAuthorship W4387643263A5061342186 @default.
• W4387643263 hasAuthorship W4387643263A5074873913 @default.
• W4387643263 hasAuthorship W4387643263A5083090268 @default.
• W4387643263 hasAuthorship W4387643263A5086664284 @default.
• W4387643263 hasConcept C126322002 @default.
• W4387643263 hasConcept C134018914 @default.
• W4387643263 hasConcept C190283241 @default.
• W4387643263 hasConcept C2776151105 @default.
• W4387643263 hasConcept C2777609662 @default.
• W4387643263 hasConcept C28859421 @default.
• W4387643263 hasConcept C2911091166 @default.
• W4387643263 hasConcept C31573885 @default.
• W4387643263 hasConcept C502942594 @default.
• W4387643263 hasConcept C55493867 @default.
• W4387643263 hasConcept C62112901 @default.
• W4387643263 hasConcept C62478195 @default.
• W4387643263 hasConcept C71924100 @default.
• W4387643263 hasConcept C75217442 @default.
• W4387643263 hasConcept C86554907 @default.
• W4387643263 hasConcept C86803240 @default.
• W4387643263 hasConcept C95444343 @default.
• W4387643263 hasConceptScore W4387643263C126322002 @default.
• W4387643263 hasConceptScore W4387643263C134018914 @default.
• W4387643263 hasConceptScore W4387643263C190283241 @default.
• W4387643263 hasConceptScore W4387643263C2776151105 @default.
• W4387643263 hasConceptScore W4387643263C2777609662 @default.
• W4387643263 hasConceptScore W4387643263C28859421 @default.
• W4387643263 hasConceptScore W4387643263C2911091166 @default.
• W4387643263 hasConceptScore W4387643263C31573885 @default.
• W4387643263 hasConceptScore W4387643263C502942594 @default.
• W4387643263 hasConceptScore W4387643263C55493867 @default.

• next